Emerging functional ingredients breast milk oligosaccharides have promising prospects

Human milk oligosaccharide (HMOS) is a complex mixed oligosaccharide naturally present in human milk.

Studies have found that breast milk oligosaccharides have more than 200 different types of structures and have strong individual differences

Research on the function of breast milk oligosaccharides continues to deepen

Breastmilk oligosaccharides improve gut microbiota in allergic infants In a study conducted by Nestlé Health Science, researchers added 2'-salicosyl lactose (2'-FL) and lactose-N- Neotetraose (LNnT), a mixture of two breast milk oligosaccharides

Breast milk oligosaccharides may affect cognition Abbott's PREOBE pilot study analyzed 82 breast milk samples from normal-weight, obese, and gestational diabetes patients and assessed the cognitive status of the babies of these mothers

Breast milk oligosaccharides may improve IBS symptoms The University of North Carolina recently released the results of a prospective open-label single-arm clinical trial of breast milk oligosaccharides improving irritable bowel syndrome (IBS)

The study showed a 54% reduction in the severity of IBS symptoms overall, and improvement in all three subtypes of IBS (constipation, diarrhea, and alternating IBS)

Breast milk oligosaccharides may be used to develop new prebiotics/probiotics relationship to develop new prebiotics/probiotics

Many companies have entered the field of breast milk oligosaccharides

The production technologies of breast milk oligosaccharides can be roughly divided into three categories: natural extraction, chemical synthesis and biosynthesis

On the supply side, at present, the top five producers of breast milk oligosaccharides in the world are DuPont, BASF, DSM, Jennewein and Frieslan Campina, all of which use traditional strains or common genetic engineering methods to synthesize breast milk oligosaccharides; while Nestle, Danone, Fast-moving food giants such as Yili have also entered this field through various forms of investment or cooperation

At the end of 2017, Professor Fang Xu, the founder and chief scientist of Henglu Biology, led the team to adopt biological enzymatic method and biological catalysis technology, using a new process with independent intellectual property rights, and using sucrose, glucose and lactose as substrates, the enzymatic method successfully synthesized two kinds of products.

The application of breast milk oligosaccharides continues to expand

From the perspective of market demand, the demand for breast milk oligosaccharides at home and abroad is increasing

Although breast milk oligosaccharide monomers like 2'-FL have now become a research hotspot, it is undeniable that due to the complexity of breast milk oligosaccharide composition and the dynamic variability during lactation, it is difficult to use a single breast milk low Glycan analogs to replace all breast milk oligosaccharides in breast milk

(Source: Gut Industry)

"China Food News" (November 08, 2021 06 edition)

(Editor in charge: Huang Guangshun)