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There is a need for low-cost, rapid, and accurate detection of harmful organisms. Some species of the marine dinoflagellate
Alexandrium
produce paralytic shellfish toxins that can accumulate in shellfish tissue and can cause paralysis and death if ingested by humans. We have developed a method for RNA detection of
Alexandrium
using a portable surface plasmon resonance biosensing instrument and peptide nucleic acid probes. Because our method is user-friendly, cost-effective, and yields quick results, it will greatly improve the abilities of monitoring programs to detect harmful species and take appropriate measures to prevent detrimental human health effects.