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Innate immune receptors detect
Helicobacter pylori
infection and trigger downstream signaling events that result in the production of cytokines and interferon-β. This chapter gives an overview of the receptors and their roles in responding to
H. pylori
infection and details the downstream signaling events. The tools that have been developed to study the innate immune response to
H. pylori
are also discussed. Understanding the immune response to
H. pylori
is critical to develop better treatments for
H. pylori-
induced disease states including gastric malignancies and cancer.