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The role of the microbiome in human health and disease has received increasing attention, and has become a hotspot and key area of life sciences in the past decade.
Research on the basic composition and function of the human microbiome, such as the intestinal flora, has accumulated a lot of data, but there are still many problems that need to be solved urgently in the environment and host factors that affect the microbiome.
The human genome interacts closely with the genes and microbiome related to metabolism and immunity, which may affect the diversity of microorganisms; however, as the microbiome is a complex ecosystem, there are a large number of random factors interfered, so the human body influences the host microbial composition Genome-wide association studies (GWAS) must be carried out in a large population of genes, and a series of innovations in analysis methods must be carried out at the same time.
Recently, Nature Genetics published online the latest research results of the international large-scale research project "MiBioGen" "Large-scale association analyses identify host factors influencing human gut microbiome composition" (2021, 53:156-165), Chinese Academy of Sciences Microbiome King Jun Jun is the co-first author of the article and the only participant from China.
The study included 24 cohorts from multiple countries and races in Europe, America, the Middle East, and East Asia, and the genome and gut microbiota data of more than 18,000 people.
It is by far the largest GWAS work on gut microbiota.
This paper reveals the heterogeneity of intestinal flora among different populations, and at the same time identifies bacterial groups with higher heritability, as well as multiple gene loci that affect the composition of the flora, and through gene set enrichment analysis, the whole Phenotypic association studies and Mendelian randomization methods have explored the potential impact of genetic-microbe associations on host health-related characteristics.
"MiBioGen" is a large-scale international research project initiated by Wang Jun and a number of scientists in Belgium and the Netherlands to study the impact of human genes on the gut microbiota from a genome-wide level.
The project has established a series of new research methods.
This result is the first batch of research results to be officially published.
Figure 1: The title of the natural genetics article and the basic information of the population collected in the project.
In addition, researcher Wang Jun, in cooperation with West Lake University and Sun Yat-sen University, recently published "The interplay between host genetics and the gut microbiome reveals common and distinct" on Microbiome "microbiome features for complex human diseases" (2020, 8:145), they conducted GWAS analysis on the microbiome of 1475 Chinese people to explore the influence of heredity on the intestinal flora; through a two-way Mendelian randomization analysis, they studied The causal relationship between human intestinal flora and complex diseases, and clustering of different diseases according to the similarities and characteristics of the flora characteristics, and discovering the common flora characteristics between different diseases, such as Parkinson's disease and colorectal cancer There may be similar flora characteristics between systemic lupus erythematosus and chronic myelogenous leukemia.
This is also the first systematic study of flora-related GWAS in the Chinese population, which is of great significance for understanding the interaction of genes and flora in the Chinese population and the occurrence of diseases.
Figure 2: GWAS analysis in the Chinese population and follow-up research on the association with diseases.
Wang Jun’s research group has long been concerned about the interaction between human genes and the microbiome in health and disease, and has conducted a series of more in-depth studies using GWAS tools .In 2016, he published a cover article in Nature Genetics and completed the first flora GWAS (Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
2016, 48:1396–1406).
Invited to be an important domestic journal Protein Cell published a review article "Of genes and microbes: solving the intricacies in host genomes" (2018, 9(5):446-461), systematically introducing the research methods and existing work of gene-microbes interaction; in Chinese science: “Strengthening the functional research on the interaction between host genes and microbiota” (2020, 63: 929–932) was published in Life Science (Science China: Life Science), calling for more research in the Chinese population and domestic and foreign Cooperation to jointly analyze the genetic basis of the structure and function of the human microbiome.
The project of Wang Jun's research group was funded by the Chinese Academy of Sciences' strategic pilot project "Pathogen Host Adaptability and Immune Intervention", a key research and development project of the Ministry of Science and Technology, a major research program cultivation project of the National Natural Science Foundation of China, and a general project.
Picture 3: Researcher Wang Jun was invited to give a review for the Protein Cell special issue.
The main picture was selected as the back cover picture of the current issue.
