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As we all know, exercise makes people feel relaxed and happy
As we all know, exercise makes people feel relaxed and happy
In addition, animal experiments have also shown that exercise can alleviate injuries, so researchers speculate that exercise can be anti-inflammatory
So, can exercise help fight inflammation?
A new study recently published in Gut Microbes shows that exercise can produce high levels of endocannabinoids in people with arthritis, which mediate the production of anti-inflammatory substances by gut probiotics that reduce pain
A new study recently published in Gut Microbes shows that exercise can produce high levels of endocannabinoids in people with arthritis, which mediate the production of anti-inflammatory substances by gut probiotics that reduce pain
Participants were asked to fast at least from 9 o'clock the night before (the minimum fasting time was 11.
It was found that the short-chain fatty acids in the serum of the exercise group were significantly increased: butyric acid was 1.
To make the results more convincing, the researchers also set up a healthy control group, a total of 35 people over the age of 18, who also did not do any exercise, and collected their serum samples for the test in the same way
In addition to the increase in the content of anti-inflammatory substance butyric acid, the content of pro-inflammatory cytokines in the serum of the exercise group was also found to decrease, such as IL-13 decreased by 38% compared with the control group, and IL-4 decreased compared with the control group.
In addition to the increase in the content of anti-inflammatory substance butyric acid, the content of pro-inflammatory cytokines in the serum of the exercise group was also found to decrease, such as IL-13 decreased by 38% compared with the control group, and IL-4 decreased compared with the control group.
Short-chain fatty acids such as butyric acid are produced by intestinal probiotics, so the researchers then collected the feces of the control and exercise groups in the same way and tested their intestinal microbial content, and found that the intestinal probiotics of the exercise group were as Increased abundance of Bifidobacterium, Coprococcus 3, and Faecalibacterium, which have been shown to play an important role in cancer prevention, and Collinsella Abundance was significantly reduced, and this bacterium is often found in high abundance in the gut of patients with nonalcoholic steatohepatitis, type 2 diabetes,
Why does exercise increase the abundance of probiotics in the gut and produce anti-inflammatory substances?
Further analysis by the researchers found that exercise produced large amounts of endocannabinoids in the arthritic patients, with arachidonic acid (AEA) 1.
Further analysis by the researchers found that exercise produced large amounts of endocannabinoids in the arthritic patients, with arachidonic acid (AEA) 1.
After testing the gene expression levels of endocannabinoids and their receptors and short-chain fatty acid receptors, they found that endocannabinoids AEA, OEA, etc.
They confirmed that these elevated endocannabinoids mediated the production of high levels of short-chain fatty acids such as butyrate by gut probiotics to fight inflammation, thus reducing pain in patients! Squares indicate size; blue indicates positive correlation; red indicates negative correlation Although the researchers tested only in arthritis patients, the associations of endocannabinoids, short-chain fatty acids, and pro-inflammatory cytokines were also found in the healthy group The verification shows that this result is universal, which means that exercise can reduce or even cure other inflammatory diseases
Although the study did not describe whether the arthritis patients were cured, after all, the experiment was only 6 weeks old, but the symptoms of the patients were actually relieved
Other studies have also come to support, walking can achieve the purpose of maintaining health, and does not require a specific speed, just at the normal walking speed
.
A recent article published in JAMA Network Open confirmed that people who walked about 7,000 steps per day had a 50% to 70% lower risk of dying from all causes during an 11-year follow-up period !
A recent article published in JAMA Network Open confirmed that people who walked about 7,000 steps per day had a 50% to 70% lower risk of dying from all causes during an 11-year follow-up period !No need to go to the gym, no need to buy equipment, and no need for a specific time, just walk as much as you can to stay healthy, scientists say, walk more, live longer
.
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References References References [1] The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids, Gut Microbes, DOI: 10.
1080/19490976.
2021.
1997559 [2] Amanda E.
Paluch et al, Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study, JAMA Network Open (2021).
DOI: 10.
1001/jamanetworkopen.
2021.
24516
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