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The cornerstone of nano-drug delivery-the role of EPR effect in human tumors

 Last Update: 2022-06-26
 Source: Internet
 Author: User

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nano precision medical

human anatomy model

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Recently, researchers from Tianjin University have developed an in vitro column model for real-time study of the role of EPR in human kidney tumors through X-ray computed tomography (CT).

Highpermeability and retention effect (enhanced permeability and retention effect, EPR effect) means that some macromolecular substances (such as liposomes, nanoparticles and some macromolecular drugs) of specific sizes are more likely to penetrate into tumor tissues and stay for a long time (and normal Organizational comparison) phenomenon

However, due to the failure of many nanomedicines in clinical transformation and the weak EPR effect, compared with normal organs, nanomedicines only increase the delivery volume by 20-30%

The researchers analyzed the EPR effect of 41 kidney tumors collected from clinical patients, and correlated their EPR effect in human tumors with the EPR effect in animal models.

This study clarified for the first time that the role of EPR in renal tumors is positively correlated with tumor size, and found that male patients have significantly higher tumor EPR effects

References: Yuxun Ding, et al.

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