Damage to the intestines and increase the risk of colitis! The harm of a high-sugar diet is really great

is a more common disease and a complex and recurrent disease that can cause persistent diarrhea, abdominal pain and rectal bleeding. The number of U.S. adults with inflammatory bowel disease (IBD) rose from 2 million in 1999 to 3 million in 2015, according to the U.S. Centers for Disease Control and Prevention. What's more, colitis begins to appear in children who have never had the disease before.Because of the high prevalence of the disease in Western countries, researchers have identified a Western diet rich in fat, sugar and animal protein as a possible risk factor. Although a high-fat diet has been found to trigger IBD, the role of sugar is more controversial.On October 28th researchers at the University of Texas Southwestern Medical Center found that sugar was the main "suspect" and that monosaccharose in the diet altered the microbial ecology of the gut and caused colitis in mice. The results were published in the journal Science-Translational Medicine.The researchers fed the mice a 10 percent aqueous solution containing a variety of dietary sugars (glucose, fructose and sucrose). It was found that in mice genetically susceptible to colitis or in mice with chemically induced models of colitis, more severe symptoms were found if sugar solution was fed first.

, the researchers used gene sequencing techniques to analyze the type and prevalence of bacteria found in the large intestines of mice before and after receiving the sugar solution. The results showed that after seven days of giving the sugar solution, there was a significant change in the number of microorganisms in the intestines of mice that consumed sucrose, fructose, and especially glucose. The number of bacteria that produce mucus-degrading enzymes, such as Ackermann's, has increased, while other types of bacteria(such as Lactobacillus), which are considered "good bacteria" and are "residents" in the gut, have become smaller.In addition, the researchers found evidence of thinning of the mucus layer that protects the inner wall of the large intestine, as well as other signs of bacterial infection. The researchers explained: "The mucus layer protects intestinal mucosa tissue from intestinal bacteria, while mice treated with glucose have higher levels of bacteria that degrade mucus, indicating a potential danger to the intestinal mucus barrier."in mice treated with glucose, gut bacteria are very close to the upper cortical layer of the large intestine, and breaking through the cortical barrier is the main cause of intestinal inflammation.The researchers then fed sugar-fed mouse droppings to other sterile mice, which developed more severe colitis. This suggests that glucose-induced susceptivity to colitis can be transmitted with the destructive gut microbiota of diseased animals.In addition, the study found that although glucose played the biggest role, sucrose, fructose and glucose, all three simple sugars, profoundly changed the composition of the gut bacteriosta. Previous studies have shown that both human and mouse gut bacteria can change with changes in diet, which is a clear reminder of the need to pay attention to our diet. (Biological Exploration):1. Dietary simple sugars alter microbialecology in the gut and promote colitis in mice[2].