Science Sub-Journal: Damage to the intestines increases the risk of colitis! The harm of a high-sugar diet is really great

Colitis is a relatively common disease, but also a complex and prone to recurrent diseases, which can cause persistent diarrhea, abdominal pain and rectal bleeding.
the number of U.S. adults with inflammatory bowel disease (IBD) has risen from 2 million in 1999 to 3 million in 2015, according to the U.S. Centers for Disease Control and Prevention.
more importantly, colitis begins to appear in children who have never had the disease before.
because of the high prevalence of the disease in Western countries, researchers have identified a Western diet rich in fat, sugar and animal protein as a possible risk factor.
the role of sugar is more controversial, although high-fat diets have been found to trigger IBD.
October 28, researchers at the University of Texas Southwestern Medical Center found that sugar is the main "suspect" and that monosaccharose in the diet alters the microbial ecology of the gut and causes colitis in mice.
results were published in the journal Science-Translational Medicine.
DOI:10.1126/scitranslmed.aay6218 researchers fed mice a 10% water solution containing a variety of dietary sugars (glucose, fructose and sucrose).
found that for mice genetically susceptible to colitis or mice with chemically induced models of colitis, more severe symptoms could occur if sugar solutions were fed first.
, the researchers used gene sequencing techniques to analyze the type and prevalence of bacteria found in the large intestines of mice before and after receiving the sugar solution.
results showed a significant change in the number of microbes in the guts of mice that consumed sucrose, fructose, and especially glucose after seven days of giving the sugar solution.
the number of bacteria that produce mucus-degrading enzymes, such as Ackman's, has increased, while fewer other types of bacteria, such as Lactobacillus, which are considered "good bacteria" and are "residents" in the gut.
, the researchers found evidence of thinning of the mucus layer that protects the inner wall of the large intestine, as well as other signs of bacterial infection.
researchers explained: "The mucus layer protects the mucous tissue from the intestinal bacteria, while the high levels of bacteria degrading mucus in mice treated with glucose indicate a potential danger to the intestinal mucus barrier."
"Due to the corrosion of the mucus layer, in mice treated with glucose, the gut bacteria were very close to the upper cortical layer of the large intestine, and breaking through the cortical barrier was the main cause of intestinal inflammation.
, the researchers fed sugar-fed mouse droppings to other sterile mice and found that they developed more severe colitis.
suggests that glucose-induced susceptivity to colitis can spread with destructive gut microbiota in diseased animals.
addition, the study found that, despite the greatest effects of glucose, sucrose, fructose and glucose, all three simple sugars, profoundly changed the composition of the gut microbiota.
previous studies have shown that the gut bacteria in both humans and mice can change with changes in diet, which is a clear reminder of the need to pay attention to our diet.
References: . . . Dietary simple sugars alter microbialecology in the gut and promote colitis in mice.