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Ribozyme-Mediated Inhibition of Cell Proliferation: A Model for Identifying and Refining a Therapeutic Ribozyme

 Last Update: 2021-02-16
 Source: Internet
 Author: User

Tags

base sequence dna

substrate specificity

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The discovery of enzymatic RNA molecules, termed ribozymes (
1
,
2
), fundamentally changed our view of the function of RNA in chemistry, biology, and medicine. Naturally occurring enzymatic RNA molecules catalyze sequence-specific RNA processing. The sequence specificity is determined by the ability of the ribozyme to base pair with nucleotides near the cleavage site of the target RNA; by altering the substrate recognition sequences, intramolecular,
cis
-cleaving ribozymes can be engineered to cleave in
trans
(reviewed in Cech, T. R., [
3
]). In theory, ribozymes can be engineered to cleave any RNA species, site-specifically, in the background of cellular RNA. This cleavage event renders the target mRNA unstable and abrogates protein expression.

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