Issue 20, 2013 - Northeast Agricultural University develops doramectin

Northeast Agricultural University develops doramectin

Recently, the Harbin Science and Technology Research Plan undertaken by Northeast Agricultural University "Construction and Dosage Form Processing and Application Research of New Agricultural Antibiotic Doramycin Metabolic Engineering Bacteria" passed the expert acceptance
.
The expert group determined that this achievement is the first in China and has reached the international advanced level
.

Taking the dolamyces avermitilis
NEAU1069 as the original strain, an excellent engineering bacterium metabolizing doramectin was obtained after the genetic engineering technology was used to knock out the abamectin-producing synthetic gene, which was identified as a new species of Streptomyces and had completely independent intellectual property rights
。 The output of the engineering bacteria in the 70T fermentation tank production line is stable at more than 1150μg/mL, which is 150 times higher than that of wild strains, and is different from the metabolic spectrum of wild strains industrialized by Pfizer in the United States, and the yield is relatively high, which is more suitable for the production of
industrial doramectin.

Doramectin metabolic engineering bacteria is the third generation of agricultural antibiotic products, has a high control effect on various mites and nematodes, and is better than the previous two generations of products in terms of toxicity, safety, stability and antioxidant resistance, especially for the control of diamondback moths, cotton bollworm and other pests
that seriously harm crops 。 The product does not produce cross-resistance with the currently commonly used pesticides, has low toxicity to non-target organisms, is safe for humans and other mammals, does not have serious residues in agricultural and sideline products, can replace highly toxic and high-residue chemical pesticides, meets the needs of pollution-free and residue-free "green" agricultural product production, and has broad market application prospects
.
(Gao Ping)