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You have to take medicine if you are sick, but for the medicine to work, the time of taking the medicine is still the key.
Because this is related to the human body's circadian rhythm (biological clock).
For example, blood pressure has two peaks in the morning and afternoon, so antihypertensive drugs should be scheduled to be taken before the peak is more effective.
As we all know, the biological clock is closely related to life activities.
It controls almost all the biological processes of many animals and plants, including our humans, including our sleep-wakeness, the day and night of animals, the spring and autumn fruits of plants, and our metabolic functions.
And cognitive processes.
Previous studies have shown that this internal clock with a 24-hour cycle has also been confirmed in photosynthetic bacteria.
Photosynthetic bacteria use light to produce chemical energy; but whether non-photosynthetic bacteria are also subject to circadian rhythms, scientists still know little about this.
Recently, in a study published in "Science Advances", an international research team led by the University of Munich in Germany found for the first time that there are also biological clocks in non-photosynthetic bacteria.
They perceive cycles through light or ambient temperature, adapting their molecules to the time of day.
This discovery will bring valuable information to the fields of biomedicine, bio-agriculture and industrial biotechnology.
Mastering the circadian rhythm of bacteria, in the future, the timing of clinical administration will become more accurate.
In this new study, the researchers chose the non-photosynthetic Bacillus subtilis (Bacillus subtilis) as the experimental model, which is a cold-tolerant and well-studied multifunctional microorganism that is distributed in soil and decaying organic matter, including humans.
In the gastrointestinal tract of many animals.
Bacillus subtilis has been widely used in many fields of biomedicine, animal feed production, plant disease resistance, aquaculture and water purification.
Bacillus subtilis (Bacillus subtilis) Although Bacillus subtilis does not perform photosynthesis, it is also very sensitive to light due to the presence of photoreceptors.
Previous observations of Bacillus subtilis have provided clues that their gene activity and biofilm formation process may follow the day-night cycle based on environmental cues (light level or temperature changes).
In order to study in depth, the researchers exposed Bacillus subtilis to 12 hours of continuous light and 12 hours of darkness, and then tested its gene expression activity.
In the light/dark cycle, the expression of the ytvA gene encoding the blue light receptor increases in the dark and decreases in the light, indicating that the circadian rhythm plays a role in this process.
Researchers found that under conditions of constant darkness, the circadian clock of Bacillus subtilis still exists, but the cycle is prolonged.
In the absence of light signals, its biological clock does not strictly follow the 24-hour cycle.
In another experiment, the researchers used temperature cycling to observe.
Similarly, when the temperature is between 25.
5°C and 28.
5°C in a 12-hour cycle, the expression of the ytvA gene also fluctuates, as with light, in a free-running experiment (not synchronized with environmental cues) cycle duration Longer.
The results of these two experiments tell us that non-photosynthetic bacteria also have a biological clock.
The corresponding author of the study, Martha Merrow, a chronobiologist at the University of Munich, said: “Although these findings currently only involve one type of bacteria, this is the first time that researchers have found this phenomenon in non-photosynthetic bacteria.
The understanding has a huge impact, because bacteria account for about 15% of the earth’s total biomass.
"Researchers speculate that the biological clock may be regulated to some extent by the transcription-translation feedback system, and it may also be related to the metabolic cycle.
It is unclear whether there is some form of core clock that can control the circadian rhythm of Bacillus subtilis, just like in the human body, but the researchers point out that this is a possibility.
The researchers said that studying the core clock of Bacillus subtilis or whether they have multiple time oscillators will provide us with more valuable information.
In any case, the impact of the 24-hour biological clock on bacteria may be of great significance.
This is not only a scientific understanding of bacterial biology, but also includes potential applications in the fields of biomedicine, bio-agriculture, and industrial biotechnology.
The co-corresponding author of the study, Dr.
Ákos Kovács of the Bacterial Interaction and Evolution Group of the Bioengineering Department of the Technical University of Denmark, said: “Bacillus subtilis is used in daily chemical production and even crop protection in addition to probiotics for humans and animals.
Various fields.
Therefore, designing a biological clock in this kind of bacteria will enable breakthroughs in different fields of biotechnology.
"The link to the paper: https://advances.
sciencemag.
org/content/7/2/eabe2086 2019 hot article TOP101.
Reversal The big cow with type 2 diabetes has published another article: Type 2 diabetes is a simple disease, lose weight or reverse the condition! 2.
Just now, Science released the top ten scientific breakthroughs in 2019! 3.
Science is heavy! Broccoli "awakens" anti-tumor genes 4.
Readers' tears! "The Lancet" published a Chinese medical doctor's "Family Letter" in Chinese: A Letter to Father 5.
"Science" is heavy! Your "honey", my "arsenic.
.
.
" 6.
Drink alcohol, especially those who are still blushing, or face a higher risk of dementia 7.
Nature is heavy! The first completely synthetic creature that completely changed the DNA code was born 8.
This is not a big hazelnut! Science has published a new type of oral insulin, or it will replace traditional injections 9.
Science's anti-balding tips: start with no hair loss.
.
.
10.
