Scientists reveal how triclosan damages the gut

Triclosan is an antibacterial substance found in many household items, including toothpaste, toys and thousands of other products . However, a growing body of research is linking triclosan to gut microbiota and intestinal inflammation . An international team of researchers led by the University of North Carolina at Chapel Hill, the University of Massachusetts at Amherst and Hong Kong Baptist University has discovered the bacteria and even the specific enzyme that triggers triclosan's harmful effects, revealing triclosan How it triggers intestinal inflammation . The relevant research results were published in the January 10 issue of "Nature-Communications" . By identifying the bacteria that cause inflammatory bowel disease, new ways to diagnose, prevent and treat inflammatory bowel disease could be developed, said Matthew Redinbo, a professor of chemistry and microbiology at the University of North Carolina at Chapel Hill, one of the corresponding authors of the paper . Previous research has shown that triclosan is toxic, but the new study provides a closer look at how triclosan causes changes in gut microbial populations . 　　The researchers linked specific gut microbial enzymes, specifically the gut microbial beta-glucuronidase (GUS) protein, to triclosan and demonstrated that these enzymes drive triclosan to wreak havoc in the gut . 　　After knowing which bacterial proteins were to blame, the team used a microbiota-targeted inhibitor to stop triclosan from working in the gut . Blocking this process in the mouse gut prevented damage to the colon and symptoms of colitis . 　　The research provides new clues for treating the growing number of patients with inflammatory bowel disease . The study authors suggest that a better understanding of the impact of environmental chemicals on gut health is needed . 　　Triclosan was widely used in antibacterial soaps . But in 2016, the U. S. Food and Drug Administration (FDA) ordered it to be removed from handwashing products used in homes and hospitals over concerns it could lead to more drug-resistant bacteria . 　　But triclosan remains ubiquitous as an ingredient added to cosmetics, yoga mats and sportswear, gear to reduce bacterial contamination . FDA-approved, triclosan is also routinely used in many toothpastes because it has been found to prevent gingivitis . 　　However, triclosan appears to be readily absorbed from the gastrointestinal tract . Given the potential damage to the gut from triclosan and related compounds, their safety should be re-evaluated, the researchers said .   Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Network . Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and text. Readers are only for reference and please Verify the relevant content yourself .   Copyright Notice 1. Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original author . 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicated. Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient evidence. , bio149 will be deleted within 12 hours after confirmation . 3. Users are welcome to submit original articles to 86371366@qq. com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the sender .

Triclosan is an antibacterial substance found in many household items, including toothpaste, toys and thousands of other products
.
However, a growing body of research is linking triclosan to gut microbiota and intestinal inflammation
.


　　An international team of researchers led by the University of North Carolina at Chapel Hill, the University of Massachusetts at Amherst and Hong Kong Baptist University has discovered the bacteria and even the specific enzyme that triggers triclosan's harmful effects, revealing triclosan How it triggers intestinal inflammation
.


　　The relevant research results were published in the January 10 issue of "Nature-Communications"
.


　　By identifying the bacteria that cause inflammatory bowel disease, new ways to diagnose, prevent and treat inflammatory bowel disease could be developed, said Matthew Redinbo, a professor of chemistry and microbiology at the University of North Carolina at Chapel Hill, one of the corresponding authors of the paper
.


　　Previous research has shown that triclosan is toxic, but the new study provides a closer look at how triclosan causes changes in gut microbial populations
.


　　The researchers linked specific gut microbial enzymes, specifically the gut microbial beta-glucuronidase (GUS) protein, to triclosan and demonstrated that these enzymes drive triclosan to wreak havoc in the gut
.


　　After knowing which bacterial proteins were to blame, the team used a microbiota-targeted inhibitor to stop triclosan from working in the gut
.
Blocking this process in the mouse gut prevented damage to the colon and symptoms of colitis
.


　　The research provides new clues for treating the growing number of patients with inflammatory bowel disease
.
The study authors suggest that a better understanding of the impact of environmental chemicals on gut health is needed
.


　　Triclosan was widely used in antibacterial soaps
.
But in 2016, the U.
S.
Food and Drug Administration (FDA) ordered it to be removed from handwashing products used in homes and hospitals over concerns it could lead to more drug-resistant bacteria
.


　　But triclosan remains ubiquitous as an ingredient added to cosmetics, yoga mats and sportswear, gear to reduce bacterial contamination
.
FDA-approved, triclosan is also routinely used in many toothpastes because it has been found to prevent gingivitis
.


　　However, triclosan appears to be readily absorbed from the gastrointestinal tract
.
Given the potential damage to the gut from triclosan and related compounds, their safety should be re-evaluated, the researchers said
.

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Triclosan is an antibacterial substance found in many household items, including toothpaste, toys and thousands of other products
.
However, a growing body of research is linking triclosan to gut microbiota and intestinal inflammation
.


　　An international team of researchers led by the University of North Carolina at Chapel Hill, the University of Massachusetts at Amherst and Hong Kong Baptist University has discovered the bacteria and even the specific enzyme that triggers triclosan's harmful effects, revealing triclosan How it triggers intestinal inflammation
.


　　The relevant research results were published in the January 10 issue of "Nature-Communications"
.


　　By identifying the bacteria that cause inflammatory bowel disease, new ways to diagnose, prevent and treat inflammatory bowel disease could be developed, said Matthew Redinbo, a professor of chemistry and microbiology at the University of North Carolina at Chapel Hill, one of the corresponding authors of the paper
.


　　Previous research has shown that triclosan is toxic, but the new study provides a closer look at how triclosan causes changes in gut microbial populations
.


　　The researchers linked specific gut microbial enzymes, specifically the gut microbial beta-glucuronidase (GUS) protein, to triclosan and demonstrated that these enzymes drive triclosan to wreak havoc in the gut
.


　　After knowing which bacterial proteins were to blame, the team used a microbiota-targeted inhibitor to stop triclosan from working in the gut
.
Blocking this process in the mouse gut prevented damage to the colon and symptoms of colitis
.


　　The research provides new clues for treating the growing number of patients with inflammatory bowel disease
.
The study authors suggest that a better understanding of the impact of environmental chemicals on gut health is needed
.


　　Triclosan was widely used in antibacterial soaps
.
But in 2016, the U.
S.
Food and Drug Administration (FDA) ordered it to be removed from handwashing products used in homes and hospitals over concerns it could lead to more drug-resistant bacteria
.


　　But triclosan remains ubiquitous as an ingredient added to cosmetics, yoga mats and sportswear, gear to reduce bacterial contamination
.
FDA-approved, triclosan is also routinely used in many toothpastes because it has been found to prevent gingivitis
.


　　However, triclosan appears to be readily absorbed from the gastrointestinal tract
.
Given the potential damage to the gut from triclosan and related compounds, their safety should be re-evaluated, the researchers said
.

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