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Lin Aifu Research Group, Zhejiang University: tumor immune checkpoints and related inhibitors

 Last Update: 2022-11-04
 Source: Internet
 Author: User

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Content introduction

Chinese Summary:

Outline:

Immune checkpoint proteins, including programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), can bind to their respective receptors to promote immune escape by blocking the activation signal of immune cells
.
This immune evasion ability of tumor cells given by immune modification of immune checkpoints makes immune escape one of the important features of
tumors.
Immune checkpoint blocking (ICB) therapy targeting the above molecules inhibits key tumor signaling pathways through antibodies and specific small molecule inhibitors, and cracks the immune tolerance of tumor patients, which has shown excellent clinical benefits
.
Therefore, deciphering the role and regulatory mechanisms of these immune checkpoint molecules will provide key theoretical guidance
for clinical treatment.
In this review, we summarize current information about the function and regulatory mechanisms of these immune checkpoint molecules at multiple levels, including epigenetic regulation, transcriptional regulation, and post-translational modification
.
In addition, we summarize drugs that target various nodes in the regulatory pathway to further elucidate the clinical potential of newly identified immune checkpoint molecules, highlighting their potential implications
for cancer diagnosis and immunotherapy.

Keyword groups:

immune checkpoints; Immune checkpoint inhibitors; PD-L1； CTLA-4； LAG-3； TIGIT； B7 family

Author:

Zerui GAO, Xingyi LING, Chengyu SHI, Ying WANG, Aifu LIN

Citation format of this article:

Zerui GAO, Xingyi LING, Chengyu SHI, Ying WANG, Aifu LIN.
Tumor immune checkpoints and their associated inhibitors[J].
Journal of Zhejiang University Science B, 2022, 23(10): 823-843.

https://doi.
org/10.
1631/jzus.
B2200195

Essential introduction to this article:

Full text download address: https://jzus.
zju.
edu.
cn/oldversion/opentxt.
php?doi=10.
1631/jzus.
B2200195

About this journal

Journal of Zhejiang University (English Edition) Series B: Biomedicine and Biotechnology, referred to as JZUS-B, is a comprehensive English monthly journal
of biology.
JZUS-B has been included in SCI-E since 2008, with a latest impact factor of 5.
552, and has been searched
by well-known domestic and foreign platforms such as MEDLINE/PubMed, PMC, Scopus, BA, BIOSIS Previews, etc.

JZUS-B receives articles in life sciences, medicine, pharmacy, biochemistry, biotechnology and bioengineering, agronomy, ecology, and zoology
.
Article types include Review, Article, Perspective, Viewpoint, Editorial, Correspondence, etc
.

The journal has always implemented a strict international peer review mechanism, with an average review period of 42 days and an average acceptance time of 53 days
.
After acceptance, the article will be immediately online in Press and will generally be officially published
within 2 months.

"Content-oriented, flexible form" is the characteristic of
this journal.
JZUS-B welcomes outstanding scholars at home and abroad to submit the latest scientific research achievements, controversial topics, review papers and organize the publication of hot albums
.

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