Eating grapes increases gut microbiome diversity and lowers cholesterol

This article is the original of Translational Medicine. Please indicate the source. Introduction: Grapes are one of the most commonly eaten fruits, rich in polyphenols and fiber . However, there is limited information on the effects of eating grapes on the human gut microbiota and cholesterol metabolism . The new study aimed to assess the effects of consuming 46 grams of whole grape powder daily (equivalent to two servings of California table grapes) on the gut microbiome and cholesterol/bile acid metabolism in healthy adults . The study included a 4-week low-polyphenol diet followed by 4-week consumption of 46 grams of grape powder while continuing the low-polyphenol diet . The study found that consuming grape powder for 4 weeks significantly increased the diversity of the gut microbiome, increased beneficial bacteria in the gastrointestinal tract, and lowered blood cholesterol levels, helping to prevent cardiovascular disease . Researchers at the David Geffen School of Medicine at the University of California found evidence that eating grapes can increase the diversity of gut biomes and lower blood cholesterol levels . In their paper published in the journal Nutrients, the team describes experiments in which they fed volunteers grape powder for four weeks . The researchers published an article titled "Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study": Previous research has shown that consuming certain fruits, such as apples and grapes, can boost blood vessel health because they contain antioxidant polyphenols . Eating this fruit also lowers blood sugar and blood pressure levels . In some cases, polyphenol intake has been shown to reduce inflammation, which is a contributor to heart disease . Grapes not only contain a variety of phytochemicals, such as catechins, proanthocyanidins, anthocyanins, white anthocyanins, quercetin, kaempferol, stilbene, ellagic acid, hydroxycinnamic acid, etc. , but also a kind of fiber. Good source . In the new study, researchers looked at other possible health benefits of eating grapes . 　　To learn more about the possible positive health benefits, the team recruited 19 healthy adults . Inclusion criteria included being in good health, 18 to 55 years old, and accustomed to eating a low-fiber/low-polyphenol diet . Postmenopausal women and subjects taking any medications or dietary supplements that might interfere with polyphenol absorption were excluded . In addition, subjects who had taken antibiotics, laxatives, or probiotics within the past 3 months or were sensitive to grapes were excluded . The study was conducted by the Center for Human Nutrition at UCLA and is registered on the Clinical Trials website (clinicaltrials. gov) . This clinical protocol was approved by the UCLA Internal Review Board . The researchers conducted a two-phase intervention study with a 4-week standardization phase and a 4-week intervention phase . After 4 weeks of a low-polyphenol and low-fiber diet, each subject then continued on a low-fiber and low-polyphenol diet, but with the addition of grape powder . They ate 46 grams of the powder a day, the equivalent of two servings of grapes . Fasting blood and urine samples were collected and body composition was recorded at weeks 0 (start of standardization), 4 (before grape powder supplementation), and 8 weeks (end of grape powder supplementation) . Fecal samples were collected at weeks 4 and 8 . Effects of 4-week intake of grape powder on gut microbes 　　They found that after eating grape powder for four weeks (no gastrointestinal adverse effects were reported), all subjects had an increase in gut biodiversity . Studies have shown that increased gut biome diversity is often associated with a stronger immune system . It is worth noting that Akkermansia (Akermansia, also known as Akkobacter), known to have positive effects on glucose levels and lipid metabolism, is arguably a star bacterium since the development of gut microbes . This bacterium degrades mucin, Stimulates goblet cells to produce more mucin, which enhances protection of the gut barrier, which in turn helps prevent dysbiosis . This bacterium is also involved in the interaction between gut epithelial cells and the microbiota in diet-induced obesity. Interaction) levels of bacteria increased, and dietary strategies to increase beneficial bacteria in the gastrointestinal tract make great sense . Verrucomicrobia (Verrucomicrobia) showed an increasing trend (p = 0. 052) . Flavonifractor (involved in microbial catechin metabolism and affecting host immunity, its increase may be related to the content of catechins in grape powder) and Lachnospiraceae_UCG-010 increased content, while Bifidobacterium (Bifidobacterium) and Dialister (Bacteroides) content decreased . The researchers also found a 6. 1 percent drop in overall cholesterol levels and a 5. 9 percent drop in low-density lipoprotein (LDL) . They also found a 40. 9 percent drop in some steroid acids in bile -- which play a role in cholesterol metabolism . Elevated blood cholesterol levels are an established risk factor for cardiovascular disease . Consumption of grape powder had no significant effect on blood triglyceride levels and body composition . In conclusion, consumption of grape powder significantly improved gut microbiota and cholesterol/bile acid metabolism . Effects of 4-week grape powder intake on serum total cholesterol (A), total triglyceride (B), HDL cholesterol (C), and LDL cholesterol (D) 　　Fruits rich in polyphenols can have a prebiotic effect, leading to changes in the composition of the gut microbiota . An 8-week raisin diet improved liver function and atherosclerotic lesion formation in rabbits fed an atherogenic diet (0. 5% cholesterol) . A mouse study demonstrated that dietary supplementation of grape seed extract improved lipid profile by reducing hepatic cholesterol synthesis, promoting BA biosynthesis, reducing lipogenesis and intestinal BA transport, and increasing fecal BA and lipid excretion . 　　Taken together, the findings provide new information on the effects of grape intake on the gut microbiome, host cholesterol and bile acid metabolism . These data will aid the design of future studies to explore the health benefits of grape consumption . Reference: https://medicalxpress. com/news/2022-01-grapes-gut-biome-diversity-cholesterol. html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans . For health guidance, please go to a regular hospital for treatment .   Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Network . Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and text. Readers are only for reference and please Verify the relevant content yourself .   Copyright Notice 1. Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original author . 2. 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This article is the original of Translational Medicine.
Please indicate the source.


