Cell Heavy: Use probiotics to treat brain diseases and improve social behavior!

More and more evidence shows that the gut microbiome can help regulate brain function through the "gut-brain axis". Therefore, when searching for the causes and treatments of neurological diseases, one should not just confine themselves to the brain. In a new study published in "Cell" on March 11, Beijing time, a research team led by Baylor College of Medicine found that gut microbes can also cause certain symptoms related to complex neurological diseases. Therefore, to untie the bell, it is necessary to tie the bell "human". Microbial-based therapy, that is, the use of intestinal bacteria can treat specific brain diseases and improve social behavior. Many traditional views believe that the core symptoms of neurological diseases are caused by genetic variations that affect brain development and function. However, the gut microbiome, another important source of variation, can also influence the host’s specific behaviors through the "gut-brain axis". Therefore, revealing the genetic variation of the host, the gut microbiome, and their interactions with complex behaviors is crucial. Researchers found that in mouse models of neurodevelopmental disorders, ADHD is controlled by the host's genetic genes; while social behavior deficits are mediated by the gut microbiome. Unexpectedly, when the researchers intervened in mice with a specific microorganism that promotes the production of biopterin family compounds in the intestine, it could improve the animals' social deficits, but they could not improve their ADHD behavior. The corresponding author of the study, Dr. Mauro Costa-Mattioli, Director of the Center for Memory and Brain Research at Baylor College of Medicine, said: “We are both host genes and carriers of microbial genes. Although most research focuses on host genes, the gut microbiome It is also an important source of genetic information. " 　　In this study, the team provided a different perspective on neurological diseases and their treatments. In this type of disease, human genes and microbial genes interact and cause the disease. Researchers emphasize that effective treatment may need to target the brain and intestines at the same time to adequately resolve all symptoms. In addition, the study also explored the possibility that complex diseases such as cancer, diabetes, viral infections or other neurological diseases involve the microbiome. 　　It is extremely difficult to study these complex interactions in the human body. Therefore, the team studied a mouse model with neurodevelopmental disorders, which lacks two copies of the Cntnap2 gene (Cntnap2–/– mice). They exhibit social deficits and hyperactive ADHD behaviors similar to those observed in patients with autism spectrum disorder (ASD). In addition, compared with mice without modified genes, these genetically-deficient mice, like many people with autism, have changes in the composition of their intestinal flora. 　　Sean Dooling, the first author of the study and a PhD student in molecular and human genetics in Costa Mattioli’s laboratory, said: “We can distinguish between the microbiome and the impact of animal genetic mutations on behavioral changes. This shows that in the study of health and disease, the gut microbiome It should not be ignored, it is also an important variable. ” 　　Subsequently, the researchers further studied the mechanism of the influence of the gut microbiome on animal social deficits. Based on their previous work, the researchers used Lactobacillus reuteri to treat mice. 　　Lactobacillus reuteri (L. reuteri) occurs almost naturally in the intestines of all vertebrates and mammals. In 2003, the Ministry of Health of my country has approved Lactobacillus reuteri as a microbial strain for human health care products, and this bacterium is an internationally recognized new type of probiotic lactic acid bacteria, which has high theoretical research and production application value. 　　The researchers found that Lactobacillus reuteri can also restore the social behavior of mice, but it cannot correct the overactive behavior of Cntnap2-/- mice. 　　However, when the researchers injected the metabolites of the tetrahydrobiopterin synthesis pathway into the socially disabled mice, the metabolites of Lactobacillus reuteri in the host intestine also increased; and after the metabolites were used to replace the bacteria, the mice The social deficiencies have also been improved. 　　In other words, the study provides at least two potential methods, namely, the use of intestinal bacteria or metabolites induced by bacteria to regulate brain function. 　　Can this research bring new breakthroughs in the treatment of neurological diseases? Although it is too early to draw conclusions, the researchers are hopeful about the transformative significance of their research. 　　The study emphasized the use of probiotics or bacteria to stimulate safe and effective treatments against the gut microbiome. The researchers said that with a better understanding of these bacteria, it is expected that their power will be used more accurately and effectively to help treat complex human brain diseases and even more diseases. 　　Costa-Mattioli said: "Although scientific progress has brought the hope of genetic manipulation, there are still many difficulties in regulating human genes to treat diseases, but regulating our gut microbiome is an interesting non-invasive alternative. I never thought that the microbes in the gut could regulate behavior and brain function. Now it seems that microbial-based strategies may really be a feasible treatment for neurological dysfunction. The idea is crazy but exciting. In fact. , Lactobacillus reuteri is currently undergoing clinical trials on children with autism in Italy, and we plan to start our own clinical trials soon. " Link to the paper: https://doi. org/10. 1016/j. cell. 2021. 02. 009      Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com. The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself.      Copyright Notice    1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author. 2. 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　　More and more evidence shows that the gut microbiome can help regulate brain function through the "gut-brain axis".
Therefore, when searching for the causes and treatments of neurological diseases, one should not just confine themselves to the brain.
　　In a new study published in "Cell" on March 11, Beijing time, a research team led by Baylor College of Medicine found that gut microbes can also cause certain symptoms related to complex neurological diseases.
Therefore, to untie the bell, it is necessary to tie the bell "human".
Microbial-based therapy, that is, the use of intestinal bacteria can treat specific brain diseases and improve social behavior.
　　Many traditional views believe that the core symptoms of neurological diseases are caused by genetic variations that affect brain development and function.
However, the gut microbiome, another important source of variation, can also influence the host’s specific behaviors through the "gut-brain axis".
Therefore, revealing the genetic variation of the host, the gut microbiome, and their interactions with complex behaviors is crucial.
　　Researchers found that in mouse models of neurodevelopmental disorders, ADHD is controlled by the host's genetic genes; while social behavior deficits are mediated by the gut microbiome.
　　Unexpectedly, when the researchers intervened in mice with a specific microorganism that promotes the production of biopterin family compounds in the intestine, it could improve the animals' social deficits, but they could not improve their ADHD behavior.

