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6.
Production process
1) Benzyl chloride method
(1) Condensation
.
The benzene and 139kg 253kg zinc chloride solution (density 1.
(2) Oxidation
.
Add the crude diphenylmethane and several magnetic pieces into the oxidation reaction kettle in sequence, increase the temperature of 106-116°C, add 140kg of nitric acid (relative density 1.
2) Carbon tetrachloride method
Add 2/3 of anhydrous carbon tetrachloride and anhydrous aluminum trichloride into the reaction pot, cool to 10-15°C, and add 1/12 of benzene to react
.
Continue to cool to 5-10°C, add dropwise the remaining 1/3 of the mixed solution of carbon tetrachloride and 11/12 of benzene, and add it in about 1 hour
7.
Laboratory preparation method
Carbon tetrachloride method: Add 134g of anhydrous aluminum trichloride (AlC3) and 450g of dry CCl4 into a 2000mL three-necked flask
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An absorption (HC1) device is terminated on the reflux condenser
8.
Product Standard
9.
Quality inspection
Assay: the hydroxylamine method is used
.
Accurately weigh 1g sample, put it into a 250mL Erlenmeyer flask, add 75mL of hydroxylamine solution (20g hydroxylamine + 40mL water, dilute 400L with ethanol, and add 0.
Gas chromatography can also be used to determine the content
.
10.
Product use
Benzophenone is an intermediate of ultraviolet absorbers, organic pigments, medicines, fragrances, and pesticides
.
The pharmaceutical industry for the production of bicyclic Piperidine benztropine hydrobromide, diphenhydramine hydrochloride and the like
11.
Safety measures
(1) It has general ketone narcotic effects
.
The highest reference dosage for edible spices: 0.
(2) During the production process, the equipment should be airtight, the workshop should be well ventilated, and the operators should wear labor protection equipment
(3) Sealed storage, should be stored separately from the oxidant
.
