Gut dysplasia affects early microbiota establishment, driving autism in mice

Wang Qian, Zhou Hongwei, e. : Intestinal dysplasia affects the establishment of early microflora and drives Brain Behavior and Immunity of autism in mice [IF:217] ① The autism spectrum disorder (ASD) mouse model was established by valproic acid (VPA) induction, and it was found that the VPA-exposed mice had congenital dysplasia of the intestine, accompanied by significant oxidative stress and inflammation; ② VPA group mice were born on day 0 There was no significant difference between the intestinal flora of the control group and the control group, but there were significant differences on the 7th and 21st days, and the abundance of Lactobacillus was significantly reduced; ③ Supplementation of superoxide dismutase (SOD) can alleviate the intestinal oxidative stress in early li. The congenitally hypoplastic gut is an early driving force for shaping autism-related gut microbiota and host neurodevelopment by enhancing oxidative stre. Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior06-14, doi: 11016. b. 2020006 【Editor's Comment】Autism Spectrum Disorder (ASD) is a widespread neurodevelopmental disord. Including abnormal behaviors such as social impairment, stereotypes and narrow interests, of which autism (also known as self-disorder) is the most serious o. Multiple studies have shown that gut microbiota can modulate gastrointestinal physiology, immune function, and even behavior through the gut-brain ax. Recently, Wang Qian, Zhou Hongwei, Li Zhuang and Muxuan Chen of Pearl River Hospital of Southern Medical University and their team published the latest research in Brain Behavior and Immunity, using valproic acid (VPA) to induce the establishment of an ASD mouse model, and found that VPA exposure can cause mice Congenital hypoplasia of the gut, characterized by excessive oxidative stress and inflammation, affects early microbiota colonizati. Supplementation with superoxide dismutase (SOD) early in life restores gut microbiota and improves ASD-related behaviors in autistic mi. In conclusion, this study provides new strategies for future intervention and treatment of A.   Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Netwo. Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te. Readers are only for reference and please Verify the relevant content yourse. Copyright Notice Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original auth. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat. Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden. , bio149 will be deleted within 12 hours after confirmati. Users are welcome to submit original articles to 86371366@. com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send.

Wang Qian, Zhou Hongwei, e.
: Intestinal dysplasia affects the establishment of early microflora and drives Brain Behavior and Immunity of autism in mice
① The autism spectrum disorder (ASD) mouse model was established by valproic acid (VPA) induction, and it was found that the VPA-exposed mice had congenital dysplasia of the intestine, accompanied by significant oxidative stress and inflammation; ② VPA group mice were born on day 0 There was no significant difference between the intestinal flora of the control group and the control group, but there were significant differences on the 7th and 21st days, and the abundance of Lactobacillus was significantly reduced; ③ Supplementation of superoxide dismutase (SOD) can alleviate the intestinal oxidative stress in early li.
The congenitally hypoplastic gut is an early driving force for shaping autism-related gut microbiota and host neurodevelopment by enhancing oxidative stre.
Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior06-14, doi: 11016.
b.
2020006 【Editor's Comment】Autism Spectrum Disorder (ASD) is a widespread neurodevelopmental disord.
Including abnormal behaviors such as social impairment, stereotypes and narrow interests, of which autism (also known as self-disorder) is the most serious o.
Multiple studies have shown that gut microbiota can modulate gastrointestinal physiology, immune function, and even behavior through the gut-brain ax.
Recently, Wang Qian, Zhou Hongwei, Li Zhuang and Muxuan Chen of Pearl River Hospital of Southern Medical University and their team published the latest research in Brain Behavior and Immunity, using valproic acid (VPA) to induce the establishment of an ASD mouse model, and found that VPA exposure can cause mice Congenital hypoplasia of the gut, characterized by excessive oxidative stress and inflammation, affects early microbiota colonizati.
Supplementation with superoxide dismutase (SOD) early in life restores gut microbiota and improves ASD-related behaviors in autistic mi.
In conclusion, this study provides new strategies for future intervention and treatment of A.

