A team of scientists discovered the new metabolic ability of gut bacteria and explained the source of hydrogen sulfide

An international team of scientists led by microbiologist Professor Alexander Loy of the University of Vienna and Professor David Schleheck of the University of Konstanz discovered the new metabolic capacity of gut bacteria. The researchers analyzed for the first time how the microbes in the gut process the plant-based sulfur sugar sulfoquinolose. Thioquinolose is a sulfonic acid derivative of glucose and can be found in all green vegetables such as spinach and lettuce. Their research found that specialized bacteria cooperate with sulfo sugars to produce hydrogen sulfide. This gas is known for the smell of rotten eggs and has different effects on human health: at low concentrations, it has an anti-inflammatory effect, and the increase in hydrogen sulfide content in the intestines is related to cancer and other diseases. The research has been published in this issue of "ISME Journal". With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract. There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species. Therefore, the gut microbiome plays an important role in determining how nutrition affects our health. "However, so far, the metabolic capacity of many microorganisms in the microbiome is still unknown. This means that we don't know what substances they feed on and how they process these substances," the lead author of the study, Vienna Explains Buck Hanson, a microbiologist at the University's Center for Microbiology and Environmental Systems Science (CMESS). "By exploring the microbial metabolism of the sulfoquinovose in the gut for the first time, we have learned a little bit about this black box," he added. This research has generated the necessary knowledge to target the interaction between nutrition and the microbiome in future treatments. Sulfosugar is a sulfonic acid derivative of glucose, mainly found in green vegetables such as spinach, lettuce and algae, and is a chemical building block. According to previous studies by the research team led by microbiologist David Schleheck at the University of Konstanz, other microorganisms can in principle use sulfonic acid as a nutrient. In their current study, researchers from the University of Konstanz and the University of Vienna used the analysis of fecal samples to determine how these processes take place in the human intestine. "We have now been able to show that, unlike glucose, which feeds a large number of microbes in the gut, thioquinolulose stimulates the growth of very specific key microbes in the gut microbiome," said David Schleheck. These key organisms include bacteria of the Eubacterium rectale species, which is one of the ten most common gut microbes in healthy people. "E. rectal bacteria fermentes thioquinolose through a metabolic pathway that we have only recently interpreted to produce a sulfur compound called dihydroxypropane sulfonate or DHPS for short. This sulfur compound is in turn other intestinal bacteria such as Bilophila wadsworthia. The microbiologist explained: "Bilophila wadsworthia will eventually produce hydrogen sulfide from DHPS through a metabolic pathway, which was discovered only recently. Hydrogen sulfide is produced by our own body cells and specialized microorganisms in the intestine, and has many effects on our body. According to current knowledge, it can have a positive effect on intestinal health, but it also has a negative effect. 　　A decisive factor is the dose: at low doses, hydrogen sulfide can have an anti-inflammatory effect on the intestinal mucosa. On the other hand, the increase of hydrogen sulfide produced by intestinal microbes is related to chronic inflammatory diseases and cancer. So far, it is mainly due to diets rich in meat or fat that increase the content of sulfate and taurine in the intestines, which are known to be sources of microbial hydrogen sulfide. Therefore, it is surprising to find that thioquinolose derived from green foods such as spinach and algae also contributes to the production of gas in the intestinal tract. 　　"We have shown that we can use sulfoquinolose to promote the growth of very special intestinal bacteria, which are an important part of our intestinal microbiome. We now know that these bacteria will produce contradictory sulfides from them. Hydrogen. " Loy concluded. 　　Further research by scientists from Konstanz and Vienna will now clarify whether and how the intake of plant-based sulfur sugars has a health-promoting effect. "Thioquinolose may also be classified as a so-called probiotic," Schleheck added.      Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com. The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself.      Copyright Notice    1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author. 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and clearly indicate the source and author. Media or individuals who do not want to be reprinted can contact us for infringement information that can provide sufficient evidence , Bio149 will be deleted within 12 hours after confirmation. 3. Users are welcome to post original articles to 86371366@qq. com, and publish them to the homepage after review. The copyright and liability belong to the sender.

