The Relationship between Helicobacter Pylori Infection and Remnant Gastritis in 152 Cases

NetworkThe relationship between Helicobacter pyridobacteria infection and residual gastritis 152 cases In order to explore the relationship between Helicobacter pyridobacteria (Hp) infection and residual gastritis, we conducted relevant studies on 152 inpatients and outpatients with upper digestive tract symptoms after gastric partial excision from 1988-08 to 1993-08.1 objects and methods 1.1 objects 152 patients with upper digestive tract symptoms in our hospital and outpatient hospitals. Among them, there were 135 cases of partial gastric excision due to peptic ulcers and 17 cases of gastric site removal due to stomach cancer. Of the 152 cases, 131 were men and 21 were women, with a ratio of 6.24:1 between men and women. The age range is 16 to 78 years old. The majority (105 cases) were aged 45 to 69, accounting for 69.8%. The course of illness is 1 month to 35a, with an average of 8.2a.1.2 methodbe compared by group observation of the patient's pre-gastric preoperative morbidity and surgical procedure. The patients were examined by fiber gastroscopy and had biopsies
tissues
3 to 5 pieces in the matching mouth and residual stomach for pathological examination and HP testing. Biopsy tissue for rapid urea enzyme testing and tissue
for
for Warthin-Starry silver staining.
reagents
"Hp Rapid Detection Diagnostic Box" produced by Lanzhou Military Medical School and W-S dyeing fluid provided by Fujian Sanqiang Biochemical Co., Ltd. The results of both examinations were negative, with HP negative. After examination, the patient from the 2nd day to take Gyeantamycin 80,000 U, 200mg, 3 times a day, Lizhu Dele 110mg, 4 times a day; After 4 weeks of treatment, the above examinations are repeated by a person within 3d. 2 Results100% of the 152 cases of residual gastric patients developed residual gastritis (of which 44 cases were accompanied by mouth ulcers, 2 cases of residual stomach cancer and 2 cases of relapsed stomach cancer). The hp positive detection rate was 48.0% (73/152). Among them, peptic ulcer surgery the latter HP positive detection rate of 48.2% (65/135), gastric cancer surgery hp positive detection rate of 47.1% (8/17), the difference between the two No significantness (P>0.05); In the post-residual gastritis group, the hp positive detection rate was 37.0% (20/54), with significant differences (P<0.05); Bile reflowers accounted for 24.7 per cent (20/81), while bile reflowers were 57.4 per cent (31/54) in the postoperative group. There was a very significant difference (P<0.01); in the residual gastritis group without bile refracing, the hp-positive detection rate was 58.33% (49/84), while in the residual gastritis group with bile refraceration, the hp-positive detection rate was 31.37% (16/51). The difference between the two was very significant (P<0.01); 23 patients with HP-positive residual gastritis were reviewed after the above treatment, the inflammation of the mucous membranes of the residual stomach improved, and the remaining changes were detailed in Table 1.Table 1 Changes in various types of residual gastritis after treatment
Diagnostic hp trans mucous membrane inflammation
improved (%) matching ulcers healing (%) bile reflowdisappearing (%) residual gastritis and matching osteoarthritis 71.4 100.0 - - (5/7) ) (7/7) - 85.7 Remnants of gastritis - Matching mouthitis 71.4 100.0 80.0 (6/7) - Bile reflow (5/7) (7/7) - Residual gastritis - Matching mouth ulcers 80. 0 100． 0（4/5） （5/5） （4/5） 100． 0 Residual gastritis and matching mouth ulcers 75. 0 100． 0 75． 0-plus bile reflow (3/4) (4/4) (3/4) (4/4) 3 DiscussionA series of histological changes often occur in the residual stomach after a partial gastric excision. After partial gastric excision, 60% to 100% of patients developed residual gastritis, and the rate of HP-positive detection in the residual stomach was reported at 25% to 71%. In this paper, the hp positive detection rate was 48.0%, which was basically the same as that of Yang Haitao and other reported normal gastric mucous membrane HP detection rate of 3.7%. At the same time, we observed that 23 patients with HP-positive residual gastritis, after treatment to review the inflammation of the mucous membranes of the residual stomach have improved, 17 cases of HP negative, symptoms disappeared, the results show that the occurrence of residual gastritis and HP infection has a closer correlation. There was no significant difference in hp-positive rates between Bi's I. and II. In this paper, the HP-positive detection rate (55.6%) was higher than that of Bi's I.S.-type group (37.0%) (P<0.05).reported that bile reflow after Bi's II.-type surgery was more severe than after Bi's I.-type surgery. In this paper, bile reflowers accounted for 57.4% of the bile reflowers in the Bi's I. group, compared with 24.7% in Bi's I. group, and there was a significant difference between the two (P<0.01). Some scholars believe that Hp generally does not appear in reflow gastritis. In this paper, the residual gastritis group with bile refracy, hp positive detection rate (58.3%), higher than the residual gastritis group (31.4%) (P<0.01). This may be related to the change of the gastric mucous membrane barrier caused by bile reflow, forming a micro-environment that is not suitable for HP to survive, or a certain concentration of bile can kill HP, so that the residual gastritis HP positive detection rate of bile reflow is low, but does not mean that bile reflow reflow gastritis does not appear HP infection. Hp infection does increase the risk of stomach cancer, which may be one of the factors that can occur in stomach cancer. In this paper, the postoperative gastritis of gastric cancer, hp positive detection rate of 47.1% (8/17), which is preoperative or postoperative infection, worthy of further study.results of this paper show that the occurrence of residual gastritis is closely related to HP infection, in addition, it is also related to surgical procedure and bile reflow. Hp can significantly aggravate the damage to the gastric mucous membrane barrier, drug treatment can effectively remove HP, its mucous membrane barrier will be significantly improved, Hp is not removed, then the mucous membrane barrier recovery is poor. Further, residual gastritis is recognized as one of the pre-cancer states of stomach cancer. We believe that the treatment of residual gastritis, in addition to the application of gastric mucous membrane protection agents and anti-reflow drugs, should be combined with antimicrobials, in order to effectively remove HP, promote gastric mucous membrane repair, improve efficacy, and the prevention of residual gastric cancer may have important significance.Zhong Weirun Huang YuanxuanDepartment of Digestive Internal Care (524037) of Zhanjiang Central People's Hospital, Guangdong Province,