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Wang Qian, Zhou Hongwei, e.

: Intestinal dysplasia affects the establishment of early microflora and drives Brain Behavior and Immunity of autism in mice
① The autism spectrum disorder (ASD) mouse model was established by valproic acid (VPA) induction, and it was found that the VPA-exposed mice had congenital dysplasia of the intestine, accompanied by significant oxidative stress and inflammation; ② VPA group mice were born on day 0 There was no significant difference between the intestinal flora of the control group and the control group, but there were significant differences on the 7th and 21st days, and the abundance of Lactobacillus was significantly reduced; ③ Supplementation of superoxide dismutase (SOD) can alleviate the intestinal oxidative stress in early li.

The congenitally hypoplastic gut is an early driving force for shaping autism-related gut microbiota and host neurodevelopment by enhancing oxidative stre.

Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior06-14, doi: 11016.

b.

2020006 【Editor's Comment】Autism Spectrum Disorder (ASD) is a widespread neurodevelopmental disord.

Including abnormal behaviors such as social impairment, stereotypes and narrow interests, of which autism (also known as self-disorder) is the most serious o.

Multiple studies have shown that gut microbiota can modulate gastrointestinal physiology, immune function, and even behavior through the gut-brain ax.

Recently, Wang Qian, Zhou Hongwei, Li Zhuang and Muxuan Chen of Pearl River Hospital of Southern Medical University and their team published the latest research in Brain Behavior and Immunity, using valproic acid (VPA) to induce the establishment of an ASD mouse model, and found that VPA exposure can cause mice Congenital hypoplasia of the gut, characterized by excessive oxidative stress and inflammation, affects early microbiota colonizati.

Supplementation with superoxide dismutase (SOD) early in life restores gut microbiota and improves ASD-related behaviors in autistic mi.

In conclusion, this study provides new strategies for future intervention and treatment of A.

---

Wang Qian, Zhou Hongwei, e.

: Intestinal dysplasia affects the establishment of early microflora and drives the Brain Behavior and Immunity of autism in mice[IF:217]① The autism spectrum disorder (ASD) mouse model was established by valproic acid (VPA) induction, and it was found that the VPA-exposed mice had congenital dysplasia of the intestine, accompanied by significant oxidative stress and inflammation; ② The VPA group was small The intestinal flora of mice on day 0 of birth was not significantly different from that of the control group, but there were significant differences on days 7 and 21, and the abundance of Lactobacillus was significantly reduced; ③ Supplementation of superoxide dismutase (SOD) can alleviate life Early intestinal oxidative stress and inflammation, repair ASD-related gut microbiota, thereby improving autism behavior; ④ The congenitally hypoplastic gut shapes autism-related gut microbiota and host nerves by enhancing oxidative stress Early drivers of developme.

Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior06-14, doi: 11016.

b.

2020006 【Editor's Comment】Autism Spectrum Disorder (ASD) is a widespread neurodevelopmental disord.

Including abnormal behaviors such as social impairment, stereotypes and narrow interests, of which autism (also known as self-disorder) is the most serious o.

Multiple studies have shown that gut microbiota can modulate gastrointestinal physiology, immune function, and even behavior through the gut-brain ax.

Recently, Wang Qian, Zhou Hongwei, Li Zhuang and Muxuan Chen of Pearl River Hospital of Southern Medical University and their team published the latest research in Brain Behavior and Immunity, using valproic acid (VPA) to induce the establishment of an ASD mouse model, and found that VPA exposure can cause mice Congenital hypoplasia of the gut, characterized by excessive oxidative stress and inflammation, affects early microbiota colonizati.

Supplementation with superoxide dismutase (SOD) early in life restores gut microbiota and improves ASD-related behaviors in autistic mi.

In conclusion, this study provides new strategies for future intervention and treatment of A.

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