First discovery: Sheep fetus intestine has been planted active microbiome

Recently, the ruminant feed innovation team of the Feed Research Institute of the Chinese Academy of Agricultural Sciences revealed for the first time that there are active gut microbes before the birth of sheep fetuses, and determined the composition of the microbes and their active metabolites. This result is not only a breakthrough in the physiological research of ruminants, but also the first discovery in mammals. Related research results were published online in the internationally renowned medical journal "Gut" (Gut). According to Diao Qiyu, a researcher of the team, gastrointestinal microbes are the guarantee for ruminants such as cattle and sheep to digest forage, build an immune system, and promote growth and development. People have been exploring, when will microorganisms colonize the digestive tract? from where? What is the composition? It is generally believed that mammalian fetuses are sterile, and the microorganisms in the fetal intestines begin to colonize during delivery. However, the results of this study have given new insights. The team’s Ph. D. Bi Yanliang and others used multi-omics methods such as metagenomics, macrotranscriptomes, and metabolomes, and used lamb fetuses that are about to give birth at full-term as the test subjects. They collected cord blood and cecal chyme samples aseptically to detect their microorganisms and their metabolism. product. 　　The results confirmed that the lamb had colonized the active microbiome in the gut before birth. The study found that the microbiome in the intestinal tract of sheep fetus has the characteristics of low diversity and low biomass, which are mainly composed of bacteria from the Proteobacteria, Actinomycetes and Firmicutes. 　　Through metabolomics analysis, the researchers detected microbial-specific metabolites, such as short-chain fatty acids, deoxynojirimycin, mitomycin, and tobramycin, in the intestines of sheep fetuses, confirming that these microorganisms have metabolic activity. 　　This study provides direct evidence for the first time in the world, proving that there is an active microbiome in the gut of lambs before birth, and provides a basis for the colonization of fetal gut microbes from the uterus. It has important theoretical significance for the promotion of animal growth and body health by regulating the early host-microbe interaction, and it has great value for the early breeding of young animals. 　　The research was jointly funded by the National Key Research and Development Program, the National Natural Science Foundation of China, and the central public welfare basic scientific research business expenses. 　　Related paper information: http://dx. doi. org/10. 1136/gutjnl-2020-320951      Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com. The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself.      Copyright Notice    1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author. 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and clearly indicate the source and author. Media or individuals who do not want to be reprinted can contact us for infringement information that can provide sufficient evidence , Bio149 will be deleted within 12 hours after confirmation. 3. Users are welcome to post original articles to 86371366@qq. com, and publish them to the homepage after review. The copyright and liability belong to the sender.

　　Recently, the ruminant feed innovation team of the Feed Research Institute of the Chinese Academy of Agricultural Sciences revealed for the first time that there are active gut microbes before the birth of sheep fetuses, and determined the composition of the microbes and their active metabolites.
This result is not only a breakthrough in the physiological research of ruminants, but also the first discovery in mammals.
Related research results were published online in the internationally renowned medical journal "Gut" (Gut).
　　According to Diao Qiyu, a researcher of the team, gastrointestinal microbes are the guarantee for ruminants such as cattle and sheep to digest forage, build an immune system, and promote growth and development.
People have been exploring, when will microorganisms colonize the digestive tract? from where? What is the composition? It is generally believed that mammalian fetuses are sterile, and the microorganisms in the fetal intestines begin to colonize during delivery.
However, the results of this study have given new insights.
　　The team’s Ph.
D.
Bi Yanliang and others used multi-omics methods such as metagenomics, macrotranscriptomes, and metabolomes, and used lamb fetuses that are about to give birth at full-term as the test subjects.
They collected cord blood and cecal chyme samples aseptically to detect their microorganisms and their metabolism.
product.
　　The results confirmed that the lamb had colonized the active microbiome in the gut before birth.
The study found that the microbiome in the intestinal tract of sheep fetus has the characteristics of low diversity and low biomass, which are mainly composed of bacteria from the Proteobacteria, Actinomycetes and Firmicutes.
　　Through metabolomics analysis, the researchers detected microbial-specific metabolites, such as short-chain fatty acids, deoxynojirimycin, mitomycin, and tobramycin, in the intestines of sheep fetuses, confirming that these microorganisms have metabolic activity.
　　This study provides direct evidence for the first time in the world, proving that there is an active microbiome in the gut of lambs before birth, and provides a basis for the colonization of fetal gut microbes from the uterus.
It has important theoretical significance for the promotion of animal growth and body health by regulating the early host-microbe interaction, and it has great value for the early breeding of young animals.
　　The research was jointly funded by the National Key Research and Development Program, the National Natural Science Foundation of China, and the central public welfare basic scientific research business expenses.
　　Related paper information: http://dx.
doi.
org/10.
1136/gutjnl-2020-320951

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　　Recently, the ruminant feed innovation team of the Feed Research Institute of the Chinese Academy of Agricultural Sciences revealed for the first time that there are active gut microbes before the birth of sheep fetuses, and determined the composition of the microbes and their active metabolites.
This result is not only a breakthrough in the physiological research of ruminants, but also the first discovery in mammals.
Related research results were published online in the internationally renowned medical journal "Gut" (Gut).
　　According to Diao Qiyu, a researcher of the team, gastrointestinal microbes are the guarantee for ruminants such as cattle and sheep to digest forage, build an immune system, and promote growth and development.
People have been exploring, when will microorganisms colonize the digestive tract? from where? What is the composition? It is generally believed that mammalian fetuses are sterile, and the microorganisms in the fetal intestines begin to colonize during delivery.
However, the results of this study have given new insights.
　　The team’s Ph.
D.
Bi Yanliang and others used multi-omics methods such as metagenomics, macrotranscriptomes, and metabolomes, and used lamb fetuses that are about to give birth at full-term as the test subjects.
They collected cord blood and cecal chyme samples aseptically to detect their microorganisms and their metabolism.
product.
　　The results confirmed that the lamb had colonized the active microbiome in the gut before birth.
The study found that the microbiome in the intestinal tract of sheep fetus has the characteristics of low diversity and low biomass, which are mainly composed of bacteria from the Proteobacteria, Actinomycetes and Firmicutes.
　　Through metabolomics analysis, the researchers detected microbial-specific metabolites, such as short-chain fatty acids, deoxynojirimycin, mitomycin, and tobramycin, in the intestines of sheep fetuses, confirming that these microorganisms have metabolic activity.
　　This study provides direct evidence for the first time in the world, proving that there is an active microbiome in the gut of lambs before birth, and provides a basis for the colonization of fetal gut microbes from the uterus.
It has important theoretical significance for the promotion of animal growth and body health by regulating the early host-microbe interaction, and it has great value for the early breeding of young animals.
　　The research was jointly funded by the National Key Research and Development Program, the National Natural Science Foundation of China, and the central public welfare basic scientific research business expenses.
　　Related paper information: http://dx.
doi.
org/10.
1136/gutjnl-2020-320951

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