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A study published by Nature today, Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein, shows that at the end of 2020, it will quickly become a new strain of the new coronavirus (SARS-CoV-2) in parts of South Africa.
The variant strain may have originated from the coast of the Eastern Cape after the end of the first pandemic.
The ability of this mutant strain to quickly replace other SARS-CoV-2 lineages in many places means that it has an advantage over other strains, and this advantage may be that it is more infectious.
The second round of SARS-CoV-2 pandemic in South Africa began around October 2020.
This round of the epidemic has spread particularly fast in parts of the Eastern Cape, Western Cape, and KwaZulu-Natal provinces, prompting People have stepped up genomic monitoring.
Tulio de Oliveira of the South African Genome Testing Network (NGS-SA) and the Research and Innovation Sequencing Platform (KRISP) of the University of KwaZulu-Natal in South Africa and colleagues analyzed the data collected in South Africa from March 5 to December 10, 2020.
The whole genome of 2882 SARS-CoV-2 cases, and a new SARS-CoV-2 variant strain (named 501Y.
V2/B.
1.
351) was discovered.
Their data shows that this new variant appeared in Nelson Mandela Bay around August 2020, and became the Eastern Cape, Western Cape and KwaZulu-Natal at the end of 2020.
The main popular pedigree.
The 501Y.
V2 variant has 8 mutations in the spike protein-the spike protein can mediate the virus into the cell.
Among them, the N501Y mutation also exists in a variant strain (B.
1.
1.
7) found in the UK, and is related to the tight binding of the human ACE2 receptor.
Studies have shown that another mutation E484K is related to resistance to neutralizing antibodies.
The distribution and spread of the 501Y.
V2 variant strain and the results of genome analysis show that this variant strain may be more infectious than other SARS-CoV-2 lineages.
However, the author believes that the importance and impact of these mutations have not yet been fully clarified, and further research is needed.
501Y.
V2 The variation of the spike site.
Picture from Tulio de Oliveira et al.
©Nature Nature | doi: 10.
1038/s41586-021-03402-9
The variant strain may have originated from the coast of the Eastern Cape after the end of the first pandemic.
The ability of this mutant strain to quickly replace other SARS-CoV-2 lineages in many places means that it has an advantage over other strains, and this advantage may be that it is more infectious.
The second round of SARS-CoV-2 pandemic in South Africa began around October 2020.
This round of the epidemic has spread particularly fast in parts of the Eastern Cape, Western Cape, and KwaZulu-Natal provinces, prompting People have stepped up genomic monitoring.
Tulio de Oliveira of the South African Genome Testing Network (NGS-SA) and the Research and Innovation Sequencing Platform (KRISP) of the University of KwaZulu-Natal in South Africa and colleagues analyzed the data collected in South Africa from March 5 to December 10, 2020.
The whole genome of 2882 SARS-CoV-2 cases, and a new SARS-CoV-2 variant strain (named 501Y.
V2/B.
1.
351) was discovered.
Their data shows that this new variant appeared in Nelson Mandela Bay around August 2020, and became the Eastern Cape, Western Cape and KwaZulu-Natal at the end of 2020.
The main popular pedigree.
The 501Y.
V2 variant has 8 mutations in the spike protein-the spike protein can mediate the virus into the cell.
Among them, the N501Y mutation also exists in a variant strain (B.
1.
1.
7) found in the UK, and is related to the tight binding of the human ACE2 receptor.
Studies have shown that another mutation E484K is related to resistance to neutralizing antibodies.
The distribution and spread of the 501Y.
V2 variant strain and the results of genome analysis show that this variant strain may be more infectious than other SARS-CoV-2 lineages.
However, the author believes that the importance and impact of these mutations have not yet been fully clarified, and further research is needed.
501Y.
V2 The variation of the spike site.
Picture from Tulio de Oliveira et al.
©Nature Nature | doi: 10.
1038/s41586-021-03402-9
