Adv Sci: Reveals the important role of TGF beta 2 in esophageal cancer metastasis and targeted intervention strategies.

Tumor metastasis is one of the top ten characteristics of cancer, and more than 90% of cancer deaths are closely related to tumor metastasis. More and more studies
point out that the tumor microenvironment, especially various cytokines, also plays an important role in the malignant development of tumors.
therefore, the use of the latest progress in international and domestic medical biology, combined with the latest science and technology in various disciplines, the development of effective, small toxic side effects to prevent and treat tumor metastasis biologics, is one of the key problems to overcome tumors.
recently, Professor He Qingyu, Li Bin Researcher, associate researcher of Xu Wei, Key Laboratory of the Ministry of Oncology Molecular Biology of Jinan University, published direct targeting of CREB1 with imperatorin inhibits TGF beta 2-ERK signaling to suppress healthe in Advanced Science online The al cancer metastasis research paper, which combines public databases and clinical pathology data to analyze the expression of TGF beta 2 in clinical samples, for the first time pointed out that TGF beta 2 was significantly highly expressed in esophageal cancer tumor tissue and was significantly negatively correlated with patient survival.
innovative use of high-throughput drug screening platforms, screening findings that significantly inhibit esophageal cancer attack and TGF beta 2 signaling pathways of the small molecule drug euprene.
this study combined with in vitro models of a variety of cells, it is suggested that opiate effectively inhibits the invasion and metastasis of esophageal cancer.
in order to explore the molecular mechanism of pre-opus inhibition of invasive metastasis, the team used quantitative proteomics to compare the protein expression spectrum between esophagus cancer cells after apulin treatment and control groups, and to conduct bioinformatics analysis based on proteins expressed by significant differences to find relevant downstream pathways.
data suggest that euprecin may function by affecting the TGF beta 2-ERK pathway.
then, after a series of molecular dynamics, molecular biology, clinical pathology analysis and other experiments, the verification found that eupresin through direct binding with CREB1 protein, inhibit creB1 phosphorylation and its transcription regulation of TGF beta 2, and thus reduce the expression of TGF beta 2, block erK signaling pathway, play a role in esophageal cancer attack metastasis inhibition.
the research team from the biological function, clinical significance, molecular regulation mechanism of three aspects of the in-depth study of the inhibition of euthanus on esophageal cancer attack metastasis, this research results for esophageal cancer non-invasive diagnosis of prognosis molecular markers and drug selection to provide new clues.
, Vice-Researcher xu Wei of the University of Science and graduate student Huang Zhihao, co-first author of this paper, Professor He Qingyu of the University of Jinan Academy of Sciences, Li Bin Researcher, and Xu Wei Associate Researcher, co-author of this paper.
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