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    Home > Biochemistry News > Microbiology News > Domestic team: Bacillus coagulans combined with chitosan oligosaccharide may improve colitis in mice

    Domestic team: Bacillus coagulans combined with chitosan oligosaccharide may improve colitis in mice

    • Last Update: 2022-08-19
    • Source: Internet
    • Author: User
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    Microbiology spectrum
    [IF:043]
    ① To evaluate the therapeutic effect of Bacillus coagulans FCYS01 spores in the presence or absence of chitosan oligosaccharides (COSs) on DSS-induced ulcerative colitis (UC) in mice;② Supplementation of FCYS01, COSs or the synergy of both can reduce tissue damage and regulate cytokines and C-reactive protein levels, increase the expression of tight junction proteins and mucins, and promote intestinal barrier recovery and effectively relieve UC;③ Supplementation with FCYS01 and COSs can also regulate the composition of intestinal flora, increasing the number of short chains such as Akkermansia and Ruminococcus The abundance of fatty acid-producing bacteria increased the level of short-chain fatty acids;④ The combination of FCYS01 spores and COSs could significantly relieve DSS-induced UC, and the therapeutic effect was better than that of the two alon.
    Bacillus coagulans in Combination with Chitooligosaccharides Regulates Gut Microbiota and Ameliorates the DSS-Induced Colitis in Mice07-28, doi:11128/spectru.
    00641-22The occurrence of its disease is the result of the combined action of immune factors, genetic factors, environmental factors and infectious factor.
    Recent studies have found that the combined use of probiotics and prebiotics can effectively relieve inflammation in U.
    Recently, Peng Nan and his team from Chengdu University/Huazhong Agricultural University published a new study on the Microbiology spectrum, using DSS to induce a colitis model in mic.
    And the treatment effect is better than the two used alon.
    In conclusion, this study provides a new idea for future combined use of probiotics and prebiotics to intervene in coliti.
    (@jiuqingchen)

     
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