　　The corresponding author of the study, Dr.
Mauro Costa-Mattioli, Director of the Center for Memory and Brain Research at Baylor College of Medicine, said: “We are both host genes and carriers of microbial genes.
Although most research focuses on host genes, the gut microbiome It is also an important source of genetic information.
" 　　In this study, the team provided a different perspective on neurological diseases and their treatments.
In this type of disease, human genes and microbial genes interact and cause the disease.
Researchers emphasize that effective treatment may need to target the brain and intestines at the same time to adequately resolve all symptoms.
In addition, the study also explored the possibility that complex diseases such as cancer, diabetes, viral infections or other neurological diseases involve the microbiome.
　　It is extremely difficult to study these complex interactions in the human body.
Therefore, the team studied a mouse model with neurodevelopmental disorders, which lacks two copies of the Cntnap2 gene (Cntnap2–/– mice).
They exhibit social deficits and hyperactive ADHD behaviors similar to those observed in patients with autism spectrum disorder (ASD).
In addition, compared with mice without modified genes, these genetically-deficient mice, like many people with autism, have changes in the composition of their intestinal flora.
　　Sean Dooling, the first author of the study and a PhD student in molecular and human genetics in Costa Mattioli’s laboratory, said: “We can distinguish between the microbiome and the impact of animal genetic mutations on behavioral changes.
This shows that in the study of health and disease, the gut microbiome It should not be ignored, it is also an important variable.
” 　　Subsequently, the researchers further studied the mechanism of the influence of the gut microbiome on animal social deficits.
Based on their previous work, the researchers used Lactobacillus reuteri to treat mice.
　　Lactobacillus reuteri (L.
reuteri) occurs almost naturally in the intestines of all vertebrates and mammals.
In 2003, the Ministry of Health of my country has approved Lactobacillus reuteri as a microbial strain for human health care products, and this bacterium is an internationally recognized new type of probiotic lactic acid bacteria, which has high theoretical research and production application value. 　　The researchers found that Lactobacillus reuteri can also restore the social behavior of mice, but it cannot correct the overactive behavior of Cntnap2-/- mice.
　　However, when the researchers injected the metabolites of the tetrahydrobiopterin synthesis pathway into the socially disabled mice, the metabolites of Lactobacillus reuteri in the host intestine also increased; and after the metabolites were used to replace the bacteria, the mice The social deficiencies have also been improved.

　　In other words, the study provides at least two potential methods, namely, the use of intestinal bacteria or metabolites induced by bacteria to regulate brain function.
　　Can this research bring new breakthroughs in the treatment of neurological diseases? Although it is too early to draw conclusions, the researchers are hopeful about the transformative significance of their research.
　　The study emphasized the use of probiotics or bacteria to stimulate safe and effective treatments against the gut microbiome.
The researchers said that with a better understanding of these bacteria, it is expected that their power will be used more accurately and effectively to help treat complex human brain diseases and even more diseases.
　　Costa-Mattioli said: "Although scientific progress has brought the hope of genetic manipulation, there are still many difficulties in regulating human genes to treat diseases, but regulating our gut microbiome is an interesting non-invasive alternative.
I never thought that the microbes in the gut could regulate behavior and brain function.
Now it seems that microbial-based strategies may really be a feasible treatment for neurological dysfunction.
The idea is crazy but exciting.
In fact.
, Lactobacillus reuteri is currently undergoing clinical trials on children with autism in Italy, and we plan to start our own clinical trials soon.
" Link to the paper: https://doi.
org/10.
1016/j.
cell.
2021.
02.
009

