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CMI (IF=22) Chen Hualan/Li Chengjun, Chinese Academy of Agricultural Sciences, discovered a new regulatory mechanism for the replication cycle of influenza A virus

 Last Update: 2022-09-15
 Source: Internet
 Author: User

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As a major component of the viral ribonucleoprotein (vRNP) complex in influenza A virus (IAV), the nuclear protein (NP) interacts with the isomers of the input protein α family members, leading to itself and the vRNP complex into the nucleus, a key process

On September 2, 2022, Chen Hualan and Li Chengjun of the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences jointly published a newsletter at Cellular & Molecular Immunology (IF=22) entitled "Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is.

In this study, it was found that a subtype of the Bcl 10-interaction protein with a CARD (BinCARD) is used by IAV for efficient viral replication

Influenza A virus (IAV) belongs to the family Orthogonal viruses

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