Rotavirus Entry into Tissue Culture Cells
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Last Update: 2021-02-16
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Source: Internet
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Author: User
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Rotavirus (RV) is a triple-protein-layered icosahedral virus, for which studies have established that the two outer-layer proteins, viral protein 4 (VP4) and viral protein 7 (VP7), are required for viral infectivity (
1
,
2
). VP7, a glycoprotein, is the major component of the outer-layer, but its role in viral entry is unclear. VP4 forms dimers extending out from the VP7-coated viral surface (
3
,
4
) and have been shown to be a determinant of host range and virulence, and is directly involved in cell attachment and RV entry into cells (
5
–
8
). Proteolytic cleavage of VP4 into two noncovalently associated subunits, VP8* and VP5* (
2
,
9
,
10
), significantly enhances viral infectivity (
11
–
13
).
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