---

　　More and more evidence shows that the gut microbiome can help regulate brain function through the "gut-brain axis".
Therefore, when searching for the causes and treatments of neurological diseases, one should not just confine themselves to the brain.
　　In a new study published in "Cell" on March 11, Beijing time, a research team led by Baylor College of Medicine found that gut microbes can also cause certain symptoms related to complex neurological diseases.
Therefore, to untie the bell, it is necessary to tie the bell "human".
Microbial-based therapy, that is, the use of intestinal bacteria can treat specific brain diseases and improve social behavior.
　　Many traditional views believe that the core symptoms of neurological diseases are caused by genetic variations that affect brain development and function.
However, the gut microbiome, another important source of variation, can also influence the host’s specific behaviors through the "gut-brain axis".
Therefore, revealing the genetic variation of the host, the gut microbiome, and their interactions with complex behaviors is crucial.
　　Researchers found that in mouse models of neurodevelopmental disorders, ADHD is controlled by the host's genetic genes; while social behavior deficits are mediated by the gut microbiome.
　　Unexpectedly, when the researchers intervened in mice with a specific microorganism that promotes the production of biopterin family compounds in the intestine, it could improve the animals' social deficits, but they could not improve their ADHD behavior.

　　The corresponding author of the study, Dr.
Mauro Costa-Mattioli, Director of the Center for Memory and Brain Research at Baylor College of Medicine, said: “We are both host genes and carriers of microbial genes.
Although most research focuses on host genes, the gut microbiome It is also an important source of genetic information.
" 　　In this study, the team provided a different perspective on neurological diseases and their treatments.
In this type of disease, human genes and microbial genes interact and cause the disease.
Researchers emphasize that effective treatment may need to target the brain and intestines at the same time to adequately resolve all symptoms.
In addition, the study also explored the possibility that complex diseases such as cancer, diabetes, viral infections or other neurological diseases involve the microbiome.
　　It is extremely difficult to study these complex interactions in the human body.
Therefore, the team studied a mouse model with neurodevelopmental disorders, which lacks two copies of the Cntnap2 gene (Cntnap2–/– mice).
They exhibit social deficits and hyperactive ADHD behaviors similar to those observed in patients with autism spectrum disorder (ASD).
In addition, compared with mice without modified genes, these genetically-deficient mice, like many people with autism, have changes in the composition of their intestinal flora.
　　Sean Dooling, the first author of the study and a PhD student in molecular and human genetics in Costa Mattioli’s laboratory, said: “We can distinguish between the microbiome and the impact of animal genetic mutations on behavioral changes.
This shows that in the study of health and disease, the gut microbiome It should not be ignored, it is also an important variable.
” 　　Subsequently, the researchers further studied the mechanism of the influence of the gut microbiome on animal social deficits.
Based on their previous work, the researchers used Lactobacillus reuteri to treat mice.
　　Lactobacillus reuteri (L.
reuteri) occurs almost naturally in the intestines of all vertebrates and mammals.
In 2003, the Ministry of Health of my country has approved Lactobacillus reuteri as a microbial strain for human health care products, and this bacterium is an internationally recognized new type of probiotic lactic acid bacteria, which has high theoretical research and production application value. 　　The researchers found that Lactobacillus reuteri can also restore the social behavior of mice, but it cannot correct the overactive behavior of Cntnap2-/- mice.
　　However, when the researchers injected the metabolites of the tetrahydrobiopterin synthesis pathway into the socially disabled mice, the metabolites of Lactobacillus reuteri in the host intestine also increased; and after the metabolites were used to replace the bacteria, the mice The social deficiencies have also been improved.

　　In other words, the study provides at least two potential methods, namely, the use of intestinal bacteria or metabolites induced by bacteria to regulate brain function.
　　Can this research bring new breakthroughs in the treatment of neurological diseases? Although it is too early to draw conclusions, the researchers are hopeful about the transformative significance of their research.
　　The study emphasized the use of probiotics or bacteria to stimulate safe and effective treatments against the gut microbiome.
The researchers said that with a better understanding of these bacteria, it is expected that their power will be used more accurately and effectively to help treat complex human brain diseases and even more diseases.
　　Costa-Mattioli said: "Although scientific progress has brought the hope of genetic manipulation, there are still many difficulties in regulating human genes to treat diseases, but regulating our gut microbiome is an interesting non-invasive alternative.
I never thought that the microbes in the gut could regulate behavior and brain function.
Now it seems that microbial-based strategies may really be a feasible treatment for neurological dysfunction.
The idea is crazy but exciting.
In fact.
, Lactobacillus reuteri is currently undergoing clinical trials on children with autism in Italy, and we plan to start our own clinical trials soon.
" Link to the paper: https://doi.
org/10.
1016/j.
cell.
2021.
02.
009

---

More and more evidence shows that the gut microbiome can help regulate brain function through the "gut-brain axis".
Therefore, when searching for the causes and treatments of neurological diseases, one should not just confine themselves to the brain.
In a new study published in "Cell" on March 11, Beijing time, a research team led by Baylor College of Medicine found that gut microbes can also cause certain symptoms related to complex neurological diseases.
Therefore, to untie the bell, it is necessary to tie the bell "human".
Microbial-based therapy, that is, using intestinal bacteria can treat specific brain diseases and improve social behavior.

