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Researchers at the State Key Laboratory of Carbonyl Synthesis and Selective Oxidation at the Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences have made new progress
in the field of inert phosphine bond activation.
Using transition metal palladium as catalyst and copper acetate as oxidant, they realized the arylation coupling reaction
of common triaryl phosphine compounds to oxabenzobornene under relatively mild conditions.
In this reaction, phosphine compounds show good group compatibility as both ligands and aryl donors, which provides a more effective way for the synthesis of diaryl substituted naphthalene, and at the same time, the new strategy of activating inert C-P bonds by cheap and readily available phosphine compounds opens a new window
for the potential application of phosphine compounds.
According to reports, phosphine compounds as ligands have a wide range of applications in transition metal catalysis, and can also be used as catalysts to catalyze a variety of widely used reactions, but the activation of phosphine carbide bonds based on their own is very rare
.
This is mainly due to the fact that the compounds have three unique physicochemical properties: inert C-P bonds have very high bond energy, phosphine is very easy to have strong coordination with various metal centers, and phosphine compounds are very easy to be oxidized into more stable strong polar compounds
.
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