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"ACS AMI" from the research group of Professor Wang Jianlong of Northwest A&F University: Peroxidation based on dextran coating...

 Last Update: 2021-07-20
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Wound infections caused by bacterial biofilms have always threatened human health and can cause high mortality
.

In recent years, the application of nano antibacterial materials in wound healing has become the focus of research.

Recently, the research group of Professor Wang Jianlong of Northwest A&F University published an article entitled " Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment " in the journal " ACS Applied Materials & Interfaces " ( DOI: 10.

1021 /acsami.

Scheme 1.

(a) Schematic diagram of the anti-biofilm performance of DCPNA s through acid-induced release of ROS ; (b) Schematic diagram of the in vivo anti-biofilm study of DCPNAs using mice with wound skin as an infected wound model

figure (A) DCPNA S synthesis scheme; (B ) in a different OH ^- and a Cu ²molar ratio combining DCPNAs photos

: (A) 0:.

1 ; (B).
1: 2 ; (C).
1:.

Figure 2.
(a) Detect the catalytic performance of DCPNAs at different pH values by TMB color development ; (b) Use DCFH to detect the ROS generation of DCPNAs at different pH values , the illustration shows the percentage of ROS generation ; use different under different pH values concentration DCPNA S process (c) Staphylococcus aureus, and (D) the bacteria Salmonella density ; (E) at different pH at values through with and without DCPNA S treated S.
aureus and Salmonella bacterial colonies grown image; ( f) At different pH valuesSEM images of Staphylococcus aureus and Salmonella treated with and without DCPNAs

Figure 3.
Biofilm biomass of (a) Staphylococcus aureus and (b) Salmonella under different pH values with and without DCPNA s treatment (n = 3, * P <0.
05) ; (c) at pH 7.
4 ( I-1 / II-1 ), pH 6.
5 ( I-2 / II-2 ) and pH 5.
6 ( I-3 / II -3 ) without DCPNA s treatment ( I -1-I -3 ) and after DCPNA Crystal violet staining of biofilms of Staphylococcus aureus and Salmonella treated with s ( II -1-II -3 ) ; ( d ) 3D CLSM of biofilms inhibited by DCPNAs at different pH values Image, the size of the captured image area is 1270 μm × 1270 μm ; (e) The catalytic performance of DCPNA s in the intact biofilm (the blank is the untreated biofilm) .
(f) The effect of DCPNA s on the destruction of biofilms based on MTT determination

Figure 4.

Application test results of DCPNAs in the treatment of bacterial infection wounds: (a) Schematic diagram of DCPNAs treating wounds; (b) Changes of wounds in each group; (c) Antibacterial effects of DCPNAs on wound surface bacteria; (d) ) Histogram of changes in wound area of each group over time (* P <0.

Figure 5.
H&E stained sections of the main organs of mice in each group at 9 days of treatment

Li Min, a graduate of the School of Food Science and Engineering, Northwest A&F University, is the first author of the paper.

The co-corresponding authors are Professor Wang Jianlong and Associate Professor Zhang Wentao

About the Author

Wang Jianlong, male, born in 1979, Ph.

D.
, professor, doctoral supervisor, won the special government allowance of the State Council, was selected as a leader in young science and technology innovation in the Shaanxi Province Innovative Talent Promotion Plan, won the Shaanxi Province Outstanding Youth Fund, and was selected as the New Century Excellent Talent of the Ministry of Education , The young science and technology star of Shaanxi Province, was selected into the " Top 1% Highly Cited Chinese Authors" list of the

Zhang Wentao, male, Ph.

Research group website:
https://