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With the rapid development of domestically-made innovative drugs, API equipment is facing new requirements and new demands

 Last Update: 2021-11-25
 Source: Internet
 Author: User

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[ Focus on Chemical Machinery and Equipment Network ] China is a large producer of raw materials, with a normal annual output of about 3 million tons of raw materials.
At the same time, China is also a large exporter of raw materials, with exports accounting for about one-third of the output of raw materials.
However, from the perspective of equipment for the production of APIs, the industrial structure of domestic API equipment is still unreasonable, and the overall level of research and development is low.
Compared with imported API equipment, domestic API equipment is environmentally friendly and energy-saving, safe and stable, and practical.
There are obvious bottlenecks in automation design and other aspects.

Chemical machinery and equipment network hotspots pay attention to chemical machinery and equipment API equipment

It is understood that according to the operation of each unit of API production, the process equipment for the production of raw materials can be divided into: equipment for synthesis reaction, fermentation, extraction, crystallization, metering and material storage, such as reaction tanks , fermentation tanks, and extraction equipment.
Etc.
; equipment used for solid-liquid separation, common filtering equipment such as sterilizing filters and filter presses; equipment used for drying and mixing, such as boiling dryers, etc.
; equipment used for crushing and packaging, such as automatic crushing All-in-one packaging machine; auxiliary equipment for the production of other APIs, such as heat exchangers, feeders, etc.
In different units of APIs, these API production equipments are responsible for their respective important missions.

Reaction tank

The new version of GMP requires that the selection of equipment used for the production of sterile APIs must not only meet the process and output requirements, but also have the function of eliminating and controlling particulates, microbes and bacterial endotoxins.
Under the promotion of the new version of GMP, it can be said that the control requirements for the production of APIs, especially sterile APIs, have been greatly improved.
At the same time, the requirements for API production equipment have also been greatly improved, including cleanliness, airtightness, and material And the control accuracy of the parameters has higher requirements, which is also forcing the transformation and upgrading of the API equipment industry.

The industry pointed out that in addition to the design and selection of API equipment manufacturers, they also need to consider measures to prevent pollution, cross-contamination, and error prevention in order to ensure high-quality production of their products.

In recent years, some domestic API equipment companies have made efforts in the field of environmental protection and energy conservation.
For example, drying equipment manufacturers have continuously strengthened R&D investment to create environmentally friendly and energy-saving API production equipment.
The company has also established a special environmental protection company and supporting engineering experiment center, established the core elements of energy-saving and environmentally-friendly product design, actively developed and produced green equipment, and achieved good economic and social benefits.

There are also many companies incorporating new technologies into the R&D and production of API equipment.
For example, a liquid nitrogen freeze dryer that uses liquid nitrogen as a cold source to cool the system; under the action of the existing vacuum system, the gaseous water can be transported to the freeze dryer pipeline to perform hydrogen peroxide sterilization and disinfection.
Bacteria technology; automatic solid-liquid separation solutions that reduce energy consumption, water consumption, manpower requirements and waste water treatment costs, and improve product recovery rates.
These new technologies, new equipment, and new programs further provide strong technical support for the high-quality production of API companies.

With the accelerated review of new drugs, the development cycle of new drugs is continuously shortening.
At the same time, policies such as centralized procurement have forced the entire pharmaceutical industry to upgrade in the direction of innovation, driving the rapid development of the innovative drug industry.
In the context of the rapid development of domestic innovative drugs, new requirements and new demands for API equipment will also continue to increase.
API equipment companies need to continuously adapt to the new needs and requirements of the market while seizing the opportunity, and innovative equipment and Technology and improved equipment structure can help the innovative drug industry to develop faster and with higher quality.

　　Original title: Under the rapid development of domestic innovative drugs, API equipment is facing new requirements and new demands

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