　　An international team of scientists led by microbiologist Professor Alexander Loy of the University of Vienna and Professor David Schleheck of the University of Konstanz discovered the new metabolic capacity of gut bacteria.
The researchers analyzed for the first time how the microbes in the gut process the plant-based sulfur sugar sulfoquinolose.
　　Thioquinolose is a sulfonic acid derivative of glucose and can be found in all green vegetables such as spinach and lettuce.
Their research found that specialized bacteria cooperate with sulfo sugars to produce hydrogen sulfide.
This gas is known for the smell of rotten eggs and has different effects on human health: at low concentrations, it has an anti-inflammatory effect, and the increase in hydrogen sulfide content in the intestines is related to cancer and other diseases.
　　The research has been published in this issue of "ISME Journal".
　　With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract.
There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species.
Therefore, the gut microbiome plays an important role in determining how nutrition affects our health.
　　"However, so far, the metabolic capacity of many microorganisms in the microbiome is still unknown.
This means that we don't know what substances they feed on and how they process these substances," the lead author of the study, Vienna Explains Buck Hanson, a microbiologist at the University's Center for Microbiology and Environmental Systems Science (CMESS).
"By exploring the microbial metabolism of the sulfoquinovose in the gut for the first time, we have learned a little bit about this black box," he added.
This research has generated the necessary knowledge to target the interaction between nutrition and the microbiome in future treatments.
　　Sulfosugar is a sulfonic acid derivative of glucose, mainly found in green vegetables such as spinach, lettuce and algae, and is a chemical building block.
According to previous studies by the research team led by microbiologist David Schleheck at the University of Konstanz, other microorganisms can in principle use sulfonic acid as a nutrient.
　　In their current study, researchers from the University of Konstanz and the University of Vienna used the analysis of fecal samples to determine how these processes take place in the human intestine.
　　"We have now been able to show that, unlike glucose, which feeds a large number of microbes in the gut, thioquinolulose stimulates the growth of very specific key microbes in the gut microbiome," said David Schleheck.
These key organisms include bacteria of the Eubacterium rectale species, which is one of the ten most common gut microbes in healthy people.
　　"E.
rectal bacteria fermentes thioquinolose through a metabolic pathway that we have only recently interpreted to produce a sulfur compound called dihydroxypropane sulfonate or DHPS for short.
This sulfur compound is in turn other intestinal bacteria such as Bilophila wadsworthia.
The microbiologist explained: "Bilophila wadsworthia will eventually produce hydrogen sulfide from DHPS through a metabolic pathway, which was discovered only recently.
　　Hydrogen sulfide is produced by our own body cells and specialized microorganisms in the intestine, and has many effects on our body.
According to current knowledge, it can have a positive effect on intestinal health, but it also has a negative effect.
　　A decisive factor is the dose: at low doses, hydrogen sulfide can have an anti-inflammatory effect on the intestinal mucosa.
On the other hand, the increase of hydrogen sulfide produced by intestinal microbes is related to chronic inflammatory diseases and cancer.
So far, it is mainly due to diets rich in meat or fat that increase the content of sulfate and taurine in the intestines, which are known to be sources of microbial hydrogen sulfide.
Therefore, it is surprising to find that thioquinolose derived from green foods such as spinach and algae also contributes to the production of gas in the intestinal tract.
　　"We have shown that we can use sulfoquinolose to promote the growth of very special intestinal bacteria, which are an important part of our intestinal microbiome.
We now know that these bacteria will produce contradictory sulfides from them.
Hydrogen.
" Loy concluded.
　　Further research by scientists from Konstanz and Vienna will now clarify whether and how the intake of plant-based sulfur sugars has a health-promoting effect.
"Thioquinolose may also be classified as a so-called probiotic," Schleheck added.

---

　　An international team of scientists led by microbiologist Professor Alexander Loy of the University of Vienna and Professor David Schleheck of the University of Konstanz discovered the new metabolic capacity of gut bacteria.
The researchers analyzed for the first time how the microbes in the gut process the plant-based sulfur sugar sulfoquinolose.
　　Thioquinolose is a sulfonic acid derivative of glucose and can be found in all green vegetables such as spinach and lettuce.
Their research found that specialized bacteria cooperate with sulfo sugars to produce hydrogen sulfide.
This gas is known for the smell of rotten eggs and has different effects on human health: at low concentrations, it has an anti-inflammatory effect, and the increase in hydrogen sulfide content in the intestines is related to cancer and other diseases.
　　The research has been published in this issue of "ISME Journal".
　　With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract.
There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species.
Therefore, the gut microbiome plays an important role in determining how nutrition affects our health.
　　"However, so far, the metabolic capacity of many microorganisms in the microbiome is still unknown.
This means that we don't know what substances they feed on and how they process these substances," the lead author of the study, Vienna Explains Buck Hanson, a microbiologist at the University's Center for Microbiology and Environmental Systems Science (CMESS).
"By exploring the microbial metabolism of the sulfoquinovose in the gut for the first time, we have learned a little bit about this black box," he added.
This research has generated the necessary knowledge to target the interaction between nutrition and the microbiome in future treatments.
　　Sulfosugar is a sulfonic acid derivative of glucose, mainly found in green vegetables such as spinach, lettuce and algae, and is a chemical building block.
According to previous studies by the research team led by microbiologist David Schleheck at the University of Konstanz, other microorganisms can in principle use sulfonic acid as a nutrient.
　　In their current study, researchers from the University of Konstanz and the University of Vienna used the analysis of fecal samples to determine how these processes take place in the human intestine.
　　"We have now been able to show that, unlike glucose, which feeds a large number of microbes in the gut, thioquinolulose stimulates the growth of very specific key microbes in the gut microbiome," said David Schleheck.
These key organisms include bacteria of the Eubacterium rectale species, which is one of the ten most common gut microbes in healthy people.
　　"E.
rectal bacteria fermentes thioquinolose through a metabolic pathway that we have only recently interpreted to produce a sulfur compound called dihydroxypropane sulfonate or DHPS for short.
This sulfur compound is in turn other intestinal bacteria such as Bilophila wadsworthia.
The microbiologist explained: "Bilophila wadsworthia will eventually produce hydrogen sulfide from DHPS through a metabolic pathway, which was discovered only recently.
　　Hydrogen sulfide is produced by our own body cells and specialized microorganisms in the intestine, and has many effects on our body.
According to current knowledge, it can have a positive effect on intestinal health, but it also has a negative effect.
　　A decisive factor is the dose: at low doses, hydrogen sulfide can have an anti-inflammatory effect on the intestinal mucosa.
On the other hand, the increase of hydrogen sulfide produced by intestinal microbes is related to chronic inflammatory diseases and cancer.
So far, it is mainly due to diets rich in meat or fat that increase the content of sulfate and taurine in the intestines, which are known to be sources of microbial hydrogen sulfide.
Therefore, it is surprising to find that thioquinolose derived from green foods such as spinach and algae also contributes to the production of gas in the intestinal tract.
　　"We have shown that we can use sulfoquinolose to promote the growth of very special intestinal bacteria, which are an important part of our intestinal microbiome.
We now know that these bacteria will produce contradictory sulfides from them.
Hydrogen.
" Loy concluded.
　　Further research by scientists from Konstanz and Vienna will now clarify whether and how the intake of plant-based sulfur sugars has a health-promoting effect.
"Thioquinolose may also be classified as a so-called probiotic," Schleheck added.

