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All living organisms are constantly confronted by invading microbes. In mammals, host defense against microbial invasion requires specialized cellular and extracellular elements in blood and a complex signalling machinery that triggers their mobilization to extravascular sites of invasion in a highly regulated manner. This process is driven by microbe-specific signals, including highly conserved and chemically unique microbial (envelope) components, such as Gram-negative bacterial lipopolysaccharides (LPS) (
1
,
2
).