Lactobacillus casei Zhang: A new breakthrough in protecting liver

On February 27, 2021, the famous Hong Kong movie star Wu Mengda passed away from liver cancer, which caused mourning across the network for a while. Liver disease has once again entered everyone's attention. This is a health problem that is very worthy of attention. Authoritative data show that my country is a major liver disease country, and about 300 million people suffer from liver damage. If it is not controlled, liver cirrhosis and even liver cancer will occur! It coincides with the arrival of spring, and it is a good season to nourish the liver and protect the liver. Let’s talk about what to do with liver damage today. The liver is one of the body's largest immune organs, which can metabolize toxic substances in the body and excrete it from the body. As people’s lifestyle changes, such as staying up late, skipping breakfast, drinking and socializing, will put a lot of pressure on the liver; people who like to build muscle may also consume protein powder improperly during their daily exercise. And cause potential damage to the liver. When the level of transaminase is increased during the physical examination, it indicates that your liver is damaged!Liver health is closely related to the health of the intestinal flora. There is a close symbiotic relationship between the intestinal flora and the host. Maintaining the balance of the intestinal flora is vital to human health. Conventional treatments for liver injury include drug therapy, liver transplantation, etc. However, there are problems such as secondary injury and related rejection reactions, which will reduce the cure rate. 　　The latest research has found that the onset of liver disease is related to the growth of endotoxins in the body by gram-negative bacteria. Damage to the intestinal barrier function will lead to liver loss; probiotics can reduce acute liver damage caused by endotoxins. 　　Relief of liver inflammation by Lactobacillus casei Zhang 　　1. Serum indicators 　　Lactobacillus casei Zhang can effectively reduce serum endotoxin, interleukin 1β (IL-1β), serum tumor necrosis factor ɑ (TNF-α) and nitric oxide (NO). ) Level to slow down the inflammation of the liver. Compared with the conventional treatment drug dexamethasone, it has a similar relief effect. 　　2. Histological evaluation 　　Lactobacillus casei Zhang can effectively improve the histological assessment of liver damage, and the structure of liver lobules is well arranged. Lactobacillus casei Zhang can also repair the structure of the intestine, relieve the damage of the villi structure and the necrosis of epithelial cells caused by liver damage, and relieve the swelling of the intestinal mucosa, significantly reducing the level of pathology. 　　3. Determination of liver inflammation mediators 　　Lactobacillus casei Zhang can significantly reduce the activity of liver myeloperoxidase (MPO) and effectively regulate liver inflammation mediators. 　　4. Western blot analysis　　Lactobacillus casei Zhang intervention significantly increased the expression of TLR2 and TLR9 to achieve anti-inflammatory effects. 　　5. Intestinal flora analysis 　　Lactobacillus casei Zhang intervention significantly increased the content of beneficial bacteria such as Lactobacillus and Bifidobacterium, and reduced the content of pathogenic bacteria such as Clostridium and Bacteroides fragilis induced by liver inflammation. However, in the intervention treatment of the conventional drug dexamethasone, it is impossible to observe the regulating effect on the intestinal flora. 　　Summary　　Lactobacillus casei Zhang can significantly improve acute liver injury and liver inflammation. Serum endotoxin levels, related histological scores and MPO levels have all been significantly improved. Compared with the conventional drug dexamethasone, Lactobacillus casei Zhang can also increase the content of beneficial bacteria and reduce the content of pathogenic bacteria to achieve regulation of intestinal bacteria. Group and maintain the effect of intestinal flora balance. 　　The star strain, Lactobacillus casei Zhang 　　, was isolated from natural fermented mare milk in the Xilin Gol Prairie in Inner Mongolia in 2002. It is the first lactic acid bacteria in China that has completed whole-genome sequencing. Through scientific research, it has been found that Lactobacillus casei Zhang can regulate the intestinal flora, improve immunity, prevent upper respiratory tract infections in middle-aged and elderly people, and regulate the rejuvenation of intestinal flora. As of January 2021, 16 related patents have been applied for Lactobacillus casei Zhang and 172 papers have been published. Lactobacillus casei Zhang gene map Article published in: Eur J Nutr (2016) 55:821–831      Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com. The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself.      Copyright Notice    1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author. 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and clearly indicate the source and author. 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　　On February 27, 2021, the famous Hong Kong movie star Wu Mengda passed away from liver cancer, which caused mourning across the network for a while.
Liver disease has once again entered everyone's attention.
This is a health problem that is very worthy of attention.
Authoritative data show that my country is a major liver disease country, and about 300 million people suffer from liver damage.
If it is not controlled, liver cirrhosis and even liver cancer will occur! It coincides with the arrival of spring, and it is a good season to nourish the liver and protect the liver.
Let’s talk about what to do with liver damage today.
　　The liver is one of the body's largest immune organs, which can metabolize toxic substances in the body and excrete it from the body.
As people’s lifestyle changes, such as staying up late, skipping breakfast, drinking and socializing, will put a lot of pressure on the liver; people who like to build muscle may also consume protein powder improperly during their daily exercise.
And cause potential damage to the liver.
When the level of transaminase is increased during the physical examination, it indicates that your liver is damaged! 　　Liver health is closely related to the health of the intestinal flora.
There is a close symbiotic relationship between the intestinal flora and the host.
Maintaining the balance of the intestinal flora is vital to human health.
Conventional treatments for liver injury include drug therapy, liver transplantation, etc.
However, there are problems such as secondary injury and related rejection reactions, which will reduce the cure rate.
　　The latest research has found that the onset of liver disease is related to the growth of endotoxins in the body by gram-negative bacteria.
Damage to the intestinal barrier function will lead to liver loss; probiotics can reduce acute liver damage caused by endotoxins.
　　Relief of liver inflammation by Lactobacillus casei Zhang 　　1.
Serum indicators 　　Lactobacillus casei Zhang can effectively reduce serum endotoxin, interleukin 1β (IL-1β), serum tumor necrosis factor ɑ (TNF-α) and nitric oxide (NO).
) Level to slow down the inflammation of the liver.
Compared with the conventional treatment drug dexamethasone, it has a similar relief effect.