　　Introduction: Grapes are one of the most commonly eaten fruits, rich in polyphenols and fiber
.
However, there is limited information on the effects of eating grapes on the human gut microbiota and cholesterol metabolism
.
The new study aimed to assess the effects of consuming 46 grams of whole grape powder daily (equivalent to two servings of California table grapes) on the gut microbiome and cholesterol/bile acid metabolism in healthy adults
.
The study included a 4-week low-polyphenol diet followed by 4-week consumption of 46 grams of grape powder while continuing the low-polyphenol diet
.
The study found that consuming grape powder for 4 weeks significantly increased the diversity of the gut microbiome, increased beneficial bacteria in the gastrointestinal tract, and lowered blood cholesterol levels, helping to prevent cardiovascular disease
.


　　Researchers at the David Geffen School of Medicine at the University of California found evidence that eating grapes can increase the diversity of gut biomes and lower blood cholesterol levels
.
In their paper published in the journal Nutrients, the team describes experiments in which they fed volunteers grape powder for four weeks
.


　　The researchers published an article titled "Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study":

　　They found that after eating grape powder for four weeks (no gastrointestinal adverse effects were reported), all subjects had an increase in gut biodiversity
.
Studies have shown that increased gut biome diversity is often associated with a stronger immune system
.
It is worth noting that Akkermansia (Akermansia, also known as Akkobacter), known to have positive effects on glucose levels and lipid metabolism, is arguably a star bacterium since the development of gut microbes
.
This bacterium degrades mucin, Stimulates goblet cells to produce more mucin, which enhances protection of the gut barrier, which in turn helps prevent dysbiosis
.
This bacterium is also involved in the interaction between gut epithelial cells and the microbiota in diet-induced obesity.
Interaction) levels of bacteria increased, and dietary strategies to increase beneficial bacteria in the gastrointestinal tract make great sense
.
Verrucomicrobia (Verrucomicrobia) showed an increasing trend (p = 0.
052)
.
Flavonifractor (involved in microbial catechin metabolism and affecting host immunity, its increase may be related to the content of catechins in grape powder) and Lachnospiraceae_UCG-010 increased content, while Bifidobacterium (Bifidobacterium) and Dialister (Bacteroides) content decreased
.
The researchers also found a 6.
1 percent drop in overall cholesterol levels and a 5.
9 percent drop in low-density lipoprotein (LDL)
.
They also found a 40.
9 percent drop in some steroid acids in bile -- which play a role in cholesterol metabolism
.
Elevated blood cholesterol levels are an established risk factor for cardiovascular disease
.
Consumption of grape powder had no significant effect on blood triglyceride levels and body composition
.
In conclusion, consumption of grape powder significantly improved gut microbiota and cholesterol/bile acid metabolism
.


