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Maintaining a high and constant body temperature in a warm-blooded animal is essential for its survival, and the maintenance of body temperature has a higher energy cost, and body temperature regulation is a classic physiological problem.
Thyroid hormones are secreted by thyroid cells, including thyroxine (T4) and triiodothyronine (T3).
T4 is deiodized by iodothyronine deiodinase II (DIO2) to produce T3 and act on it.
Hormones can improve energy metabolism, promote growth and development and increase the excitability of the nervous system.
Disorders of thyroid hormone metabolism can develop into hyperthyroidism (hyperthyroidism) or hypothyroidism (weakened thyroid function).
Genetics, drugs, and long-term stress are the main factors that form hyperthyroidism.
The incidence is high and it is difficult to treat.
Regarding the mechanism of thyroid hormone regulating metabolic heat production, studies have suggested that it mainly acts on organs to regulate the metabolic processes of cells through central regulatory pathways or peripherals.
Earlier studies have found that gut microbes can regulate the energy metabolism of host animals.
Is thyroid dysfunction related to the imbalance of intestinal flora, which leads to changes in energy metabolism and thermogenesis? The explanation of this problem can reveal the thermoregulation mechanism of warm-blooded animals and provide a scientific basis for understanding the causes and treatments of thyroid diseases.
Recently, Wang Dehua’s research team from the Institute of Zoology, Chinese Academy of Sciences published a research paper on Microbial Biotechnology, Caecal microbial transplantation attenuates hyperthyroid-induced thermogenesis in Mongolian gerbils, and found that the increased metabolism caused by hyperthyroidism (hyperthyroidism) is caused by intestinal flora disorders.
, Clarified the regulation function of the "thyroid-intestinal flora" axis on the heat production and body temperature of warm-blooded animals.Previously, the research team discovered the energy saving mechanism of intestinal flora-mediated heat generation by clustering behavior (Microbiome, 2018).
Fecal eating behavior regulates host energy balance, neurological function and cognitive behavior by maintaining microbial homeostasis (The ISME Journal , 2020), and further discovered that the intestinal flora confers metabolic plasticity to warm animals against periodic temperature fluctuations (mSystems, 2020), and the mechanism by which the "sympathetic nerve-gut flora" axis regulates cold-adaptive heat production (The ISME Journal) , 2019) and other results.
This is another new discovery of the research team in the field of the interaction between wild animals and their gut microbes in the regulation of energy metabolism and thermogenesis.
The researchers used Meriones unguiculatus T4 treatment for 4 weeks to induce hyperthyroidism model, and used methimazole drug treatment to block the synthesis of thyroid hormone to induce hypothyroidism model.
Studies have found that hyperthyroidism animals exhibit higher metabolic rate and body temperature, and hypothyroidism animals have a significantly lower metabolic rate; regardless of hyperthyroidism or hypothyroidism animals, the structure of the intestinal flora is disordered, and the intestines of hyperthyroidism animals are Helicobacter and Riken bacteria.
The relative proportion of Rikenella is higher, while the relative proportion of beneficial bacteria such as Butyricimonas and Parabacteroides is lower.
Correlation analysis shows that these bacterial genera are closely related to thyroxine metabolism; intestinal bacteria of hyperthyroidism animals The short-chain fatty acid content and total bile acid content of the metabolites of the group were significantly reduced.
Transplanting normal animal-derived intestinal flora in hyperthyroid animals can promote the expression of iodothyronine deiodinase II (DIO2) in the liver, increase the metabolic turnover rate of T3 and T4, and promote the metabolic rate and body temperature of hyperthyroid animals.
restore.
This study clarified the regulation effect of the "thyroid-gut microbiota" axis on the heat production and body temperature of warm-blooded animals, revealed the physiological significance of the interaction between the gut microbiota and the host endocrine system in regulating body temperature, and provided treatment for hyperthyroidism.
Possible effective interventions. Saeid Khakisahneh, a PhD student in the Animal Physiology and Ecology Research Group of the State Key Laboratory of Comprehensive Management of Agricultural Pests and Rodents, and associate researcher Zhang Xueying are the co-first authors of the paper.
Researcher Wang Dehua and associate researcher Zhang Xueying are the co-corresponding authors of the paper.
The research work was funded by the National Natural Science Foundation of China.
The effect of the "thyroid-intestinal flora" axis on the metabolic thermogenesis and thermoregulation of the unguiculatus gerbils Link to the paper: https://doi.
org/10.
