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Click on the blue text above to follow us Researchers report that a highly virulent variant of HIV-1 has been circulating in the Netherlands for the past few decades
.
According to the new study, a group of more than 100 people infected with the virus subtype showed abnormally high viral loads, rapid decline in their CD4+ T cells, and increased infectivity of the virus subtype
.
While these findings suggest that this HIV lineage may have emerged at the turn of the millennium, widespread changes in its genome make it difficult to see the mechanisms underlying its increased virulence
.
Monitoring the virulence of HIV is an important task, as some 38 million people are currently infected with the virus
.
However, beyond recent studies of SARS-CoV-2 variants, there is a lack of understanding of the evolution of viral virulence beyond theoretical analysis
.
In the ongoing BEEHIVE project (Bridging HIV Epidemiology and Evolution in Europe), Chris Wymant and colleagues found that more than 100 people carry a distinct strain of HIV-1B subtype (known as the "VB variant") , which were characterized by high viral loads and nearly double the rate of CD4 cell decay compared with those infected with other HIV subtype B strains
.
According to Wymant et al.
, by the time these individuals are diagnosed, they can easily develop AIDS within 2 to 3 years
.
Further analysis of the VB variant revealed major changes throughout its genome, affecting nearly 300 amino acids, making it difficult to understand why this particular variant is so virulent
.
"The emergence of more virulent and contagious HIV is observed, not a public health crisis," writes Joel Wertheim in a Perspective, which discusses how and why the virus' virulence has evolved
.
"Let's not forget the overreaction brought about by the 'super AIDS' claim in 2005, when the discovery in New York of a fast-growing, multidrug-resistant HIV infection caused panic, but the infection was ultimately seen in only one person.
.
.
" Wertheim The article concludes with a discussion of how Wymant and colleagues' findings relate to the COVID-19 pandemic and the evolution of SARS-CoV-2 virulence
.
Welcome to the official public account of Science and click "Read the original text" below to access the English original text for this issue of Science to light up your reading!
.
According to the new study, a group of more than 100 people infected with the virus subtype showed abnormally high viral loads, rapid decline in their CD4+ T cells, and increased infectivity of the virus subtype
.
While these findings suggest that this HIV lineage may have emerged at the turn of the millennium, widespread changes in its genome make it difficult to see the mechanisms underlying its increased virulence
.
Monitoring the virulence of HIV is an important task, as some 38 million people are currently infected with the virus
.
However, beyond recent studies of SARS-CoV-2 variants, there is a lack of understanding of the evolution of viral virulence beyond theoretical analysis
.
In the ongoing BEEHIVE project (Bridging HIV Epidemiology and Evolution in Europe), Chris Wymant and colleagues found that more than 100 people carry a distinct strain of HIV-1B subtype (known as the "VB variant") , which were characterized by high viral loads and nearly double the rate of CD4 cell decay compared with those infected with other HIV subtype B strains
.
According to Wymant et al.
, by the time these individuals are diagnosed, they can easily develop AIDS within 2 to 3 years
.
Further analysis of the VB variant revealed major changes throughout its genome, affecting nearly 300 amino acids, making it difficult to understand why this particular variant is so virulent
.
"The emergence of more virulent and contagious HIV is observed, not a public health crisis," writes Joel Wertheim in a Perspective, which discusses how and why the virus' virulence has evolved
.
"Let's not forget the overreaction brought about by the 'super AIDS' claim in 2005, when the discovery in New York of a fast-growing, multidrug-resistant HIV infection caused panic, but the infection was ultimately seen in only one person.
.
.
" Wertheim The article concludes with a discussion of how Wymant and colleagues' findings relate to the COVID-19 pandemic and the evolution of SARS-CoV-2 virulence
.
Welcome to the official public account of Science and click "Read the original text" below to access the English original text for this issue of Science to light up your reading!
