Issue 24, 2015 - Advanced-Flow microchannel reactors enable seamless integration from laboratory to large-scale production

Corning and NiTech have successfully demonstrated an integrated continuous synthesis-separation production process
consisting of Corning's Advanced-Flow microchannel reactor and Ni Technology's continuous flow crystallizer, and Alconbury Weston Inc.
(AWL) continuous filtration equipment.
The integrated system provides a holistic approach
for continuous synthesis and downstream separation for pharmaceutical, fine and specialty chemicals.

Throughout this collaboration with Ni Technologies, Corning reactors have demonstrated their unique performance advantages
in continuous aspirin synthesis.
Corning reactors are not only very easy to use with continuous crystallization and continuous filtration, but they have achieved 100% conversion and 60g/h high purity aspirin products without further process optimization
.
Just a few days, Corning? Advanced-Flow, G1 reactor and Ni technology? The three-step integration of the DN15-Lite continuous crystallizer with AWL's continuous filtration unit yielded very good results
at Corning's AFR laboratory at its European Technical Center in France.
The small-scale test results of this continuous flow synthetic production system can easily be scaled up to the scale of a 1,000-ton industrial production plant without amplification effect
.

Corning reactors help fine, specialty chemical, and pharmaceutical manufacturers reduce costs
.
Corning? Compared with traditional stirred kettle reactors, the Advanced-Flow high-throughput microchannel reactor can increase the mixing capacity of multiphase systems by 100 times, improve the heat conduction performance by 1000 times, and realize the seamless connection
between laboratory and large-scale production.
(Qu Min)