1111/1751-7915.
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.
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Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
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.
Thyroid hormones are secreted by thyroid cells, including thyroxine (T4) and triiodothyronine (T3).
T4 is deiodized by iodothyronine deiodinase II (DIO2) to produce T3 and act on it.
Hormones can improve energy metabolism, promote growth and development and increase the excitability of the nervous system.
Disorders of thyroid hormone metabolism can develop into hyperthyroidism (hyperthyroidism) or hypothyroidism (weakened thyroid function).
Genetics, drugs, and long-term stress are the main factors that form hyperthyroidism.
The incidence is high and it is difficult to treat.
Regarding the mechanism of thyroid hormone regulating metabolic heat production, studies have suggested that it mainly acts on organs to regulate the metabolic processes of cells through central regulatory pathways or peripherals.
Earlier studies have found that gut microbes can regulate the energy metabolism of host animals.
Is thyroid dysfunction related to the imbalance of intestinal flora, which leads to changes in energy metabolism and thermogenesis? The explanation of this problem can reveal the thermoregulation mechanism of warm-blooded animals and provide a scientific basis for understanding the causes and treatments of thyroid diseases.
Recently, Wang Dehua’s research team from the Institute of Zoology, Chinese Academy of Sciences published a research paper on Microbial Biotechnology, Caecal microbial transplantation attenuates hyperthyroid-induced thermogenesis in Mongolian gerbils, and found that the increased metabolism caused by hyperthyroidism (hyperthyroidism) is caused by intestinal flora disorders.
, Clarified the regulation function of the "thyroid-intestinal flora" axis on the heat production and body temperature of warm-blooded animals.Previously, the research team discovered the energy saving mechanism of intestinal flora-mediated heat generation by clustering behavior (Microbiome, 2018).
Fecal eating behavior regulates host energy balance, neurological function and cognitive behavior by maintaining microbial homeostasis (The ISME Journal , 2020), and further discovered that the intestinal flora confers metabolic plasticity to warm animals against periodic temperature fluctuations (mSystems, 2020), and the mechanism by which the "sympathetic nerve-gut flora" axis regulates cold-adaptive heat production (The ISME Journal) , 2019) and other results.
This is another new discovery of the research team in the field of the interaction between wild animals and their gut microbes in the regulation of energy metabolism and thermogenesis.
The researchers used Meriones unguiculatus T4 treatment for 4 weeks to induce hyperthyroidism model, and used methimazole drug treatment to block the synthesis of thyroid hormone to induce hypothyroidism model.
Studies have found that hyperthyroidism animals exhibit higher metabolic rate and body temperature, and hypothyroidism animals have a significantly lower metabolic rate; regardless of hyperthyroidism or hypothyroidism animals, the structure of the intestinal flora is disordered, and the intestines of hyperthyroidism animals are Helicobacter and Riken bacteria.
The relative proportion of Rikenella is higher, while the relative proportion of beneficial bacteria such as Butyricimonas and Parabacteroides is lower.
Correlation analysis shows that these bacterial genera are closely related to thyroxine metabolism; intestinal bacteria of hyperthyroidism animals The short-chain fatty acid content and total bile acid content of the metabolites of the group were significantly reduced.
Transplanting normal animal-derived intestinal flora in hyperthyroid animals can promote the expression of iodothyronine deiodinase II (DIO2) in the liver, increase the metabolic turnover rate of T3 and T4, and promote the metabolic rate and body temperature of hyperthyroid animals.
restore.
This study clarified the regulation effect of the "thyroid-gut microbiota" axis on the heat production and body temperature of warm-blooded animals, revealed the physiological significance of the interaction between the gut microbiota and the host endocrine system in regulating body temperature, and provided treatment for hyperthyroidism.
Possible effective interventions. Saeid Khakisahneh, a PhD student in the Animal Physiology and Ecology Research Group of the State Key Laboratory of Comprehensive Management of Agricultural Pests and Rodents, and associate researcher Zhang Xueying are the co-first authors of the paper.
Researcher Wang Dehua and associate researcher Zhang Xueying are the co-corresponding authors of the paper.
The research work was funded by the National Natural Science Foundation of China.
The effect of the "thyroid-intestinal flora" axis on the metabolic thermogenesis and thermoregulation of the unguiculatus gerbils Link to the paper: https://doi.
org/10.
1111/1751-7915.
13793 2020 hot articles selection 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