　　Fruits rich in polyphenols can have a prebiotic effect, leading to changes in the composition of the gut microbiota
.
An 8-week raisin diet improved liver function and atherosclerotic lesion formation in rabbits fed an atherogenic diet (0.
5% cholesterol)
.
A mouse study demonstrated that dietary supplementation of grape seed extract improved lipid profile by reducing hepatic cholesterol synthesis, promoting BA biosynthesis, reducing lipogenesis and intestinal BA transport, and increasing fecal BA and lipid excretion
.


　　Taken together, the findings provide new information on the effects of grape intake on the gut microbiome, host cholesterol and bile acid metabolism
.
These data will aid the design of future studies to explore the health benefits of grape consumption
.


Reference: https://medicalxpress.
com/news/2022-01-grapes-gut-biome-diversity-cholesterol.
html

Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.

---

This article is the original of Translational Medicine.
Please indicate the source.


　　Introduction: Grapes are one of the most commonly eaten fruits, rich in polyphenols and fiber
.
However, there is limited information on the effects of eating grapes on the human gut microbiota and cholesterol metabolism
.
The new study aimed to assess the effects of consuming 46 grams of whole grape powder daily (equivalent to two servings of California table grapes) on the gut microbiome and cholesterol/bile acid metabolism in healthy adults
.
The study included a 4-week low-polyphenol diet followed by 4-week consumption of 46 grams of grape powder while continuing the low-polyphenol diet
.
The study found that consuming grape powder for 4 weeks significantly increased the diversity of the gut microbiome, increased beneficial bacteria in the gastrointestinal tract, and lowered blood cholesterol levels, helping to prevent cardiovascular disease
.


　　Researchers at the David Geffen School of Medicine at the University of California found evidence that eating grapes can increase the diversity of gut biomes and lower blood cholesterol levels
.
In their paper published in the journal Nutrients, the team describes experiments in which they fed volunteers grape powder for four weeks
.


　　The researchers published an article titled "Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study":

　　They found that after eating grape powder for four weeks (no gastrointestinal adverse effects were reported), all subjects had an increase in gut biodiversity
.
Studies have shown that increased gut biome diversity is often associated with a stronger immune system
.
It is worth noting that Akkermansia (Akermansia, also known as Akkobacter), known to have positive effects on glucose levels and lipid metabolism, is arguably a star bacterium since the development of gut microbes
.
This bacterium degrades mucin, Stimulates goblet cells to produce more mucin, which enhances protection of the gut barrier, which in turn helps prevent dysbiosis
.
This bacterium is also involved in the interaction between gut epithelial cells and the microbiota in diet-induced obesity.
Interaction) levels of bacteria increased, and dietary strategies to increase beneficial bacteria in the gastrointestinal tract make great sense
.
Verrucomicrobia (Verrucomicrobia) showed an increasing trend (p = 0.
052)
.
Flavonifractor (involved in microbial catechin metabolism and affecting host immunity, its increase may be related to the content of catechins in grape powder) and Lachnospiraceae_UCG-010 increased content, while Bifidobacterium (Bifidobacterium) and Dialister (Bacteroides) content decreased
.
The researchers also found a 6.
1 percent drop in overall cholesterol levels and a 5.
9 percent drop in low-density lipoprotein (LDL)
.
They also found a 40.
9 percent drop in some steroid acids in bile -- which play a role in cholesterol metabolism
.
Elevated blood cholesterol levels are an established risk factor for cardiovascular disease
.
Consumption of grape powder had no significant effect on blood triglyceride levels and body composition
.
In conclusion, consumption of grape powder significantly improved gut microbiota and cholesterol/bile acid metabolism
.


　　Fruits rich in polyphenols can have a prebiotic effect, leading to changes in the composition of the gut microbiota
.
An 8-week raisin diet improved liver function and atherosclerotic lesion formation in rabbits fed an atherogenic diet (0.
5% cholesterol)
.
A mouse study demonstrated that dietary supplementation of grape seed extract improved lipid profile by reducing hepatic cholesterol synthesis, promoting BA biosynthesis, reducing lipogenesis and intestinal BA transport, and increasing fecal BA and lipid excretion
.


　　Taken together, the findings provide new information on the effects of grape intake on the gut microbiome, host cholesterol and bile acid metabolism
.
These data will aid the design of future studies to explore the health benefits of grape consumption
.


Reference: https://medicalxpress.
com/news/2022-01-grapes-gut-biome-diversity-cholesterol.
html

Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.

---

https://medicalxpress.
com/news/2022-01-grapes-gut-biome-diversity-cholesterol.
html

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