A new coronavirus strain was discovered in Europe, far more virulent than India's "triple mutant"

19 mutations, 2 mutation points that can be immune to escape.
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Author | Jiang Feixiong Nina As India's epidemic shocked the world, India's triple mutant strains became famous, making people feel that the Gu King has been born.

However, B.
1.
620, a 19-fold mutant strain containing many key mutations, turned out to be followed up by two top journals, Nature and Science, which made people think that this mutant strain competition may not yet exist.
In the white-hot stage.
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the title of the Nature report: How does a worrisome new crown mutant strain spread quietly with the 19-fold mutation, and what characteristics does it have? The reason why Nature said that this mutant strain was spreading "quietly" is because it was a bit late when it was discovered that it "has stunts".
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B.
1.
620 appeared in Europe as early as February this year, but until April, Lithuanian researchers sequenced it, which revealed the identity of its 19 mutations.

The reason why Lithuanian researchers sequenced it was related to Lithuania’s rapidly rising infection rate.
American researchers speculated that B.
1.
620 was the culprit of the local epidemic.

So, how powerful are these 19 mutations.
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Look at the picture below.

This is the sequencing result in the preprint released by Lithuanian researchers.
The first line is the mutation point of B.
1.
620.
All the colored grids in the figure indicate that the virus has this mutation point, and the red grid means that only B.
1.
620 has this mutation point.
Mutations.

The last line of the King of Drug Hegemony table is the recent eye-catching variant of India, and the first line is B.
1.
620, which is full of the mutation table.

The "star" mutant strains P.
1 and B.
1.
351 can also be seen in it, and the notorious mutation point E484K-which can be immune to escape-is listed impressively.

In addition, the mutation point S477N also has the ability to escape immunity.

In other words, B.
1.
620 has at least two immune escape sites, while the previous P.
1, B.
1.
617, and B.
1.
351 that swept South America and Europe and dominated India have only one immune escape mutation.
Site.

In addition to the two mutation sites with immune escape ability, in the preprint, the researchers analyzed that the comprehensive mutation of the N-Terminal Domain (NTD) of B.
1.
620 makes it resistant to neutralizing antibodies.

At the same time, the P681H possessed by B.
1.
620 can increase the spread, and the highly transmissible mutant strain B.
1.
1.
7, which once caused the UK to make trouble, also has this mutation site.

The study pointed out that in this 19-fold mutant strain, there are quite a lot of mutation points whose functions and properties cannot be clarified.
Therefore, it is not that it has only three mutation points with dangerous characteristics, but some remaining mutations.
It is temporarily beyond the scope of human knowledge.
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It is still unclear whether there will be any "surprise" and "scare" in this full row of mutations.

Science directly pointed out in its report on this variant, "it is a typical variant that needs to raise all red flags.
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How about the spread of B.
1.
620? According to the currently available evidence, researchers tend to believe that the virus originated in the Central African Republic and Cameroon and spread to Europe via flights.

However, due to the lack of detection capabilities in Africa, the spread and coverage of the virus in Africa are temporarily unknown.

Europe was previously struggling to deal with the epidemic caused by mutant strains such as P.
1, B.
1.
617, B.
1.
351, and at the same time, due to the extremely fast mutation rate of the new coronavirus, there are so many mutant strains, which makes Europe unable to screen out this strain in time.
A new mutation with a huge threat.

The study conservatively estimates that B.
1.
620 is still mainly spread by travel in Europe, and it cannot be said that it has entered a state of community transmission for the time being. But it cannot be denied that it has blossomed in many places in Europe.
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The picture below shows the distribution of patients with B.
1.
620 detected and reported by the researchers.
The chromatogram icon represents their travel history, and the tree shape at the top The figure shows the virus lineage, and the red circles represent the earliest patients with travel history.

It can be seen from the figure that some of the B.
1.
620 variants detected in Europe have bred for at least two generations.
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The distribution and pedigree of B.
1.
620 in Europe It is speculated that B.
1.
620 may land in Europe as early as February.
The data obtained by April is still in a fragmented state as shown in the figure.

Now we can no longer take it lightly as "the absence of rapid spread means that it is not powerful".
B.
1.
617, which is turning South Asia into hell, does not immediately occupy the main "market share" at the beginning, and B.
1.
620 is likely to have It has a stronger immune escape ability than B.
1.
617.
It is still unknown how effective the vaccine can be.
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B.
1.
617 is already approaching us gradually.
Facing B.
1.
620, which carries more risk factors, "Be vigilant.
"Tighten the fence" is still a must. eu/en/covid-19/variants-concern Source: Medical editor in charge: Li Shanshan Proofreading: Zang Hengjia Plate-making: Shu Qian's wonderful review of the past The epidemic burned to the door, five experts infected with the new crown variant strain in Vietnam The new crown epidemic has killed 10 million people ? ! The Economist: The global death toll is severely underestimated.
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The possibility of large-scale spread of the epidemic in Anhui Province is basically ruled out