[Cell] Stanford researchers have built the most complex and complete synthetic microbiome

This article is the original of translational medicine network, please indicate the source when reprinting

Author: Sophia

Key studies over the past decade have shown that the gut microbiome, a collection of hundreds of bacterial species living in the human digestive system, influences neurodevelopment, response to cancer immunotherapy, and other aspects of

Researchers at Stanford University built the most complex and complete synthetic microbiome, creating a community of more than 100 species of bacteria that were successfully transplanted into mice

Many of the key microbiome studies are done using fecal transplantation, which introduces an entire natural microbiome from one organism to another

Michael Fischbach said, "If it weren't for its ability to manipulate complex biological systems in segments, we wouldn't know so much

https://doi.

Build the Ark

 01 

Each cell in the microbiome occupies a specific functional niche, performing reactions

The researchers decided to build their colonies with the most popular bacteria and turned to the Human Microbiome Project (HMP), an initiative of the National Institutes of Health that aims to sequence

The researchers selected more than 100 strains of bacteria that are present in at least 20 percent of individuals with

While there is satisfaction that these strains can coexist in the lab, the real test is whether their new colonies will take root

External intrusion

 02 

To make this human community more complete, the researchers hope to ensure that all important microbiome functions will be performed

Notably, hCom1 also has its own properties, with only about 10% of the cells in the final community coming from fecal transplantation

The researchers found more than 20 new bacteria

The ultimate challenge

 03 

To demonstrate the utility of its synthetic microbiome, the team took mice colonized with hCom2, challenging

Previous research has shown that a healthy natural microbiome brings protection, but Fischbach and colleagues can go a step further
by iteratively eliminating or modifying certain strains to determine which strains are particularly endowed with protection.

They identified several key bacteria and plan to conduct further studies to narrow down to the most critical species
.

Fischbach believes that hCom2 or its future versions will enable similar reductionist studies to reveal bacterial formulations involved in other fields, such as immunotherapy responses
.

Fischbach said: "We have established this alliance
for the wider research community.

It is hoped that as much as possible will be handed over to other scientists to make an impact on
the field.

”

This approach to building a microbiome from scratch will enable microbiome-based engineering therapies in the future
.

The scientists' goal is to build a population of organisms that could one day be transplanted into humans to treat or prevent a variety of diseases
.

Resources:

https://phys.
org/news/2022-09-complex-synthetic-microbiome.
html

https://doi.
org/10.
1016/j.
cell.
2022.
08.
003

Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for
treatment options.

For health guidance, please visit a regular hospital
.

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