Many traditional views believe that the core symptoms of neurological diseases are caused by genetic variations that affect brain development and function.
However, the gut microbiome, another important source of variation, can also influence the host’s specific behaviors through the "gut-brain axis".
Therefore, revealing the genetic variation of the host, the gut microbiome, and their interactions with complex behaviors is crucial.
Researchers found that in mouse models of neurodevelopmental disorders, ADHD is controlled by the host's genetic genes; while social behavior deficits are mediated by the gut microbiome.
Unexpectedly, when the researchers intervened in mice with a specific microorganism that promotes the production of biopterin family compounds in the intestine, it could improve the animals' social deficits, but they could not improve their ADHD behavior.

The corresponding author of the study, Dr.
Mauro Costa-Mattioli, Director of the Center for Memory and Brain Research at Baylor College of Medicine, said: “We are both host genes and carriers of microbial genes.
Although most research focuses on host genes, the gut microbiome It is also an important source of genetic information.
" In this study, the team provided a different perspective on neurological diseases and their treatments.
In this type of disease, human genes and microbial genes interact and cause the disease.
Researchers emphasize that effective treatment may need to target the brain and intestines at the same time to adequately resolve all symptoms.
In addition, the study also explored the possibility that complex diseases such as cancer, diabetes, viral infections or other neurological diseases involve the microbiome.
It is extremely difficult to study these complex interactions in the human body.
Therefore, the team studied a mouse model with neurodevelopmental disorders, which lacks two copies of the Cntnap2 gene (Cntnap2–/– mice).
They exhibit social deficits and hyperactive ADHD behaviors similar to those observed in patients with autism spectrum disorder (ASD).
In addition, compared with mice without modified genes, these genetically-deficient mice, like many people with autism, have changes in the composition of their intestinal flora.
Sean Dooling, the first author of the study and a PhD student in molecular and human genetics in Costa Mattioli’s laboratory, said: “We can distinguish between the microbiome and the impact of animal genetic mutations on behavioral changes.
This shows that in the study of health and disease, the gut microbiome It should not be ignored, it is also an important variable.
” Subsequently, the researchers further studied the mechanism of the influence of the gut microbiome on animal social deficits.
Based on their previous work, the researchers used Lactobacillus reuteri to treat mice.
Lactobacillus reuteri (L.
reuteri) occurs almost naturally in the intestines of all vertebrates and mammals.
In 2003, the Ministry of Health of my country has approved Lactobacillus reuteri as a microbial strain for human health care products, and this bacterium is an internationally recognized new type of probiotic lactic acid bacteria, which has high theoretical research and production application value.
The researchers found that Lactobacillus reuteri can also restore the social behavior of mice, but it cannot correct the overactive behavior of Cntnap2-/- mice.
However, when the researchers injected the metabolites of the tetrahydrobiopterin synthesis pathway into the socially disabled mice, the metabolites of Lactobacillus reuteri in the host intestine also increased; and after the metabolites were used to replace the bacteria, the mice The social deficiencies have also been improved.

In other words, the study provides at least two potential methods, namely, the use of intestinal bacteria or metabolites induced by bacteria to regulate brain function.
Can this research bring new breakthroughs in the treatment of neurological diseases? Although it is too early to draw conclusions, the researchers are hopeful about the transformative significance of their research.
The study emphasized the use of probiotics or bacteria to stimulate safe and effective treatments against the gut microbiome.
The researchers said that with a better understanding of these bacteria, it is expected that their power will be used more accurately and effectively to help treat complex human brain diseases and even more diseases.
Costa-Mattioli said: "Although scientific progress has brought the hope of genetic manipulation, there are still many difficulties in regulating human genes to treat diseases, but regulating our gut microbiome is an interesting non-invasive alternative.
I never thought that the microbes in the gut could regulate behavior and brain function.
Now it seems that microbial-based strategies may really be a feasible treatment for neurological dysfunction.
The idea is crazy but exciting.
In fact.
, Lactobacillus reuteri is currently undergoing clinical trials on children with autism in Italy, and we plan to start our own clinical trials soon.
" Link to the paper: https://doi.
org/10.
1016/j.
cell.
2021.
02.
009

---