Nature sub-journal: Causal relationship between blood metabolites and gut microbiota

Zhang Tao, Jia Huijue, etc. of Shenzhen BGI Life Sciences Research Institute published an article Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome in the journal Nature Genetics. ) . We performed a two-way Mendelian randomization analysis of genome-wide, whole-genome, anthropometric, and blood-metabolic trait data from 3432 Chinese . The researchers identified 58 causal relationships between the gut microbiome and blood metabolites and replicated 43 of them . Increased relative abundance of Oscillibacter and Alistipes in feces was causally associated with decreased triglyceride concentrations . Conversely, blood metabolites such as glutamate appeared to reduce fecal Oxalobacter, while members of Proteobacteria were affected by metabolites such as 5-methyltetrahydrofolate, alanine, glutamate and selenium influence . Two-sample Mendelian randomization using Japan Biobank data partially confirmed the triglyceride and uric acid results and also provided causal support for published fecal bacterial markers of cancer and cardiovascular disease . This study illustrates the value of human genetic information to help prioritize mechanistic and clinical studies of gut microbial signatures . 　　The research results were published online in the international academic journal Nature Genetics on January 3, 2022 .   Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Network . Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and text. Readers are only for reference and please Verify the relevant content yourself .   Copyright Notice 1. Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original author . 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicated. Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient evidence. , bio149 will be deleted within 12 hours after confirmation . 3. Users are welcome to submit original articles to 86371366@qq. com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the sender .

Zhang Tao, Jia Huijue, etc.
of Shenzhen BGI Life Sciences Research Institute published an article Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome in the journal Nature Genetics, and conducted Mendelian randomization analysis (MR, Mendelian Randomization) of human gut microbiome )
.


　　We performed a two-way Mendelian randomization analysis of genome-wide, whole-genome, anthropometric, and blood-metabolic trait data from 3432 Chinese
.
The researchers identified 58 causal relationships between the gut microbiome and blood metabolites and replicated 43 of them
.
Increased relative abundance of Oscillibacter and Alistipes in feces was causally associated with decreased triglyceride concentrations
.
Conversely, blood metabolites such as glutamate appeared to reduce fecal Oxalobacter, while members of Proteobacteria were affected by metabolites such as 5-methyltetrahydrofolate, alanine, glutamate and selenium influence
.


　　Two-sample Mendelian randomization using data from the Japan Biobank partially confirmed the results for triglycerides and uric acid, and also provided causal support for published fecal bacterial markers of cancer and cardiovascular disease
.
This study illustrates the value of human genetic information to help prioritize mechanistic and clinical studies of gut microbial signatures
.


　　The research results were published online in the international academic journal Nature Genetics on January 3, 2022
.

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Zhang Tao, Jia Huijue, etc.
of Shenzhen BGI Life Sciences Research Institute published an article Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome in the journal Nature Genetics, and conducted Mendelian randomization analysis (MR, Mendelian Randomization) of human gut microbiome )
.


　　We performed a two-way Mendelian randomization analysis of genome-wide, whole-genome, anthropometric, and blood-metabolic trait data from 3432 Chinese
.
The researchers identified 58 causal relationships between the gut microbiome and blood metabolites and replicated 43 of them
.
Increased relative abundance of Oscillibacter and Alistipes in feces was causally associated with decreased triglyceride concentrations
.
Conversely, blood metabolites such as glutamate appeared to reduce fecal Oxalobacter, while members of Proteobacteria were affected by metabolites such as 5-methyltetrahydrofolate, alanine, glutamate and selenium influence
.


　　Two-sample Mendelian randomization using data from the Japan Biobank partially confirmed the results for triglycerides and uric acid, and also provided causal support for published fecal bacterial markers of cancer and cardiovascular disease
.
This study illustrates the value of human genetic information to help prioritize mechanistic and clinical studies of gut microbial signatures
.


　　The research results were published online in the international academic journal Nature Genetics on January 3, 2022
.

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