　　Lactobacillus casei Zhang can effectively improve the histological assessment of liver damage, and the structure of liver lobules is well arranged.
Lactobacillus casei Zhang can also repair the structure of the intestine, relieve the damage of the villi structure and the necrosis of epithelial cells caused by liver damage, and relieve the swelling of the intestinal mucosa, significantly reducing the level of pathology.
　　3.
Determination of liver inflammation mediators 　　Lactobacillus casei Zhang can significantly reduce the activity of liver myeloperoxidase (MPO) and effectively regulate liver inflammation mediators.
　　4.
Western blot analysis　　Lactobacillus casei Zhang intervention significantly increased the expression of TLR2 and TLR9 to achieve anti-inflammatory effects.


　　5.
Intestinal flora analysis 　　Lactobacillus casei Zhang intervention significantly increased the content of beneficial bacteria such as Lactobacillus and Bifidobacterium, and reduced the content of pathogenic bacteria such as Clostridium and Bacteroides fragilis induced by liver inflammation.
However, in the intervention treatment of the conventional drug dexamethasone, it is impossible to observe the regulating effect on the intestinal flora.

　　Summary　　Lactobacillus casei Zhang can significantly improve acute liver injury and liver inflammation.
Serum endotoxin levels, related histological scores and MPO levels have all been significantly improved.
Compared with the conventional drug dexamethasone, Lactobacillus casei Zhang can also increase the content of beneficial bacteria and reduce the content of pathogenic bacteria to achieve regulation of intestinal bacteria.
Group and maintain the effect of intestinal flora balance.
　　The star strain, Lactobacillus casei Zhang 　　, was isolated from natural fermented mare milk in the Xilin Gol Prairie in Inner Mongolia in 2002.
It is the first lactic acid bacteria in China that has completed whole-genome sequencing.
Through scientific research, it has been found that Lactobacillus casei Zhang can regulate the intestinal flora, improve immunity, prevent upper respiratory tract infections in middle-aged and elderly people, and regulate the rejuvenation of intestinal flora.
As of January 2021, 16 related patents have been applied for Lactobacillus casei Zhang and 172 papers have been published.

