The relationship between intestinal flora and Parkinson's disease

On April 11, 1997, the World Health Organization (WHO) designated April 11 each year as "World Parkinson's Disease Day". This day is the birthday of the British physician Dr. James Parkinson, the discoverer of Parkinson's disease. Many countries have chosen to hold Parkinson's disease-themed activities on April 11th, including knowledge lectures and expert consultations. Aging is increasing the incidence of Parkinson's and the patients are getting younger!Parkinson’s disease (PD) is a neurodegenerative disease common in middle-aged and elderly people. It usually starts at the age of 50-65. It mainly manifests as slow movements, involuntary tremor of the hands, head or mouth when stationary, muscle stiffness, and body stiffness. Loss of flexibility, stiffness and postural balance disorders. Symptoms usually appear from one limb and gradually spread to the opposite side or the whole body. Patients with advanced disease are lying in bed stiffly and cannot take care of themselves. With the advent of the world’s aging society, the incidence of Parkinson’s disease gradually increases with age. The prevalence rate of Parkinson's disease is 1. 7% for the elderly over 65 years old, and the prevalence rate is 3-5% for those over 70 years old. It is the third killer of middle-aged and elderly people after tumors and cardiovascular and cerebrovascular diseases, which seriously affects the work ability and quality of life of patients. . At present, Parkinson's patients are becoming younger, and juvenile Parkinson's disease accounts for 10% of the total number. 　　Parkinson's first originated in the gastrointestinal tract. Abnormal flora can cause intestinal leakage and excessive activation of innate immunity, damage the enteric nervous system (enteric nerve and glial activation), and cause misfolded synuclein (α-syn) to appear , And can be transmitted to the brain through the vagus nerve, causing neurodegeneration. 　　The gut microbes of Parkinson's patients have changed significantly, and these abnormal microbes are significantly related to Parkinson's symptoms. Follow-up studies also found that gut bacteria can predict disease progression. For example, patients with too few Bifidobacteria are more likely to have hallucinations and delusions, and Bacteroides fragilis are more likely to be less active after they are too few. Researchers have begun to consider the use of gut microbes as an early screening indicator for Parkinson's disease. 　　Scientific research shows that supplementing with probiotics can improve Parkinson's symptoms. It can significantly change the digestive function of the stomach and intestines, correct the disorder of the flora, improve metabolism, and restore the content of dopamine (DA) and serotonin (5-HT) in the striatum of the brain. Intestinal microbes may alleviate Parkinson's symptoms by adjusting neuroimmunity and regulating the activities of microglia and astrocytes.      Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com. The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself.      Copyright Notice    1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author. 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and clearly indicate the source and author. Media or individuals who do not want to be reprinted can contact us for infringement information that can provide sufficient evidence , Bio149 will be deleted within 12 hours after confirmation. 3. Users are welcome to post original articles to 86371366@qq. com, and publish them to the homepage after review. The copyright and liability belong to the sender.

