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MIT: Polylactic-glycolic acid copolymer microparticles make "self-enhancing" vaccine

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Scientists at the Massachusetts Institute of Technology (MIT) report in the recent journal Science Advances that they are developing a single-dose self-boosting vacci.

It is reported that this new vaccine is made of poly(lactic-co-glycolic acid) (PLGA) particl.

Particles are similar to small coffee cups sealed with li.

Jaklenz pointed out that the polymer will gradually be decomposed by water, causing the "lid" to become porous, and soon the "cup lid" will separate and the vaccine will flow o.

However, the researchers also noted that when the microparticles are broken down by water, the lactic and glycolic acids released can cause an increase in the acidity of the environment, destroying the drug, and they are currently investigating ways to counteract this effect and improve microparticle stabili.

The research team has tested a self-boosting polio vaccine in animals, which usually has to be administered in two to four dos.

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