Molecular & Cellular Proteomics Wang Yingchun's research group, Institute of Genetics, Chinese Academy of Sciences, systematically reveals the light/dark-regulated protein degradation of cyanobacteria

Light is necessary for photosynthetic organisms (including higher plants and cyanobacteria), and is involved in regulating protein synthesis and degradation
.

Light-regulated protein degradation is an important mechanism for protein quality control in photosynthetic organisms.
The most typical and most in-depth study is the D1 protein of the photosystem II reaction center.
Its photo-induced degradation and repair are the guarantee for the continuous progress of photosynthesis
.

In addition, it is unclear whether there are a large number of undiscovered protein degradation and repair regulated by light
.

The Wang Yingchun research group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences used quantitative proteomics to systematically identify the protein of the model cyanobacterium Synechocystis PCC 6803 that is significantly degraded in light or dark
.

The results showed that there were 79 protein tables whose degradation was obviously regulated by light, including some proteins that can participate in the structure or function of photosystem II, quinone binding, and NAD(P)H dehydrogenase-related proteins
.

In addition, the degradation of 31 proteins depends on darkness, and the degradation of 71 proteins can be carried out in light and darkness
.

Further studies have shown that the degradation of multiple light-regulated proteins is also regulated by the redox state in the cell and the redox state of the plastoquinone (PQ) pool on the photosynthetic electron transport chain
.

The reduced state promotes and the oxidized state inhibits degradation
.

This research provides important resources and clues for the research on protein quality control of photosynthetic organisms
.

Figure: Proteomics technology to identify light and dark-regulated protein degradation in cyanobacteria.
The research results were published online in Molecular & Cellular Proteomics (DOI:10.
1016/j.
mcpro.
2021.
100162) on October 13, 2021
.

Chen Weiyang, a doctoral student in Wang Yingchun's research group, is the first author of the paper
.

This work was supported by the National Natural Science Foundation of China and the Ministry of Science and Technology
.

Image source: Plant Science SCI Public Account Plant Biotechnology Pbj Exchange Group In order to more effectively help the majority of scientific researchers to obtain relevant information, Plant Biotechnology Pbj has established a WeChat group, Plant Biotechnology Journal submissions and document-related issues, public accounts The published content and public account submission questions will be concentrated in the group for answers, and at the same time, academic exchanges and collision thinking in the group are encouraged
.

In order to ensure a good discussion environment in the group, please add the editor WeChat first, scan the QR code to add, and then we will promptly invite you to join the group
.

Tips: When adding the editor WeChat and after joining the group, please be sure to note the school or unit + name, and the PI should be noted at the end, and we will invite you to join the PI group
.