Protein also has a "dual personality"
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Last Update: 2013-09-29
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Source: Internet
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Author: User
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London, Sept 26, Xinhua (reporter Liu Shilei) the hero of the novel "doctor incarnate" is a typical "double personality" New research has found that a protein has similar duality, sometimes it can inhibit bad cells, sometimes it can promote the growth of cancer cells In the future, the protein could be used to develop new anticancer drugs by "suppressing evil and promoting good" A protein called E2F plays an important role in cell growth, differentiation and death, an international research team led by researchers from Oxford University reported Tuesday Under normal circumstances, it can monitor DNA damage in cells, and start the cell death process, so that the damaged cells no longer differentiate and proliferate, but gradually apoptosis But in cancer cells, the monitoring function of "E2F" is often out of control, making cancer cells not only not killed, but also crazy growth and spread The researchers further found that two enzymes play a key role in the monitoring mechanism of "E2F" They will compete with each other to identify the "good" or "bad" of the cell, so as to decide whether to promote the cell growth or guide it to death Nick La tonger, a professor at Oxford University, said that in the future, it is expected to use this property to develop new drugs, so that "E2F" will no longer show the "bad" side, so as to correctly identify and kill cancer cells The research is published in the new issue of molecular cell in the United States.
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