Can changing the sperm speed affect the sex of the offspring?
Because this is related to the human body's circadian rhythm (biological clock).
For example, blood pressure has two peaks in the morning and afternoon, so antihypertensive drugs should be scheduled to be taken before the peak is more effective.
As we all know, the biological clock is closely related to life activities.
It controls almost all the biological processes of many animals and plants, including our humans, including our sleep-wakeness, the day and night of animals, the spring and autumn fruits of plants, and our metabolic functions.
And cognitive processes.
Previous studies have shown that this internal clock with a 24-hour cycle has also been confirmed in photosynthetic bacteria.
Photosynthetic bacteria use light to produce chemical energy; but whether non-photosynthetic bacteria are also subject to circadian rhythms, scientists still know little about this.
Recently, in a study published in "Science Advances", an international research team led by the University of Munich in Germany found for the first time that there are also biological clocks in non-photosynthetic bacteria.
They perceive cycles through light or ambient temperature, adapting their molecules to the time of day.
This discovery will bring valuable information to the fields of biomedicine, bio-agriculture and industrial biotechnology.
Mastering the circadian rhythm of bacteria, in the future, the timing of clinical administration will become more accurate.
In this new study, the researchers chose the non-photosynthetic Bacillus subtilis (Bacillus subtilis) as the experimental model, which is a cold-tolerant and well-studied multifunctional microorganism that is distributed in soil and decaying organic matter, including humans.
In the gastrointestinal tract of many animals.
Bacillus subtilis has been widely used in many fields of biomedicine, animal feed production, plant disease resistance, aquaculture and water purification.
Bacillus subtilis (Bacillus subtilis) Although Bacillus subtilis does not perform photosynthesis, it is also very sensitive to light due to the presence of photoreceptors.
Previous observations of Bacillus subtilis have provided clues that their gene activity and biofilm formation process may follow the day-night cycle based on environmental cues (light level or temperature changes).
In order to study in depth, the researchers exposed Bacillus subtilis to 12 hours of continuous light and 12 hours of darkness, and then tested its gene expression activity.
In the light/dark cycle, the expression of the ytvA gene encoding the blue light receptor increases in the dark and decreases in the light, indicating that the circadian rhythm plays a role in this process.
Researchers found that under conditions of constant darkness, the circadian clock of Bacillus subtilis still exists, but the cycle is prolonged.
In the absence of light signals, its biological clock does not strictly follow the 24-hour cycle.
In another experiment, the researchers used temperature cycling to observe.
Similarly, when the temperature is between 25.
5°C and 28.
5°C in a 12-hour cycle, the expression of the ytvA gene also fluctuates, as with light, in a free-running experiment (not synchronized with environmental cues) cycle duration Longer.
The results of these two experiments tell us that non-photosynthetic bacteria also have a biological clock.
The corresponding author of the study, Martha Merrow, a chronobiologist at the University of Munich, said: “Although these findings currently only involve one type of bacteria, this is the first time that researchers have found this phenomenon in non-photosynthetic bacteria.
The understanding has a huge impact, because bacteria account for about 15% of the earth’s total biomass.
"Researchers speculate that the biological clock may be regulated to some extent by the transcription-translation feedback system, and it may also be related to the metabolic cycle.
It is unclear whether there is some form of core clock that can control the circadian rhythm of Bacillus subtilis, just like in the human body, but the researchers point out that this is a possibility.
The researchers said that studying the core clock of Bacillus subtilis or whether they have multiple time oscillators will provide us with more valuable information.
In any case, the impact of the 24-hour biological clock on bacteria may be of great significance.
This is not only a scientific understanding of bacterial biology, but also includes potential applications in the fields of biomedicine, bio-agriculture, and industrial biotechnology.
The co-corresponding author of the study, Dr.
Ákos Kovács of the Bacterial Interaction and Evolution Group of the Bioengineering Department of the Technical University of Denmark, said: “Bacillus subtilis is used in daily chemical production and even crop protection in addition to probiotics for humans and animals.
Various fields.
Therefore, designing a biological clock in this kind of bacteria will enable breakthroughs in different fields of biotechnology.
"The link to the paper: https://advances.
sciencemag.
org/content/7/2/eabe2086 2019 hot article TOP101.
Reversal The big cow with type 2 diabetes has published another article: Type 2 diabetes is a simple disease, lose weight or reverse the condition! 2.
Just now, Science released the top ten scientific breakthroughs in 2019! 3.
Science is heavy! Broccoli "awakens" anti-tumor genes 4.
Readers' tears! "The Lancet" published a Chinese medical doctor's "Family Letter" in Chinese: A Letter to Father 5.
"Science" is heavy! Your "honey", my "arsenic.
.
.
" 6.
Drink alcohol, especially those who are still blushing, or face a higher risk of dementia 7.
Nature is heavy! The first completely synthetic creature that completely changed the DNA code was born 8.
This is not a big hazelnut! Science has published a new type of oral insulin, or it will replace traditional injections 9.
Science's anti-balding tips: start with no hair loss.
.
.
10.
Can changing the sperm speed affect the sex of the offspring?
