Adv. Sci., Professor Yongqiang Li’s group, Shandong University: Nanophysical Antimicrobial Strategies: Fighting Bacterial Infections by Rational Deployment of Nanomaterials and Physical Stimuli

Innovation: Nanophysical Antimicrobial Strategies (NPAS) collided by the "beautiful and incredible" encounter between nanomaterials and physical stimuli have become an important research area
.

This review systematically introduces the applications and future challenges of NPAS in combating bacterial infections based on physical stimulation modalities (including mechanical, optical, magnetic, acoustic, and electrical signals, etc.
), with a view to providing new insights and ideas for combating bacterial drug resistance
.

Key words: bacterial infection; drug resistance; nanomaterials; physical stimuli Long-term abuse of antibiotics forces bacteria to mutate and evolve continuously, resulting in the increasing resistance of bacteria to antibiotics.
Spreading at an alarming rate, bacterial infections have become a global challenge
.

Faced with the serious threat of bacterial resistance, the development of new antibiotics is lagging far behind, and there is an urgent need to develop new antibacterial strategies and technologies
.

Physical stimuli-based antibacterial approaches are considered an effective way to combat bacterial resistance, which can act on multiple bacterial targets and achieve efficacy against pathogenic bacteria by mechanical stretching, interfering, and disrupting bacterial metabolism/respiration.
kill without causing resistance
.

In addition, with the rapid development of nanotechnology, the unique physical and chemical properties of nanomaterials have greatly expanded the application scope of physical antibacterials, and also provided a bridge for combining and utilizing a variety of physical antibacterial methods
.

Benefiting from the unique advantages of physical antibacterial methods and nanomaterials, nanophysical antibacterial strategies (NPAS) to combat bacterial infections through rational deployment of nanomaterials and physical stimuli have received rapid development and extensive attention
.

In order to summarize this rapidly developing field in time, the research group of Professor Li Yongqiang from the School of Physics, Shandong University systematically introduced the application of NPAS in combating bacterial infections according to different physical stimulation modes (including mechanical, optical, magnetic, acoustic and electrical signals, etc.
).
, and detailed the design concepts and antibacterial mechanisms of different physical stimulation modalities, in order to provide a paradigm and reference for researchers
.

At the same time, the paper also introduces and discusses the challenges faced by NPAS in the treatment of clinical bacterial infections, and looks forward and thinks about the future application of NPAS, in order to promote the further development of this field
.

WILEY paper information: Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial InfectionsBingqing Jia, Xuancheng Du, Weijie Wang, Yuanyuan Qu, Xiangdong Liu, Mingwen Zhao, Weifeng Li*, Yong-Qiang Li*Advanced ScienceDOI: 10.
1002 /advs.
202105252Click "Read the original text" in the lower left corner to view the original text of the paper
.

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