Immunologic Methods and Correlates of Protection
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Last Update: 2021-02-01
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Source: Internet
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Author: User
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Studies of natural rotavirus (RV) infection in children have shown that protection against subsequent RV disease occurs (
1
). Assessment of humoral immune responses has included study of the importance of circulating vs intestinal antibodies (Abs), serotype-specific vs group-specific Abs, and RV-specific immunoglobulins IgA, IgM, and IgG (
1
). Following natural RV infection, RV-specific IgM, followed by IgA and IgG, appear in serum and duodenal fluid or stool of young children (
2
). Protection against subsequent RV infection is predicted by the quantity of virus-specific IgA in the feces and serum (
3
,
4
). In addition, virus-specific antibody-secreting cells (ASC) of the IgA, IgM, and IgG isotypes have been detected in the blood of infants following RV infection (
5
), although correlation between the presence of ASCs and protection against subsequent disease has not been studied. Serum neutralizing antibodies (nAbs) occur after natural RV infection in children, and are serotype-specific (
4
,
6
). Overall, protection against subsequent RV infection is correlated with higher titers of nAb (
4
). Protection against infection has been correlated with homotypic nAb to the G1 serotype (
4
); however, other studies suggest that protection is not dependent on serotype-specific nAb (
7
).
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