 Home > Biochemistry News > Microbiology News > Nat Med | Liu Quan/Wang Wei/Qian Jun teamed up to discover a new species of Neiro virus-Songling virus

Nat Med | Liu Quan/Wang Wei/Qian Jun teamed up to discover a new species of Neiro virus-Songling virus

 Last Update: 2021-03-25
 Source: Internet
 Author: User

Tags

5 6 models

troy new york university

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Editor | Xi tick is an important pathogen transmission vector.
The infectious viruses include forest encephalitis virus, Xinjiang hemorrhagic fever virus, fever with thrombocytopenia syndrome virus, Nairobi sheep disease virus and Alongshan virus.

On February 18, 2021, Professor Liu Quan of Foshan University of Science and Technology, Dean Wang Wei of Inner Mongolia Forestry General Hospital and Professor Qian Jun of Zhongshan Medical College of Sun Yat-Sen University and other research teams jointly published an article Identification of a new orthonairovirus associated in Nature Medicine with human febrile illness in China.

The study isolated and identified a new tick-borne virus-Songling virus (SGLV) from tick bite patients, and suggested that the virus infection may cause the patient to develop fever, headache and other clinical symptoms.

The researchers first performed high-throughput sequencing on the blood of a patient with unexplained fever after a tick bite and found that the patient was suspected of being infected with a new Bunia virus.

Subsequently, by isolating and cultivating the virus, and analyzing the whole genome sequence of the virus, it was found that the genome characteristics and morphological structure of the virus were similar to those of known viruses of the genus Neiro virus, but formed a separate phylogenetic tree.
Branch.

Songling virus belongs to the Bunyavirus order Neiroviridae, a member of the genus Orneirovirus.
The genome includes three fragments of L, M, and S.
The sequence homology with known orthoneiroviruses is 46.
5–65.
7%.

Later, the researchers found through retrospective analysis that all patients involved in SGLV infection have a history of tick bites; the incubation period of the disease is about 6 days; the main clinical symptoms are headache, fever, depression, fatigue, and dizziness; some patients can be detected in vivo To specific antibodies.

In addition, the researchers tested the Ixodes and Haemophilus ticks in Northeast China and found that they were infected with SGLV, suggesting its importance in the spread of SGLV.

In summary, Chinese scholars have discovered a new Neiro virus, which is related to febrile diseases in Northeast China.

The results of the study indicate that Songling Virus (SGLV) may be the cause of a previously unknown febrile disease, and more research should be conducted to determine the geographic distribution of this disease outside its current recognition area.