The 2020 Hot Article Featured 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
Research on the basic composition and function of the human microbiome, such as the intestinal flora, has accumulated a lot of data, but there are still many problems that need to be solved urgently in the environment and host factors that affect the microbiome.
The human genome interacts closely with the genes and microbiome related to metabolism and immunity, which may affect the diversity of microorganisms; however, as the microbiome is a complex ecosystem, there are a large number of random factors interfered, so the human body influences the host microbial composition Genome-wide association studies (GWAS) must be carried out in a large population of genes, and a series of innovations in analysis methods must be carried out at the same time.
Recently, Nature Genetics published online the latest research results of the international large-scale research project "MiBioGen" "Large-scale association analyses identify host factors influencing human gut microbiome composition" (2021, 53:156-165), Chinese Academy of Sciences Microbiome King Jun Jun is the co-first author of the article and the only participant from China.
The study included 24 cohorts from multiple countries and races in Europe, America, the Middle East, and East Asia, and the genome and gut microbiota data of more than 18,000 people.
It is by far the largest GWAS work on gut microbiota.
This paper reveals the heterogeneity of intestinal flora among different populations, and at the same time identifies bacterial groups with higher heritability, as well as multiple gene loci that affect the composition of the flora, and through gene set enrichment analysis, the whole Phenotypic association studies and Mendelian randomization methods have explored the potential impact of genetic-microbe associations on host health-related characteristics.
"MiBioGen" is a large-scale international research project initiated by Wang Jun and a number of scientists in Belgium and the Netherlands to study the impact of human genes on the gut microbiota from a genome-wide level.
The project has established a series of new research methods.
This result is the first batch of research results to be officially published.
Figure 1: The title of the natural genetics article and the basic information of the population collected in the project.
In addition, researcher Wang Jun, in cooperation with West Lake University and Sun Yat-sen University, recently published "The interplay between host genetics and the gut microbiome reveals common and distinct" on Microbiome "microbiome features for complex human diseases" (2020, 8:145), they conducted GWAS analysis on the microbiome of 1475 Chinese people to explore the influence of heredity on the intestinal flora; through a two-way Mendelian randomization analysis, they studied The causal relationship between human intestinal flora and complex diseases, and clustering of different diseases according to the similarities and characteristics of the flora characteristics, and discovering the common flora characteristics between different diseases, such as Parkinson's disease and colorectal cancer There may be similar flora characteristics between systemic lupus erythematosus and chronic myelogenous leukemia.
This is also the first systematic study of flora-related GWAS in the Chinese population, which is of great significance for understanding the interaction of genes and flora in the Chinese population and the occurrence of diseases.
Figure 2: GWAS analysis in the Chinese population and follow-up research on the association with diseases.
Wang Jun’s research group has long been concerned about the interaction between human genes and the microbiome in health and disease, and has conducted a series of more in-depth studies using GWAS tools .In 2016, he published a cover article in Nature Genetics and completed the first flora GWAS (Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
2016, 48:1396–1406).
Invited to be an important domestic journal Protein Cell published a review article "Of genes and microbes: solving the intricacies in host genomes" (2018, 9(5):446-461), systematically introducing the research methods and existing work of gene-microbes interaction; in Chinese science: “Strengthening the functional research on the interaction between host genes and microbiota” (2020, 63: 929–932) was published in Life Science (Science China: Life Science), calling for more research in the Chinese population and domestic and foreign Cooperation to jointly analyze the genetic basis of the structure and function of the human microbiome.
The project of Wang Jun's research group was funded by the Chinese Academy of Sciences' strategic pilot project "Pathogen Host Adaptability and Immune Intervention", a key research and development project of the Ministry of Science and Technology, a major research program cultivation project of the National Natural Science Foundation of China, and a general project.
Picture 3: Researcher Wang Jun was invited to give a review for the Protein Cell special issue.
The main picture was selected as the back cover picture of the current issue.
The 2020 Hot Article Featured 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