　　On April 11, 1997, the World Health Organization (WHO) designated April 11 each year as "World Parkinson's Disease Day".
This day is the birthday of the British physician Dr.
James Parkinson, the discoverer of Parkinson's disease.
Many countries have chosen to hold Parkinson's disease-themed activities on April 11th, including knowledge lectures and expert consultations.
　　Aging is increasing the incidence of Parkinson's and the patients are getting younger! 　　Parkinson’s disease (PD) is a neurodegenerative disease common in middle-aged and elderly people.
It usually starts at the age of 50-65.
It mainly manifests as slow movements, involuntary tremor of the hands, head or mouth when stationary, muscle stiffness, and body stiffness.
Loss of flexibility, stiffness and postural balance disorders.
Symptoms usually appear from one limb and gradually spread to the opposite side or the whole body.
Patients with advanced disease are lying in bed stiffly and cannot take care of themselves.
　　With the advent of the world’s aging society, the incidence of Parkinson’s disease gradually increases with age.
　　The prevalence rate of Parkinson's disease is 1.
7% for the elderly over 65 years old, and the prevalence rate is 3-5% for those over 70 years old.
It is the third killer of middle-aged and elderly people after tumors and cardiovascular and cerebrovascular diseases, which seriously affects the work ability and quality of life of patients.
.
At present, Parkinson's patients are becoming younger, and juvenile Parkinson's disease accounts for 10% of the total number.
　　Parkinson's first originated in the gastrointestinal tract.
Abnormal flora can cause intestinal leakage and excessive activation of innate immunity, damage the enteric nervous system (enteric nerve and glial activation), and cause misfolded synuclein (α-syn) to appear , And can be transmitted to the brain through the vagus nerve, causing neurodegeneration.
　　The gut microbes of Parkinson's patients have changed significantly, and these abnormal microbes are significantly related to Parkinson's symptoms.
Follow-up studies also found that gut bacteria can predict disease progression.
For example, patients with too few Bifidobacteria are more likely to have hallucinations and delusions, and Bacteroides fragilis are more likely to be less active after they are too few.
Researchers have begun to consider the use of gut microbes as an early screening indicator for Parkinson's disease. 　　Scientific research shows that supplementing with probiotics can improve Parkinson's symptoms.
It can significantly change the digestive function of the stomach and intestines, correct the disorder of the flora, improve metabolism, and restore the content of dopamine (DA) and serotonin (5-HT) in the striatum of the brain.
Intestinal microbes may alleviate Parkinson's symptoms by adjusting neuroimmunity and regulating the activities of microglia and astrocytes.

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　　On April 11, 1997, the World Health Organization (WHO) designated April 11 each year as "World Parkinson's Disease Day".
This day is the birthday of the British physician Dr.
James Parkinson, the discoverer of Parkinson's disease.
Many countries have chosen to hold Parkinson's disease-themed activities on April 11th, including knowledge lectures and expert consultations.
　　Aging is increasing the incidence of Parkinson's and the patients are getting younger! 　　Parkinson’s disease (PD) is a neurodegenerative disease common in middle-aged and elderly people.
It usually starts at the age of 50-65.
It mainly manifests as slow movements, involuntary tremor of the hands, head or mouth when stationary, muscle stiffness, and body stiffness.
Loss of flexibility, stiffness and postural balance disorders.
Symptoms usually appear from one limb and gradually spread to the opposite side or the whole body.
Patients with advanced disease are lying in bed stiffly and cannot take care of themselves.
　　With the advent of the world’s aging society, the incidence of Parkinson’s disease gradually increases with age.
　　The prevalence rate of Parkinson's disease is 1.
7% for the elderly over 65 years old, and the prevalence rate is 3-5% for those over 70 years old.
It is the third killer of middle-aged and elderly people after tumors and cardiovascular and cerebrovascular diseases, which seriously affects the work ability and quality of life of patients.
.
At present, Parkinson's patients are becoming younger, and juvenile Parkinson's disease accounts for 10% of the total number.
　　Parkinson's first originated in the gastrointestinal tract.
Abnormal flora can cause intestinal leakage and excessive activation of innate immunity, damage the enteric nervous system (enteric nerve and glial activation), and cause misfolded synuclein (α-syn) to appear , And can be transmitted to the brain through the vagus nerve, causing neurodegeneration.
　　The gut microbes of Parkinson's patients have changed significantly, and these abnormal microbes are significantly related to Parkinson's symptoms.
Follow-up studies also found that gut bacteria can predict disease progression.
For example, patients with too few Bifidobacteria are more likely to have hallucinations and delusions, and Bacteroides fragilis are more likely to be less active after they are too few.
Researchers have begun to consider the use of gut microbes as an early screening indicator for Parkinson's disease. 　　Scientific research shows that supplementing with probiotics can improve Parkinson's symptoms.
It can significantly change the digestive function of the stomach and intestines, correct the disorder of the flora, improve metabolism, and restore the content of dopamine (DA) and serotonin (5-HT) in the striatum of the brain.
Intestinal microbes may alleviate Parkinson's symptoms by adjusting neuroimmunity and regulating the activities of microglia and astrocytes.

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