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A high-fat diet can lead to obesity and metabolic disorders such as diabetes and fatty liver
Elaborate genetic studies in mice have shown that keeping the mitochondrial network in a fused state can overcome obesity caused by a high-fat diet
In their new research, Professor Edinger and her team used their patented water-soluble, oral bioavailability, synthetic sphingolipid SH-BC-893 to inhibit the endolysosomal transport protein required for mitochondrial fission
"The imbalance of leptin and adiponectin hormones that accompanies obesity has brought a difficult battle for people who want to lose weight
The results of this study indicate that SH-BC-893 may be a promising treatment for diet-induced obesity
Professor Edinger said: "This compound works through a new mode of action-if it is safe and effective for humans, it will provide a new weight loss strategy and can also be combined with other treatments
Journal Reference :
Vaishali Jayashankar, Elizabeth Selwan, Sarah E Hancock, Amandine Verlande, Maggie O Goodson, Kazumi H Eckenstein, Giedre Milinkeviciute, Brianna M Hoover, Bin Chen, Angela G Fleischman, Karina S Cramer, Stephen Hanessian, Selma Masri, Nigel Turner, Aimee L Edinger.