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Human caliciviruses (HuCVs) and astroviruses are single-stranded RNA viruses that cause acute gastroenteritis in humans. HuCVs include several prototypes of small, round-structured viruses (SRSVs) as well as morphologically typical caliciviruses. Recent genetic characterization of HuCVs has divided them into three genogroups: Norwalk virus (NV), Snow Mountain agent (SMA), and Sapporo (Sapp) viruses (
1
–3 ). Astroviruses include at least seven antigenic types (
4
). Complete genomic sequences of astrovirus types 1 and 2 and partial sequences of other strains have been reported (
5
–7 ). In both families, differences in antigenic types appear to correspond to differences in genetic groups.