Figure 1.
SGLV genome structure, evolutionary relationship and virus morphology Original link: https:// Platemaker: 11 References 1.
Ma J, Lv X.
- L, Zhang X, Han S.
-Z, Wang Z.
-D, Li L, Sun H.
-T, Ma L.
-X, Cheng Z.
-L, Shao J.
-W, Chen C, Zhao Y.
-H, Sui L, Liu L.
-N, Qian J, Wang W, Liu Q.
Identification of a new orthonairovirus associated with human febrile illness in China.
Nature Medicine, 2021.
doi: 10.
1038/s41591-020-01228-y .
2.
Wang ZD, Wang B, Wei F, Han SZ, Zhang L, Yang ZT, Yan Y, Lv XL, Li L, Wang SC, Song MX, Zhang HJ, Huang SJ, Chen J, Huang FQ, Li S , Liu HH, Hong J, Jin YL, Wang W, Zhou JY, Liu Q.
A New Segmented Virus Associated with Human Febrile Illness in China.
N Engl J Med.
2019 May 30;380(22):2116-2125.
doi : 10.
1056/NEJMoa1805068.
PMID: 31141633.
3.
Liu Q, He B, Huang SY, Wei F, Zhu XQ.
Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis.
Lancet Infect Dis.
2014 Aug;14(8):763-772.
doi: 10.
1016/S1473-3099(14)70718-2.
4.
Liu X, Zhang X, Wang Z, Dong Z, Xie S, Jiang M, Song R , Ma J, Chen S, Chen K, Zhang H, Si X, Li C, Jin N, Wang Y, Liu Q.
A Tentative Tamdy Orthonairovirus Related to Febrile Illness in Northwestern China.
Clin Infect Dis.
2020 May 6;70( 10):2155-2160.
doi: 10.
1093/cid/ciz602.
PMID: 31260510.
5.
Dong Z, Yang M, Wang Z, Zhao S, Xie S, Yang Y, Liu G, Zhao S, Xie J, Liu Q, Wang Y.
Human Tacheng Tick Virus 2 Infection, China, 2019.
Emerg Infect Dis.
2021 Feb;27(2):594-598.
doi: 10.
3201/eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr;21(4):718-20.
doi: 10.
3201/eid2104.
141602.
Zhang X, Wang Z, Dong Z, Xie S, Jiang M, Song R, Ma J, Chen S, Chen K, Zhang H, Si X, Li C, Jin N, Wang Y, Liu Q.
A Tentative Tamdy Orthonairovirus Related to Febrile Illness in Northwestern China.
Clin Infect Dis.
2020 May 6;70(10):2155-2160.
doi: 10.
1093/cid/ciz602.
PMID: 31260510.
5.
Dong Z, Yang M, Wang Z, Zhao S, Xie S , Yang Y, Liu G, Zhao S, Xie J, Liu Q, Wang Y.
Human Tacheng Tick Virus 2 Infection, China, 2019.
Emerg Infect Dis.
2021 Feb;27(2):594-598.
doi: 10.
3201/ eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr;21(4): 718-20.
doi: 10.
3201/eid2104.
141602.
Zhang X, Wang Z, Dong Z, Xie S, Jiang M, Song R, Ma J, Chen S, Chen K, Zhang H, Si X, Li C, Jin N, Wang Y, Liu Q.
A Tentative Tamdy Orthonairovirus Related to Febrile Illness in Northwestern China.
Clin Infect Dis.
2020 May 6;70(10):2155-2160.
doi: 10.
1093/cid/ciz602.
PMID: 31260510.
5.
Dong Z, Yang M, Wang Z, Zhao S, Xie S , Yang Y, Liu G, Zhao S, Xie J, Liu Q, Wang Y.
Human Tacheng Tick Virus 2 Infection, China, 2019.
Emerg Infect Dis.
2021 Feb;27(2):594-598.
doi: 10.
3201/ eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr;21(4): 718-20.
doi: 10.
3201/eid2104.
141602.
A Tentative Tamdy Orthonairovirus Related to Febrile Illness in Northwestern China.
Clin Infect Dis.
2020 May 6;70(10):2155-2160.
doi: 10.
1093/cid/ciz602.
PMID: 31260510.
5.
Dong Z, Yang M, Wang Z, Zhao S, Xie S, Yang Y, Liu G, Zhao S, Xie J, Liu Q, Wang Y.
Human Tacheng Tick Virus 2 Infection, China, 2019.
Emerg Infect Dis.
2021 Feb;27(2):594-598 .
doi: 10.
3201/eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr; 21(4):718-20.
doi: 10.
3201/eid2104.
141602.
A Tentative Tamdy Orthonairovirus Related to Febrile Illness in Northwestern China.
Clin Infect Dis.
2020 May 6;70(10):2155-2160.
doi: 10.
1093/cid/ciz602.
PMID: 31260510.
5.
Dong Z, Yang M, Wang Z, Zhao S, Xie S, Yang Y, Liu G, Zhao S, Xie J, Liu Q, Wang Y.
Human Tacheng Tick Virus 2 Infection, China, 2019.
Emerg Infect Dis.
2021 Feb;27(2):594-598 .
doi: 10.
3201/eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr; 21(4):718-20.
doi: 10.
3201/eid2104.
141602.
2021 Feb;27(2):594-598.
doi: 10.
3201/eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr;21(4):718-20.
doi: 10.
3201/eid2104.
141602.
2021 Feb;27(2):594-598.
doi: 10.
3201/eid2702.
191486.
6.
Gong S, He B, Wang Z, Shang L, Wei F, Liu Q, Tu C.
Nairobi sheep disease virus RNA in ixodid ticks, China, 2013.
Emerg Infect Dis.
2015 Apr;21(4):718-20.
doi: 10.
3201/eid2104.
141602.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.