Article published in: Eur J Nutr (2016) 55:821–831

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　　On February 27, 2021, the famous Hong Kong movie star Wu Mengda passed away from liver cancer, which caused mourning across the network for a while.
Liver disease has once again entered everyone's attention.
This is a health problem that is very worthy of attention.
Authoritative data show that my country is a major liver disease country, and about 300 million people suffer from liver damage.
If it is not controlled, liver cirrhosis and even liver cancer will occur! It coincides with the arrival of spring, and it is a good season to nourish the liver and protect the liver.
Let’s talk about what to do with liver damage today.
　　The liver is one of the body's largest immune organs, which can metabolize toxic substances in the body and excrete it from the body.
As people’s lifestyle changes, such as staying up late, skipping breakfast, drinking and socializing, will put a lot of pressure on the liver; people who like to build muscle may also consume protein powder improperly during their daily exercise.
And cause potential damage to the liver.
When the level of transaminase is increased during the physical examination, it indicates that your liver is damaged! 　　Liver health is closely related to the health of the intestinal flora.
There is a close symbiotic relationship between the intestinal flora and the host.
Maintaining the balance of the intestinal flora is vital to human health.
Conventional treatments for liver injury include drug therapy, liver transplantation, etc.
However, there are problems such as secondary injury and related rejection reactions, which will reduce the cure rate.
　　The latest research has found that the onset of liver disease is related to the growth of endotoxins in the body by gram-negative bacteria.
Damage to the intestinal barrier function will lead to liver loss; probiotics can reduce acute liver damage caused by endotoxins.
　　Relief of liver inflammation by Lactobacillus casei Zhang 　　1.
Serum indicators 　　Lactobacillus casei Zhang can effectively reduce serum endotoxin, interleukin 1β (IL-1β), serum tumor necrosis factor ɑ (TNF-α) and nitric oxide (NO).
) Level to slow down the inflammation of the liver.
Compared with the conventional treatment drug dexamethasone, it has a similar relief effect.


　　Lactobacillus casei Zhang can effectively improve the histological assessment of liver damage, and the structure of liver lobules is well arranged.
Lactobacillus casei Zhang can also repair the structure of the intestine, relieve the damage of the villi structure and the necrosis of epithelial cells caused by liver damage, and relieve the swelling of the intestinal mucosa, significantly reducing the level of pathology.
　　3.
Determination of liver inflammation mediators 　　Lactobacillus casei Zhang can significantly reduce the activity of liver myeloperoxidase (MPO) and effectively regulate liver inflammation mediators.
　　4.
Western blot analysis　　Lactobacillus casei Zhang intervention significantly increased the expression of TLR2 and TLR9 to achieve anti-inflammatory effects.


　　5.
Intestinal flora analysis 　　Lactobacillus casei Zhang intervention significantly increased the content of beneficial bacteria such as Lactobacillus and Bifidobacterium, and reduced the content of pathogenic bacteria such as Clostridium and Bacteroides fragilis induced by liver inflammation.
However, in the intervention treatment of the conventional drug dexamethasone, it is impossible to observe the regulating effect on the intestinal flora.

　　Summary　　Lactobacillus casei Zhang can significantly improve acute liver injury and liver inflammation.
Serum endotoxin levels, related histological scores and MPO levels have all been significantly improved.
Compared with the conventional drug dexamethasone, Lactobacillus casei Zhang can also increase the content of beneficial bacteria and reduce the content of pathogenic bacteria to achieve regulation of intestinal bacteria.
Group and maintain the effect of intestinal flora balance.
　　The star strain, Lactobacillus casei Zhang 　　, was isolated from natural fermented mare milk in the Xilin Gol Prairie in Inner Mongolia in 2002.
It is the first lactic acid bacteria in China that has completed whole-genome sequencing.
Through scientific research, it has been found that Lactobacillus casei Zhang can regulate the intestinal flora, improve immunity, prevent upper respiratory tract infections in middle-aged and elderly people, and regulate the rejuvenation of intestinal flora.
As of January 2021, 16 related patents have been applied for Lactobacillus casei Zhang and 172 papers have been published.

