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According to a study published in the Journal of Clinical Microbiology on April 26, changes in the SARS-CoV-2 genome-including some of the genomic changes found in currently popular variants-may be It has a negative impact on reverse transcription (RT) PCR detection of viruses
The author said that this discovery did not cause a full panic
The primers used for RT-PCR analysis were developed early in the pandemic when the SARS-CoV-2 virus was first sequenced
The molecular diagnostic laboratory at Washington University's Barnes-Jewish Hospital has been using Roche's cobas SARS-CoV-2 test to process patient samples
"If you have a high test value on one gene, you also have a high value on another gene, and vice versa," said Bijal Parikh, co-author of the University of Washington clinical pathologist and medical director of the Molecular Diagnostic Laboratory.
Despite this strange result, the test still correctly identified sars-cov -2 positive samples based on the ORF1ab signal
Unfortunately, they were unable to confirm this hypothesis because the primer and probe sequences of the experiment were not disclosed
Another study published in the Journal of Clinical Microbiology in September reported similar results.
Crawford said: "We are still studying the most conserved and least conserved regions of the virus
Chantal Vogels, a virologist at the Yale School of Public Health, was not involved in this new work.
PCR detection captures an evolving virus
The U.
"From the very beginning, we have been watching all the different variants closely," said Palani Kumaresan, head of R&D for Roche Diagnostic Solutions
A media representative from the Centers for Disease Control and Prevention (CDC) told The Scientist via e-mail that the center regularly monitors the COVID-19 diagnostic team and the primers and probes for multiple detection of influenza and COVID-19
Vogels said: "As long as the virus continues to change-this is a natural thing-you need continuous monitoring
S.
