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Dendritic Cell Generation from Highly Purified CD14+Monocytes

 Last Update: 2021-02-15
 Source: Internet
 Author: User

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2 5 hexanedione

neural progenitor cells

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Dendritic cells (DC) play a pivotal role in the function of the immune system, for they are the primary antigen-presenting cells (APC) in the activation of naive T-lymphocyte responses (
1
). Recent studies have uncovered complexity in the DC lineage with several subsets, functions, and maturational stages. Although it is generally accepted that human DC derive from hematopoietic progenitor cells (
2
-
9
), it is not clear at present whether DC cells and their precursors represent a separate hematopoietic lineage or whether DC should be seen as specialized macrophages with particular morphological, molecular, and functional features. Several lines of evidence point to DC and monocytes/ macrophages being offspring of the same CD34
+
hematopoietic progenitor cell (
3
-5 ,12 -
14
, and reviewed in ([
10
,11 ].) DC committed precursor cells have also been identified in peripheral blood (
15
-
18
).

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