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Certain nonconserved genotypic and phenotypic characteristics of
H. pylori
are associated with increased risk of peptic ulceration in the human host. These characteristics can be divided into two groups: first, those relating to vacuolating cytotoxin activity (
1
,
2
), and differences in the gene encoding the cytotoxin,
vacA
(
3
); second, those relating to the cytotoxin-associated gene,
cagA
(
4
,
5
).