Article published in: Eur J Nutr (2016) 55:821–831

---

　　On February 27, 2021, the famous Hong Kong movie star Wu Mengda passed away from liver cancer, which caused mourning across the network for a while.
Liver disease has once again entered everyone's attention.
This is a health problem that is very worthy of attention.
Authoritative data show that my country is a major liver disease country, and about 300 million people suffer from liver damage.
If it is not controlled, liver cirrhosis and even liver cancer will occur! It coincides with the arrival of spring, and it is a good season to nourish the liver and protect the liver.
Let’s talk about what to do with liver damage today.
　　The liver is one of the body's largest immune organs, which can metabolize toxic substances in the body and excrete it from the body.
As people’s lifestyle changes, such as staying up late, skipping breakfast, drinking and socializing, will put a lot of pressure on the liver; people who like to build muscle may also consume protein powder improperly during their daily exercise.
And cause potential damage to the liver.
When the level of transaminase is increased during the physical examination, it indicates that your liver is damaged! 　　Liver health is closely related to the health of the intestinal flora.
There is a close symbiotic relationship between the intestinal flora and the host.
Maintaining the balance of the intestinal flora is vital to human health.
Conventional treatments for liver injury include drug therapy, liver transplantation, etc.
However, there are problems such as secondary injury and related rejection reactions, which will reduce the cure rate.
　　The latest research has found that the onset of liver disease is related to the growth of endotoxins in the body by gram-negative bacteria.
Damage to the intestinal barrier function will lead to liver loss; probiotics can reduce acute liver damage caused by endotoxins.
　　Relief of liver inflammation by Lactobacillus casei Zhang 　　1.
Serum indicators 　　Lactobacillus casei Zhang can effectively reduce serum endotoxin, interleukin 1β (IL-1β), serum tumor necrosis factor ɑ (TNF-α) and nitric oxide (NO).
) Level to slow down the inflammation of the liver.
Compared with the conventional treatment drug dexamethasone, it has a similar relief effect.


　　2.
Histological evaluation
　　Lactobacillus casei Zhang can effectively improve liver histological evaluation damage, and the structure of liver lobules is well arranged.
Lactobacillus casei Zhang can also repair the structure of the intestine, relieve the damage of the villi structure and the necrosis of epithelial cells caused by liver damage, and relieve the swelling of the intestinal mucosa, significantly reducing the level of pathology.
　　3.
Determination of liver inflammation mediators 　　Lactobacillus casei Zhang can significantly reduce the activity of liver myeloperoxidase (MPO) and effectively regulate liver inflammation mediators.
　　4.
Western blot analysis　　Lactobacillus casei Zhang intervention significantly increased the expression of TLR2 and TLR9 to achieve anti-inflammatory effects.
　　5.
Intestinal flora analysis 　　Lactobacillus casei Zhang intervention significantly increased the content of beneficial bacteria such as Lactobacillus and Bifidobacterium, and reduced the content of pathogenic bacteria such as Clostridium and Bacteroides fragilis induced by liver inflammation.
However, in the intervention treatment of the conventional drug dexamethasone, it is impossible to observe the regulating effect on the intestinal flora.

　　Summary　　Lactobacillus casei Zhang can significantly improve acute liver injury and liver inflammation.
Serum endotoxin levels, related histological scores and MPO levels have all been significantly improved.
Compared with the conventional drug dexamethasone, Lactobacillus casei Zhang can also increase the content of beneficial bacteria and reduce the content of pathogenic bacteria to achieve regulation of intestinal bacteria.
Group and maintain the effect of intestinal flora balance.
　　The star strain, Lactobacillus casei Zhang 　　, was isolated from natural fermented mare milk in the Xilin Gol Prairie in Inner Mongolia in 2002.
It is the first lactic acid bacteria in China that has completed whole-genome sequencing.
Through scientific research, it has been found that Lactobacillus casei Zhang can regulate the intestinal flora, improve immunity, prevent upper respiratory tract infections in middle-aged and elderly people, and regulate the rejuvenation of intestinal flora.
As of January 2021, 16 related patents have been applied for Lactobacillus casei Zhang and 172 papers have been published.

Lactobacillus casei Zhang gene map article published in: Eur J Nutr (2016) 55:821–831

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