---

　　An international team of scientists led by microbiologist Professor Alexander Loy of the University of Vienna and Professor David Schleheck of the University of Konstanz discovered the new metabolic capacity of gut bacteria.
The researchers analyzed for the first time how the microbes in the gut process the plant-based sulfur sugar sulfoquinolose.
　　Thioquinolose is a sulfonic acid derivative of glucose and can be found in all green vegetables such as spinach and lettuce.
Their research found that specialized bacteria cooperate with sulfo sugars to produce hydrogen sulfide.
This gas is known for the smell of rotten eggs and has different effects on human health: at low concentrations, it has an anti-inflammatory effect, and the increase in hydrogen sulfide content in the intestines is related to cancer and other diseases.
　　The research has been published in this issue of "ISME Journal".
　　With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract.
There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species.
Therefore, the gut microbiome plays an important role in determining how nutrition affects our health.
　　"However, so far, the metabolic capacity of many microorganisms in the microbiome is still unknown.
This means that we don't know what substances they feed on and how they process these substances," the lead author of the study, Vienna Explains Buck Hanson, a microbiologist at the University's Center for Microbiology and Environmental Systems Science (CMESS).
"By exploring the microbial metabolism of the sulfoquinovose in the gut for the first time, we have learned a little bit about this black box," he added.
This research has generated the necessary knowledge to target the interaction between nutrition and the microbiome in future treatments.
　　Sulfosugar is a sulfonic acid derivative of glucose, mainly found in green vegetables such as spinach, lettuce and algae, and is a chemical building block.
According to previous studies by the research team led by microbiologist David Schleheck at the University of Konstanz, other microorganisms can in principle use sulfonic acid as a nutrient.
　　In their current study, researchers from the University of Konstanz and the University of Vienna used the analysis of fecal samples to determine how these processes take place in the human intestine.
　　"We have now been able to show that, unlike glucose, which feeds a large number of microbes in the gut, thioquinolulose stimulates the growth of very specific key microbes in the gut microbiome," said David Schleheck.
These key organisms include bacteria of the Eubacterium rectale species, which is one of the ten most common gut microbes in healthy people.
　　"E.
rectal bacteria fermentes thioquinolose through a metabolic pathway that we have only recently interpreted to produce a sulfur compound called dihydroxypropane sulfonate or DHPS for short.
This sulfur compound is in turn other intestinal bacteria such as Bilophila wadsworthia.
The microbiologist explained: "Bilophila wadsworthia will eventually produce hydrogen sulfide from DHPS through a metabolic pathway, which was discovered only recently.
　　Hydrogen sulfide is produced by our own body cells and specialized microorganisms in the intestine, and has many effects on our body.
According to current knowledge, it can have a positive effect on intestinal health, but it also has a negative effect.
　　A decisive factor is the dose: at low doses, hydrogen sulfide can have an anti-inflammatory effect on the intestinal mucosa.
On the other hand, the increase of hydrogen sulfide produced by intestinal microbes is related to chronic inflammatory diseases and cancer.
So far, it is mainly due to diets rich in meat or fat that increase the content of sulfate and taurine in the intestines, which are known to be sources of microbial hydrogen sulfide.
Therefore, it is surprising to find that thioquinolose derived from green foods such as spinach and algae also contributes to the production of gas in the intestinal tract.
　　"We have shown that we can use sulfoquinolose to promote the growth of very special intestinal bacteria, which are an important part of our intestinal microbiome.
We now know that these bacteria will produce contradictory sulfides from them.
Hydrogen.
" Loy concluded.
　　Further research by scientists from Konstanz and Vienna will now clarify whether and how the intake of plant-based sulfur sugars has a health-promoting effect.
"Thioquinolose may also be classified as a so-called probiotic," Schleheck added.

---