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Editor’s note iNature is China’s largest academic official account.
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us
.
iNature In nature, insects face the constant threat of many foreign virus infections, and their intestines are the main entry channel
.
However, insect intestines form a variety of physical and immune barriers to resist virus invasion
.
The successful establishment of infection in the intestine depends on the complex interaction between the virus and these barriers
.
On September 30, 2021, Professor Cheng Gong’s team from Tsinghua University School of Medicine published an invited review article titled "Interaction of Viruses with the Insect Intestine" in the Annual Review of Virology (IF=10.
43).
The review paper systematically summarized the insect vector The multiple mechanisms of animal and plant viruses interacting with the arboreal (mediator) intestines, and the prospects for the infection and transmission mechanism of arboreal and plant viruses in nature are put forward
.
Annual Review of Virology is an authoritative review journal widely recognized in the field of virology
.
Vector insects can transmit viruses and other pathogens to humans, plants or animals through feeding behaviors, causing corresponding human diseases, plant diseases and animal diseases, and seriously endangering the lives and health of humans, plants and animals
.
Human infectious diseases transmitted by vector insects (vector-borne infectious diseases) account for more than 17% of all infectious diseases, causing hundreds of millions of infections and millions of deaths each year, posing a serious threat to public health safety, such as the transmission of pathogens by mosquitoes in humans Zika fever, dengue fever, malaria and other important diseases
.
More than 80% of plant viruses are spread by insect vectors, causing up to 60 billion US dollars in agricultural production losses each year, posing a great threat to food security.
Among them, planthoppers alone can spread the virus and cause rice stripe disease and southern rice black-streak dwarf.
Severe agricultural diseases such as shrinking disease
.
In recent years, with the intensification of global climate change, the accelerated impact of human behavior on the environment, and the advancement of trade globalization, new outbreaks of vector-borne infectious diseases have increased suddenly, and the spread of epidemics has increased significantly.
This has become a major issue that all mankind in China and the world must face.
Biosafety challenges
.
In the process of vector-borne pathogen infection and disease production, vector transmission is an important part and the key to controlling vector-borne diseases and diseases
.
Insects obtain viruses by feeding or sucking blood, and the intestine is the organ of the insect's digestive system and is the first line of defense for viruses to invade insects
.
This review comprehensively and systematically summarizes the interaction between the "insect gut-arbovirus", expounds the different ways that viruses invade and infect the insect gut, as well as the defense mechanisms in insects and the strategies of virus immune escape.
Put forward important scientific issues that need to be solved urgently in this field, which will help to understand the survival strategy of arbovirus in nature and the mechanism of infection transmission (Figure 1)
.
Figure 1: The interaction mechanism of arboviruses in the intestinal tract of insects, Professor Cheng Gong, Tsinghua University School of Medicine, is the corresponding author of this article, Ma Enhao, a doctoral student at Tsinghua University School of Medicine, is the first author, and Zhu Yibin, assistant researcher, Tsinghua University School of Medicine, undergraduate Liu Ziwen, Professor Wei Taiyun from the Vector Virus Research Center of Fujian Agriculture and Forestry University and Professor Wang Penghua from the University of Connecticut School of Medicine are co-authors of this thesis
.
This paper was supported by the National Natural Science Foundation of China, the Ministry of Science and Technology, Tsinghua University-Peking University Life Joint Center, Shenzhen "Three Famous Projects" and other projects
.
Reference message: https://
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us
.
iNature In nature, insects face the constant threat of many foreign virus infections, and their intestines are the main entry channel
.
However, insect intestines form a variety of physical and immune barriers to resist virus invasion
.
The successful establishment of infection in the intestine depends on the complex interaction between the virus and these barriers
.
On September 30, 2021, Professor Cheng Gong’s team from Tsinghua University School of Medicine published an invited review article titled "Interaction of Viruses with the Insect Intestine" in the Annual Review of Virology (IF=10.
43).
The review paper systematically summarized the insect vector The multiple mechanisms of animal and plant viruses interacting with the arboreal (mediator) intestines, and the prospects for the infection and transmission mechanism of arboreal and plant viruses in nature are put forward
.
Annual Review of Virology is an authoritative review journal widely recognized in the field of virology
.
Vector insects can transmit viruses and other pathogens to humans, plants or animals through feeding behaviors, causing corresponding human diseases, plant diseases and animal diseases, and seriously endangering the lives and health of humans, plants and animals
.
Human infectious diseases transmitted by vector insects (vector-borne infectious diseases) account for more than 17% of all infectious diseases, causing hundreds of millions of infections and millions of deaths each year, posing a serious threat to public health safety, such as the transmission of pathogens by mosquitoes in humans Zika fever, dengue fever, malaria and other important diseases
.
More than 80% of plant viruses are spread by insect vectors, causing up to 60 billion US dollars in agricultural production losses each year, posing a great threat to food security.
Among them, planthoppers alone can spread the virus and cause rice stripe disease and southern rice black-streak dwarf.
Severe agricultural diseases such as shrinking disease
.
In recent years, with the intensification of global climate change, the accelerated impact of human behavior on the environment, and the advancement of trade globalization, new outbreaks of vector-borne infectious diseases have increased suddenly, and the spread of epidemics has increased significantly.
This has become a major issue that all mankind in China and the world must face.
Biosafety challenges
.
In the process of vector-borne pathogen infection and disease production, vector transmission is an important part and the key to controlling vector-borne diseases and diseases
.
Insects obtain viruses by feeding or sucking blood, and the intestine is the organ of the insect's digestive system and is the first line of defense for viruses to invade insects
.
This review comprehensively and systematically summarizes the interaction between the "insect gut-arbovirus", expounds the different ways that viruses invade and infect the insect gut, as well as the defense mechanisms in insects and the strategies of virus immune escape.
Put forward important scientific issues that need to be solved urgently in this field, which will help to understand the survival strategy of arbovirus in nature and the mechanism of infection transmission (Figure 1)
.
Figure 1: The interaction mechanism of arboviruses in the intestinal tract of insects, Professor Cheng Gong, Tsinghua University School of Medicine, is the corresponding author of this article, Ma Enhao, a doctoral student at Tsinghua University School of Medicine, is the first author, and Zhu Yibin, assistant researcher, Tsinghua University School of Medicine, undergraduate Liu Ziwen, Professor Wei Taiyun from the Vector Virus Research Center of Fujian Agriculture and Forestry University and Professor Wang Penghua from the University of Connecticut School of Medicine are co-authors of this thesis
.
This paper was supported by the National Natural Science Foundation of China, the Ministry of Science and Technology, Tsinghua University-Peking University Life Joint Center, Shenzhen "Three Famous Projects" and other projects
.
Reference message: https://
