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Bovine Leukemia Virus Ribozymes

 Last Update: 2021-02-14
 Source: Internet
 Author: User

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bovine leukemia virus

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Bovine leukemia virus (BLV) is a retrovirus structurally related to human T-cell leukemia virus-I and -II and simian T-cell leukemia virus. It infects principally B-lymphocytes (
1
), causing a persistent expansion of B-cells, termed persistent lymphocytosis, in approx 30% of infected cattle; about 5–10% of these animals eventually progress to leukemia or lymphoma (
2
). The disease is common in the United States, where economic losses as a result of the condemnation of carcasses with lymphoma cause an annual estimated loss of $44 million (
3
) and reduced milk and milkfat production in lactating cows with persistent lymphocytosis causes another $42 million annual loss (
4
,
5
). Loss of trade to countries which prohibit importation of BLV infected cattle is also a significant loss (
3
).

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